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Biomedical subjects

J M Noe

Publications and source records attributed to J M Noe.

At least 37 records · Page 2Linked to original sources
PubMed1981

Healing of port-wine stains after argon laser therapy.

Studies have shown port-wine stains (PWSs) probably represent an aneurysmal dilation and ectasia of the cutaneous vascular plexus. The abnormal vessels are largely included within a 0.6-mm subepidermal zone, which is within the argon laser destruction range. Twenty-eight patients with PWSs underwent biopsies prior to argon laser treatment and repeated biopsies 4 1/2 months later. Those lesions (23) that contained large ectatic blood-filled vessels responded well to argon laser therapy in contrast to those (five) in which the vessels were relatively small and erythrocyte free. A similar histologic pattern was seen in the repeated biopsy specimens of both groups: the mean vessel area, the fraction of dermis occupied by vessels, vascular erythrocyte content, and vessel wall thickness sharply decreased, while the number of vessels tripled. Since lesion color strongly correlates with and probably is largely determined by erythrocyte content, the reason for the PWS lightening, despite increased vessel number, is the relative lack of erythrocytes in the newly formed vessels.

Adolescent↗
PubMed1980

Where should the knot be placed?

When suturing a wound the surgeon should consider where to locate the knot. Suture placement and removal, patient comfort, wound healing, and cosmetic result can be facilitated by proper knot placement.

Humans↗
PubMed1980

Acral lentiginous melanoma.

Acral lentiginous melanoma occurs on the hands and feet, with a particular predilection for the fingers, toes, subungual areas, and heels. It is characterized by a lateral growth phase followed by a vertical growth phase. Despite the small number of reported cases it would appear that, as in other melanomas, prognosis is inversely related to depth of invasion at the time of diagnosis. The need for several biopsies or for total excision to make a definitive diagnosis of suspicious pigmented lesions of the hands or feet is noted both in a review of the literature and in the case presented.

Biopsy↗
PubMed1980

Port wine stains and the response to argon laser therapy: successful treatment and the predictive role of color, age, and biopsy.

To date, no criteria exist for anticipating the response of a port wine stain to argon laser therapy. In an effort to determine such predictive factors, the preceding study was undertaken. Sixty-two patients, ages 7 to 66 years, with port wine stains were biopsied, had a small test area treated, and were evaluated after 4 months. A desirable result, defined by marked lightening of the lesion without scarring, occurred in 73 percent of the patients. Factors favoring a desirable result included age greater than 37 years, purple color, fraction of dermis occupied by vessels greater than 5 percent, mean vessel area greater than 2500 micrometers2, and percent of vessels containing erythrocytes greater than 15 percent. Furthermore, the degree of color change strongly correlated with these indices. Factors indicating an undesirable result included age less than 17 years, pink color, vascular area less than 2 percent, mean vessel area less than 1500 micrometers2, and percent of vessels containing erythrocytes less than 3 percent, Thus, if appropriate clinical and histological criteria are met port wine stains can successfully treated with argon laser therapy.

Adolescent↗
PubMed1980

The nature and evolution of port wine stains: a computer-assisted study.

In an attempt to understand the histogenesis and evolution of port wine stains (PWS), 100 patients with PWS were biopsied; the gross features of each lesion and the patient's associated clinical characteristics were recorded. A detailed analysis of each biopsy including both vessel and nonvessel parameters was made with the assistance of a computer. The central abnormalities characterizing port wine stains are an increase in vessel number (vascular profiles) and ectasia. Vessel number is highest in the immediate subepidermal area and then rapidly diminishes; mean vessel depth is .46 +/- .17 mm. In contrast mean vessel area shows less variation throughout the dermis, ectatic vessels being present when vessel number is very low. The product of both factors determines the percent of dermis occupied by vessels, but the mean vessel area is the major determinant. While age correlates poorly with vessel number, it correlates well with both progressive vessel ectasia and color shifts (pink to purple). Each of multiple vessel parameters analyzed (vessel number, mean vessel area, wall thickness, angulation, and luminal erythrocyte content) exhibited strong layer to layer correlation within the first .8 mm of tissue beneath the epidermis, indicating homogeneity of vessel characteristics within the lesion. The size of the lesion and facial quadrant distribution do not change with age nor are they related to any histological parameters. However the PWS lesion is found most often on the right side and lower quadrants, with a distinctive pattern being present in patients with glaucoma and mental retardation.

Adolescent↗
PubMed1979

Cutaneous lymphoma masquerading as granuloma faciale.

Granuloma faciale is a presumably benign disorder of the skin--usually of the face--characterized by a dense, polymorphous, inflammatory infiltrate including numerous eosinophils, separated from the epidermis by a clear or "grenz" zone, and possessing a small vessel, leukocytoclastic vasculitis. Primary malignant lymphoma of the skin, other than mycosis fungoides, is an unusual entity that may follow a widely variable course and is often extremely difficult to diagnose definitively. A patient is presented in whom a lesion consistent with granuloma faciale changed its histological appearance and clinical behavior into that of a malignant lymphoma.

Face↗
PubMed1978

Combination chemotherapy followed by skin grafts in the management of locally advanced breast cancer.

A combined modality approach to the treatment of locally advanced, ulcerating carcinoma of the breast is discussed. The beneficial effects of combination chemotherapy have been amplified by split thickness skin grafts at the site of a large skin deficit, resulting in successful wound palliation. Criteria for assessing likelihood of graft acceptance by an ulcerating wound in the presence of local neoplastic disease are emphasized.

Breast↗
PubMed1978

The problem of adherence in dressed wounds.

Adherence of the wound dressing is an avoidable problem. Use of the three layered dressing, proper construction of the dressing, knowledgeable and judicious selection of dressing components and reasonably frequent changing of dressings will prevent adherence from developing.

Adhesiveness↗
PubMed1976

The mechanism of capillarity in surgical dressings.

By appreciating the concept of capillarity and by determining whether or not the dressing to be used next to the wound should be hydrophilic or hydrophobic, a dressing can be designed that acts to remove secretions from a draining wound. It also may protect a wound from exogenous secretions.

Bandages↗
PubMed1975

Advantages of double releases in axillary, antecubital and popliteal contractures.

The advantages of the double release technique in axillary contractures are discussed. The procedure is useful for releasing contractures involving the antecubital and popliteal spaces as well. The risk of cutting vital structures involved in the scar tissue is minimized; also, the skin in the center of the axilla, if infected or ruptured, can be covered without as much threat to the axillary space. In addition, by placing the skin grafts on the surfaces at edges of the antecubital or in the popliteal space, the take of the skin graft on a flat surface is better insured.

Axilla↗