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Biomedical subjects

J M Manners

Publications and source records attributed to J M Manners.

71 records · Page 4Linked to original sources
PubMed1979

Beta-adrenoceptor blockade and anaesthesia. Beta-adrenoceptor antagonism during anaesthesia for coronary artery surgery.

Twenty-six patients with severe coronary artery disease, receiving long term beta-adrenoceptor blocking drugs were anaesthetised for aorto-coronary bypass operations. Beta-adrenoceptor blocking drugs were withdrawn 2 to 8 days before surgery in ten patients only. In the remaining sixteen patients there were no serious complications due to the presence of a degree of beta-blockade during anaesthesia and surgery. The undesirable cardiovascular responses to laryngoscopy and tracheal intubation were diminished in these patients, and the rise in heart rate/systolic pressure product, and indicator of myocardial oxygen consumption, was less in this group. The need for peripheral vasodilators to treat systemic arterial pressure rises in response to surgery was also reduced. There appeared to be no contraindication to the continuation of beta-adrenoceptor blockade before operation in patients undergoing aorto-coronary bypass procedures when suitable anaesthetic agents were selected and when an appropriate blood volume was maintained.

Adrenergic beta-Antagonists↗
PubMed1979

Valve replacement in carcinoid syndrome. Anaesthetic management for tricuspid and pulmonary valve surgery.

This report describes the anaesthetic management of a patient with carcinoid syndrome for cardiac catheterisation followed by replacement of the tricuspid and pulmonary valves. Apart from the precautionary use of aprotinin and steroids, routine techniques of anaesthesia and monitoring were used without complications attributable to secretions from tumour tissue.

Anesthesia, General↗
PubMed1977

Pulmonary arterio-venous fistula. A shunt equation exercise during thoracotomy.

A report is given of a patient with multiple bilateral pulmonary arterio-venous fistulae who underwent right thoracotomy for this condition. Blood-gas studies before and during surgery showed that the arterio-venous oxygen content differences of 1-16-1-34 mmol/l were less than normal, and the calculated venous admixture during the procedure varied from 44 to 60% of cardiac output. The changes in venous admixture at various stages of the operation could not be predicted on the basis of evidence derived from normal lungs.

Adult↗
PubMed1977

Pulmonary hypertension in mitral valve disease: 56 surgical patients reviewed.

A total of 392 patients have undergone prosthetic valve surgery including the mitral valve over a four-year period (1972-76). Of these patients 56 (14%) had a pulmonary artery systolic pressure of 70 mmHg or more during preoperative cardiac catheterisation and the hospital mortality of this group was 5.4%. Similarly, the hospital mortality of the remaining 336 patients with a pulmonary artery pressure below 70 mmHg was 5.4%. The presence of pulmonary hypertension in patients with valve disease including the mitral valve does not therefore indicate that the risk of dying in hospital as a consequence of corrective surgery is increased. The absence of a raised hospital mortality in this recent series may be attributed to improved surgical techniques and materials, while the use of droperidol and pentolinium which may reduce pulmonary vascular resistance as well as systemic resistance during surgery could be contributory.

Adult↗
PubMed1976

Venous air embolism during neurosurgery. A comparison of various methods of detection in man.

A comparison of the various methods available for the detection of air embolus has been carried out in patients undergoing posterior fossa exploration in the sitting position. A group of 17 patients (Group A) was comprehensively monitored by a central venous catheter, an infra-red carbon dioxide analyser and a Doppler ultrasonic flow transducer in addition to more traditional clinical methods. Group B (19 patients) was monitored by commonly used clinical methods consisting of continuous palpation of the radial pulse, intermittent blood pressure measurement, the use of an oesophageal stethoscope and the electrocardiograph. In Group A the detection of air embolus varied from 6% using an oesophageal stethoscope to 58% by the Doppler method. In Group B air embolus was diagnosed in 10% of patients. One patient in each group died from air embolus; one patient had a paradoxical embolus to the coronary arteries. It is concluded that comprehensive monitoring for air embolus, including the use of Doppler ultrasound, is an essential part of the management of these patients, for both diagnosis and treatment.

Adult↗
PubMed1976

A new tube feed: Aminutrin and Calonutrin.

A new tube feed made up from separate sachets of 1-amino acids and saccharides, and mixed with milk, has been given to five patients for a total of 49 days. The preparation, administration and tolerance of the feed has been uncomplicated, and the electrolyte, calorie and nitrogen content could be easily varied according to the patient's needs. A simple metabolic study of the patients was made during the administration of the feed.

Adult↗
PubMedDate not supplied

Differential expression of peroxidase isogenes during the early stages of infection of the tropical forage legume Stylosanthes humilis by Colletotrichum gloeosporioides.

Infection of Stylosanthes humilis by the fungal phytopathogen Colletotrichum gloeosporioides is associated with an increase in peroxidase enzyme activity within 24 h postinoculation. Peroxidase gene expression was investigated as a first step towards understanding the regulation and functional importance of this host response to fungal attack. Four distinct cDNAs Shpx 2, 5, 6, and 12, isolated from a cDNA library of S. humilis contained deduced amino acid (aa) sequence motifs characteristic of peroxidases. Three of these (Shpx 2, 5, and 6) were full-length and their deduced proteins each fell into a different homology group based on comparisons with other plant peroxidases. Each cDNA appeared to hybridize to only one or two genes in S. humilis. mRNAs corresponding to Shpx2, Shpx6, and Shpx12 were expressed relatively abundantly in young leaves, with lesser expression of Shpx2 and Shpx6 and no expression of Shpx12 detected in roots. No expression of these genes was detected in stems or old leaves. The mRNA of Shpx5 was relatively abundant in stems and to a lesser extent in young leaves. However, infection of young leaves with C. gloeosporioides greatly increased expression of the mRNAs of Shpx2 and Shpx6 but not Shpx5 nor Shpx12 compared to mock-inoculated controls. The mRNA of Shpx6 was strongly induced by the pathogen 4 h postinoculation, a time which precedes fungal penetration, while Shpx2 was induced to higher levels than controls at 24 h after inoculation. The mRNAs of both Shpx2 and Shpx6 but not Shpx5 and Shpx12 were also induced by wounding.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMedDate not supplied

Intermittent assisted ventilation. An assessment using the Retec breathing assistor.

A simple ventilator assistor was utilised in three of six patients after transthoracic repair of hiatus hernia. The device was found to be easy and convenient to use but in the pilot study produced no demonstrable improvement in respiratory function. At 10 days postoperation, the arterial oxygen tension had not risen to a preoperative level in five patients, and the FVC and FEVI were less than the values obtained before surgery in every patient.

Aged↗