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Biomedical subjects

J M O'Brien

Publications and source records attributed to J M O'Brien.

119 records · Page 7Linked to original sources
PubMedDate not supplied

The genetics of retinoblastoma and current diagnostic testing.

We review the genetics of retinoblastoma and the most recent molecular detection methods. Retinoblastoma, the most common intraocular tumor in children, occurs in either a heritable or non-heritable form. The heritable form, which is highly penetrant and predisposes individuals to a considerably greater second tumor risk, can be distinguished most definitively through the use of genetic testing. Genetic testing for individuals and families suspected of carrying the heritable mutations can help ensure that more comprehensive treatment plans and accurate genetic counseling for affected individuals and their families are provided.

DNA, Neoplasm↗
PubMedDate not supplied

Combined hamartoma of the retina and retinal pigment epithelium as the presenting sign of neurofibromatosis-1.

The authors report a case of combined harmartoma of the retina and retinal pigment epithelium in a 6-year-old child as the presenting sign of neurofibromatosis-1. The patient was followed closely for three years but received no treatment. Observation over these years revealed no significant change in the patient's visual acuity. A referral to the University of California San Francisco (UCSF) Neurofibromatosis Clinic resulted in a diagnosis of neurofibromatosis (NF)-1, and she continues to be observed for further systemic manifestations of this disease. Combined hamartoma of the retina and retinal pigment epithelimicrom, a rare and benign tumor, can be easily mistaken for malignant processes such as retinoblastoma or choroidal melanoma. Ophthalmologists should also be aware of the association with neurofibromatosis and consider this diagnosis when such retinal findings are observed in a child.

Child↗
PubMedDate not supplied

Comparison of tape products on skin integrity.

A two-group, nonconcurrent design was used in this comparative study to assess the incidence of skin breakdown accompanying Durapore silk tape and Medipore soft cloth tape (both manufactured by 3M Health Care). A significantly higher number of skin tears were found with silk tape use (mean 2 = 7.69, p < 0.01). This type of skin damage caused patient discomfort and incurred additional treatment costs. Soft cloth tape is recommended to decrease skin tears in surgical patients.

Adhesives↗