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Biomedical subjects

J M Patel

Publications and source records attributed to J M Patel.

At least 73 records · Page 4Linked to original sources

Ultrasonic prediction of fetal macrosomia in diabetic patients.

Traumatic morbidity in the newborn of a diabetic mother occurs in 3 to 9% of vaginal deliveries in diabetic pregnancies. Prediction of diabetic macrosomia by ultrasound measurement of chest diameter and biparietal diameter is evaluated in this study. A macrosomia index was calculated for 70 diabetic pregnancies by subtracting the biparietal diameter from the chest diameter (chest - biparietal diameter). Twenty-three macrosomic infants (weight greater than 4000 g) were delivered. In this study 20/23 (87%) of the infants weighing greater than 4000 g had a chest - biparietal diameter of 1.4 cm or greater. There were 4 cases of shoulder dystocia in 15 patients delivered vaginally. In this study, cesarean section for all fetuses with a chest - biparietal diameter of 1.4 cm or greater would reduce the incidence of traumatic morbidity from 27% to 9%.

Body Weight↗

Hepatic drug hydroxylation and lipid peroxidation in riboflavin-deficient rats.

The effect of riboflavin deficiency and phenobarbital pretreatment on drug hydroxylation and lipid peroxidation was investigated. A significant decrease in aniline and acetanilide hydroxylation as well as NADPH-linked and ascorbate-induced lipid peroxidation was observed during 4- and 7-week riboflavin deficiency in both adult male and adult female rats. The drug-hydroxylation and lipid-peroxidation activities were further lowered with the increase in riboflavin deficiency. The phenobarbital pretreatment induced aniline and acetanilide hydroxylase activity even in riboflavin-deficient animals. Drug hydroxylation inhibits lipid peroxidation in both deficient and normal rats. The administration of riboflavin was followed by a significant increase in drug hydroxylation and lipid peroxidation.

Acetanilides↗