Biomedical subjects

J M Meis

Publications and source records attributed to J M Meis.

41 records · Page 3Linked to original sources

PubMed1986

Liposarcoma of the larynx. Case report and literature review.

Primary liposarcoma of the larynx is extremely rare. To our knowledge, only eight cases have been documented in the English literature. We report a ninth case in a 54-year-old man. The recurrent 2-cm tumor was well differentiated and was treated with a supraglottic laryngectomy with partial neck dissection followed by radiotherapy. There has not been a second recurrence in 16 months. The majority of liposarcomas arising in the larynx have been of a favorable histologic type (well differentiated or myxoid). The tumor tends to occur in a supraglottic location in men of 40 years or more, and multiple recurrences are typical. The primary mode of treatment is wide surgical excision, with or without postoperative radiation therapy.

Combined Modality Therapy↗

PubMed1986

S-100 protein and myoepithelial neoplasms.

Besides advancing our knowledge of histogenesis, immuno-cytochemical studies of salivary gland tumors have added an important objective component to the diagnosis and classification of the tumors. Cellular localization of S-100 protein now allows identification of myoepithelial cells and tumors composed of these cells. The four tumors presented in this report illustrate the diagnostic advantages afforded by S-100 protein immunocytochemistry.

Adult↗

PubMed1986

A comparative marker study of large cell lymphoma, Hodgkin's disease, and true histiocytic lymphoma in paraffin-embedded tissue.

A comparative study of large cell lymphoma (LCL) (ten B and ten T), Hodgkin's disease (15 cases), and true histiocytic lymphoma (two cases) was undertaken, using formalin-fixed paraffin-embedded tissue sections, a panel of eight antibodies, and one lectin to determine if any particular antibody or immunologic profile could reliably distinguish between these entities. The antibodies used were against Leu-M1, alpha-1-anti-chymotrypsin (alpha-ACT), alpha-anti-trypsin (alpha-AT), lysozyme, kappa, lambda, leukocyte common antigen (LCA), and S-100 protein. The lectin used was peanut agglutinin (PNA). Although Leu-M1 staining was positive in 11 of 15 cases (73%) of Hodgkin's disease, it was also positive in 4 of 10 cases (40%) of T-cell lymphoma, 2 of 10 cases (20%) of B-cell lymphoma, and 1 of 2 cases (50%) of true histiocytic lymphoma. Peanut-agglutinin staining results were similar to Leu-M1. The only staining profile that emerged was the presence of Leu-M1, PNA-, alpha-ACT, and alpha-AT staining in Reed-Sternberg (RS) cells in 11 of 15 cases of Hodgkin's disease. Leu-M1 and its staining pattern is characteristic, but not entirely specific for RS cells, and it was not positive in at least 25% of the cases of Hodgkin's disease in formalin-fixed, paraffin-embedded tissues. The limitations of this antibody and others should be recognized.

Antigens, Neoplasm↗

PubMed1986

Meningiomas. An immunohistochemical study of 50 cases.

Fifty formalin-fixed, paraffin-embedded meningiomas were studied with a panel of ten antibodies directed against epithelial antigens, intermediate filaments, and neuroectodermal antigens. Twenty-five (50%) of these were stained with monoclonal antibodies (MoAb) to epithelial membrane antigen (EMA), 12 (24%) with keratin antibodies, 9 (18%) for vimentin, and 4 (8%) for S100 protein. Monoclonal antibodies to Leu-7, desmin, neurofilament 200 kDa, and glial fibrillary acidic protein (GFAP) all failed to stain any of the 50 neoplasms. Overall, 34 (68%) meningiomas stained with one or more antibodies. Sixteen (32%) failed to stain at all. The dual epithelial and mesenchymal nature of meningiomas is supported in this study. Applications to diagnostic surgical pathology and histogenetic implications are discussed.

Antibodies, Monoclonal↗

PubMed1985

Intimal hyperplasia as a cause of restenosis after percutaneous transluminal coronary angioplasty.

We describe a patient who died 96 days after percutaneous transluminal coronary angioplasty was performed. The balloon-dilated segments of the left anterior descending artery and its first diagonal branch were found to be restenosed. Histologic examination of these arterial segments showed intimal hyperplasia without lipid deposition as the cause of restenosis, rather than common atherosclerotic plaque.

Angioplasty, Balloon↗