Biomedical subjects
Publications and source records attributed to J M Meinhold.
A case of diffuse, erythematous, pruritic, maculopapular eruption which occurred on a limited, identical body surface with each administration of 2 different brands of lithium carbonate is reported. Clinicians should be aware of the possibility of this type of eruption occurring when prescribing lithium carbonate to patients.
Conditions affecting the decision of whether to take a census or a sample; the major types of sampling procedures, both probability and nonprobability;; and the statistical approaches to sample size determination for simple random samples are discussed. An overview of selected terms and symbols used in sampling literature and a checklist of basic questions to guide a researcher interested in using sampling for a study are provided. While the researcher can control sampling error by increasing the sample size, the concern should be the magnitude of the total error for the study (both sampling and nonsampling errors).
The use of heparin sodium and warfarin sodium in the treatment of pulmonary embolus (PE), deep vein thrombosis (DVT) and thrombophlebitis (TP) was studied by a hospital pharmacy department. During a four-month period, the charts of 26 patients were audited for anticoagulant dosages used; laboratory test monitoring of anticoagulant dosage used; laboratory test minitoring of anticoagulant therapy; complications of, contraindications to, and patient compliance with anticoagulant therapy. These variables were evaluated on the basis of compliance with a written anticoagulant protocol. Initial doses of heparin sodium and warfarin sodium were acceptable in 43% of patients. Maintenance dosing with heparin sodium was acceptable in 89% of patients. Activated partial thromboplastin times (APTT) were ordered correctly for 65% of patients. APTTs were within therapeutic ranges in 31% of patients. The duration of heparin-warfarin overlap was possibly to definitely acceptable in 71% of patients. Prothrombin times were properly monitored in 50% of patients. Complications of anticoagulant therapy were evident in only one patient. There were a number of potentially serious diversions from the protocol. The pharmacy department planned to issue bulletins designed to correct the problems.
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The bioavailability of two lithium carbonate products was studied in ten healthy, normal volunteers. The results indicate that there is no significant difference in bioavailability of the two brands, but some individual differences may exist. Further study is therefore indicated in this area.