Search PubMed⌕ Search

Biomedical subjects

J M Marks

Publications and source records attributed to J M Marks.

69 records · Page 4Linked to original sources
PubMed1981

Personal solar UV-A doses received by patients undergoing oral psoralen photochemotherapy for psoriasis.

Patients undergoing oral psoralen photochemotherapy (PUVA) for psoriasis receive a known amount of UV-A in the treatment cubicle and an unknown amount of UV-A from sunlight. In order to measure the solar UV-A dose, fifty-six patients received a UV-sensitive film badge to be worn from the time they took their psoralen tablet throughout the course of the day, except during treatment. The UV-A doses measured in this way varied from less than 0.2 J cm-2 to 7 J cm-2, with a median of around 1 J cm-2. These results show that the solar UV-A received by patients who have been photosensitized by 8-MOP may not be insignificant in relation to the treatment dose.

Film Dosimetry↗
PubMed1980

Paget's disease.

The dentist may recognize Paget's disease before either systemic manifestations on complications occur. Suspicion may arise through routine oral and radiographic examination as pathologic conditions usually occur first in the jaws and skull. As with any disease, early recognition is helpful in treatment and may necessitate alterations in the proposed dental treatment.

Adult↗
PubMed1980

Psoriasis: utilising the treatment options.

Psoriasis varies so much in severity and clinical pattern that there is no 'best' treatment. Topical treatment with dithranol, tar or wisely used corticosteroids is preferable to systemic treatment, except in severe forms of psoriasis where systemic corticosteroids or antimitotic drugs, especially methotrexate, may be necessary. Photochemotherapy with PUVA has come to stay and can certainly be used as first-line treatment in those with extensive plaque psoriasis who are over 60 years of age. Its role in treating younger patients is still being asssssed, particularly with regard to possible long term side effects, but it is likely that eventually its use will be extended.

Adrenal Cortex Hormones↗
PubMed1978

Absence of cutaneous IgA in coeliac disease without dermatitis herpetiformis.

Skin biopsies from 17 patients with coeliac disease, but without dermatitis herpetiformis, were examined by direct immunofluorescence. In none of them was IgA detectable. In contrast, IgA was present in dermal papillae and/or in relation to the dermo-epidermal junction in 80 out of 83 patients with dermatitis herpetiformis. These findings confirm that cutaneous deposition of IgA at these sites is a very characteristic feature of dermatitis herpetiformis and is unrelated to coeliac disease itself.

Adult↗
PubMed1971

Incidence of small-intestinal mucosal abnormalities and of clinical coeliac disease in the relatives of children with coeliac disease.

Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absence of any simple Mendelian pattern of inheritance: in place of the hypothesis that inheritance is through a dominant gene of reduced penetrance, it is argued that the pathogenesis of coeliac disease is multifactorial, the genetic basis of susceptibility being polygenic and interacting with environmental factors. On this hypothesis the relative contributions of inheritance and environment to liability to the clinical condition are estimated, the genetic component being 45% +/- 9. Environmental factors appear more important in the development of mucosal abnormality.

Adult↗