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Biomedical subjects

J M Martin

Publications and source records attributed to J M Martin.

At least 217 records · Page 12Linked to original sources
PubMed1971

Further modification of a technique for radioimmunoassay of insulin.

Since our original report we adapted a modification of the immunoassay procedure that increased the sensitivity and reproducibility of the assay. The differences between the present procedure and the previous one are: (a) an initial 20 hour incubation period before the addition of the tracer insulin, and (b) incubation at 37 degrees C instead of 4 degrees C. The adapted method resulted in standard curves of similar slope for bovine, porcine, rhesus monkey, canine and human insulin. The validity of the assay for bovine insulin was established by recovery and dilution experiments.

Animals↗
PubMed1970

Hormonal and metabolic studies in pheochromocytoma.

One patient with benign and another with malignant pheochromocytoma have been studied in an attempt to elucidate the effect of increased catecholamines on the response of blood sugar, unesterified fatty acids, insulin and growth hormone to a glucose load. The presence of increased catecholamines in both patients appeared to produce increased fasting plasma unesterified fatty acid levels, carbohydrate intolerance and an unusual plasma growth hormone response to glucose. There was no interference with the normal decrease in plasma unesterified fatty acids after glucose ingestion. The malignant tumour, but not the benign one, was associated with low plasma insulin levels.After removal of the benign tumour the fasting unesterified fatty acid levels became normal. In addition, following glucose ingestion there appeared to be a more normal plasma insulin and growth hormone response and improved glucose tolerance. After removal of the primary malignant tumour it is noteworthy that the distant metastases secreted abnormal amounts of both adrenaline and noradrenaline.

Adrenal Gland Neoplasms↗