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Biomedical subjects

J M Mann

Publications and source records attributed to J M Mann.

At least 19 recordsLinked to original sources
PubMed1999

Price competition and hospital cost growth in the United States (1989-1994).

In recent years, most health care markets in the United States (US) have experienced rapid penetration by health maintenance organizations (HMOs) and preferred provider organizations (PPOs). During this same period, the US has also experienced slowing health care costs. Using a national database, we demonstrate that HMOs and PPOs have significantly restrained cost growth among hospitals located in competitive hospital markets, but not so in the case of hospitals located in relatively concentrated markets. In relative terms, we estimate that HMOs have contained cost growth more effectively than PPOs.

Economic Competition↗
PubMed1998

Histological patterns of atherosclerotic plaques in unstable angina patients vary according to clinical presentation.

BACKGROUND: Unstable angina is a heterogeneous clinical syndrome. The diverse clinical presentations of unstable angina may reflect different pathogenic mechanisms within the plaque. OBJECTIVE: To investigate the cellular constituents of culprit coronary atheromatous plaques in patients with stable angina pectoris and patients with diverse clinical presentations of unstable angina. METHODS: 48 patients who underwent coronary atherectomy for management of ischaemic heart disease: 23 had stable angina and 25 had unstable angina. Of the latter, 11 patients were classified as Braunwald's IIB and 14 as Braunwald's IIIB unstable angina. The presence of thrombus, cholesterol clefts, and smooth muscle cell proliferation was assessed in atherectomy samples using standard histological techniques. Monoclonal antibodies were used to identify smooth muscle cells and macrophages within atherosclerotic plaque fragments. RESULTS: Fresh thrombus was more frequently found in patients with Braunwald's IIIB unstable angina (64%) than in patients with stable angina (22%) or IIB unstable angina (27%) (p < 0.0006). A pattern of smooth muscle cell proliferation ("accelerated progression pattern") was observed which was also associated with coronary thrombus. This pattern was present in 30% of patients with stable angina, 64% of patients with IIIB unstable angina, and in all patients (100%) with IIB unstable angina. Atherosclerotic plaques with thrombus, cholesterol clefts, and macrophages were more common in patients with unstable angina than in stable angina patients. CONCLUSION: The presence of a specific smooth muscle cell proliferation (accelerated progression) pattern in patients with unstable angina, particularly in those with Braunwald's IIB unstable angina, suggests that episodic plaque disruption and subsequent healing may be an important mechanism underlying angina symptoms in these patients.

Adult↗
PubMed1997

Weight bearing and velocity in trans-tibial and trans-femoral amputees.

The purpose of this study was to review the clinical utility of static weight bearing (SWB) and maximal self-selected ambulatory velocity as objective quantifiable measures in an outpatient lower limb prosthetic clinic. Seventy-three (n = 73) consecutive trans-tibial (TTA) and trans-femoral amputees (TFA) attending an outpatient prosthetic clinic were studied. Prosthetic weight bearing was measured on a bathroom scale (mass in kg), normalised to body mass then expressed as a percentage and labelled static weight bearing (SWB). Maximum safe self-selected ambulatory velocity over a 10 metre level walkway (m/s) was measured with a stopwatch. The SWB mean for the TTA group was 94.93% range 77-100%) and 88.36% for the TFA group (range 43-100%). The mean ambulatory velocity was 1.70 m/s (range 0.07-5.75) for the TTA group and 0.78 m/s (range 0.10-1.54) for the TFA group. A statistically significant relationship (p < 0.05) was found between SWB and ambulatory velocity in trans-tibial and trans-femoral amputees in this study. A ceiling effect was noted in the trans-tibial group with 42% achieving 100% SWB through their prosthetic limb so it was concluded that ambulatory velocity was the more sensitive measure in established trans-tibial prosthetic limb users. SWB may be the more appropriate quantifiable measure for use in established trans-femoral prosthesis users. Prosthetic training programmes would benefit from the objective measurement of SWB. Once optimal SWB was achieved, ambulatory velocity would be the more sensitive measure of prosthetic use.

Adolescent↗
PubMed1996

Global expansion of HIV infection and AIDS.

The decline of new HIV infections among subgroups in industrialized countries has created a false sense of security; globally, about 13,000 new infections occur each day. In developing countries, limited health care spending bars all but a privileged few from access to new treatment. In the absence of an effective vaccine and intensified prevention, spread of the virus will continue unabated.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Vulnerable plaque. Relation of characteristics to degree of stenosis in human coronary arteries.

BACKGROUND: The microanatomic features of the atherosclerotic plaque at risk of disruption include a large lipid core, a high macrophage content, and a thin cap. The relation between lipid core size, plaque size, and cap thickness either with each other or with the degree of stenosis has yet to be evaluated in human coronary arteries. METHODS AND RESULTS: Atherosclerotic coronary plaques (n = 160) were obtained from 31 subjects who died suddenly of ischemic heart disease. In coronary arteries perfused with formol saline at a pressure of 100 mm Hg, stenosis was measured by comparison of the minimal lumen size at the site of a plaque with that of the lumen in an adjacent normal segment of artery. Plaque size, the size of the lipid core, and the thickness of the cap were measured in histological sections. Lipid core size ranged from 0% to 82% of overall plaque size. Seventeen percent of plaques had a core size of > 50%. Linear regression showed no relation of core size to stenosis (r = .21). Absolute plaque size bore no relation to core size (r = .14). Minimal cap thickness was not related to core size (r = .06). Ten percent of plaques predicted to be angiographically invisible had cores of > 50%. CONCLUSIONS: Two major determinants of plaque vulnerability, core size and cap thickness, are not statistically related. Neither of these two factors that confer vulnerability are related to absolute plaque size or to the degree of stenosis.

Aged↗
PubMed1996

Propofol and alfentanil for sedation during placement of retrobulbar block for cataract surgery.

STUDY OBJECTIVE: To determine if the addition of alfentanil to propofol is more effective than propofol alone to provide adequate conditions for placement of a retrobulbar block prior to cataract surgery. DESIGN: Randomized, double-blinded study. SETTING: Outpatients at a university hospital. PATIENTS: 40 adult ASA physical status I, II, and III outpatients scheduled for elective cataract surgery. INTERVENTIONS: Patients were randomly assigned to receive one of four drug combinations prior to the placement of a retrobulbar block: Group 1, propofol alone; Group 2, alfentanil 5 micrograms/kg plus propofol; Group 3, alfentanil 10 micrograms/kg plus propofol; Group 4, alfentanil 15 micrograms/kg plus propofol. All patients were preoxygenated by face mask for two minutes prior to drug administration. The quality of conditions for block placement were determined by: (1) assessing the amount of movement by the patients while the block needle was in place, (2) cooperativeness of the patients during the operation, (3) hemodynamic side effects, (4) incidence and severity of respiratory depression, (5) incidence of nausea and vomiting, (6) recall of placement of the block, and (7) time to discharge from the hospital. MEASUREMENTS AND MAIN RESULTS: The addition of alfentanil to propofol for sedation prior to placement of the retrobulbar block resulted in a dose-dependent reduction in movement by the patients. However, the highest dose of alfentanil (15 micrograms/kg) resulted in the greatest frequency (40% of the patients in this group) of respiratory depression (SpO2 < 90%). All patients were cooperative during the operation and responsive to verbal command within 5 minutes of placement of the block. In addition, all of the patients denied being nauseated, having vomited, or recalling block placement in the recovery room or the next day. CONCLUSIONS: The combination of alfentanil and propofol may be used to sedate patients in order to limit movement and provide a cooperative, alert patient with stable hemodynamics and limited respiratory depression during placement of retrobulbar block prior to ophthalmic surgery. However, excessive dosage of these drugs may result in hazardous respiratory depression in this patient population.

Aged↗
PubMed1995

Perceived necessity explains the dissociation between logic and meaning: the case of "only if".

The purpose of this article was to investigate why sentences of the form "p only if q" often appear to have a different meaning than sentences of the form "if p, then q," despite their logical equivalence. The results of 3 experiments indicate that when "if ... then" statements were equated with respect to necessity and temporal relations, different pragmatic relations (such as permission, causation, etc.) elicited similar "only if" judgments. However, different necessity relations elicited different "only if" judgments, regardless of the type of pragmatic relation expressed in the "if then" statement. These data suggest that "only if" judgements are primarily mediated by necessity and temporal relations and that pragmatic contexts may play a more indirect role, such as in the interpretation of necessity and temporal relations. Suggestions for how these findings might be incorporated into pragmatic schema theory (P. W. Cheng & K. J. Holyoak, 1985; P. W. Cheng, K. J. Holyoak, R. E. Nisbett, & L. M. Oliver, 1986) and mental models theory (P. N. Johnson-Laird & R. M. J. Byrne, 1991) are discussed.

Dissociative Disorders↗
PubMed1995

Assessment of the severity of coronary artery disease at postmortem examination. Are the measurements clinically valid?

OBJECTIVE: To compare the assessment of severity of coronary artery stenosis by the conventional pathology methods with a method designed to resemble quantitative angiography. DESIGN: 31 human hearts harvested at necropsy were fixed by perfusion of the aortic root with 10% formol saline at 120 mm Hg for 24 hours. The right coronary and left anterior descending coronary arteries were transversely sliced every 2 mm and the absolute lumen dimensions plotted against the distance from the coronary ostium. Stenosis figures were calculated by comparing the lumen diameter with the lumen diameters in adjacent normal arterial segments in a manner identical to that used in angiographic measurement. The coronary artery segments were then processed histologically. Stenosis was then remeasured by comparing the lumen diameter with the diameter of the vessel within the internal elastic lamina identified by elastic van Gieson staining. RESULTS: Compared with the method that was analogous to angiography, the pathology method used on histological slides overestimated the degree of stenosis by 25-30%. The lack of concordance between the methods was not a function of the severity of the stenosis. CONCLUSION: When they read necropsy reports in which the severity of coronary artery stenosis is assessed cardiologists should be aware of the discrepancy between clinical and pathological methods.

Coronary Angiography↗
PubMed1994

Evidence from family studies for autoimmunity in dilated cardiomyopathy.

Organ-specific antibodies are found in patients with autoimmune disease and their symptom-free relatives many years before clinical onset. Organ-specific cardiac antibodies can be found in patients with dilated cardiomyopathy (DCM) and their relatives, which supports the idea that DCM is an autoimmune disease. We did non-invasive cardiological assessment and antibody screening in 342 symptom-free relatives (170 male, 172 female, mean [SD] age 31 [16] years). 177 relatives were from 33 families with more than 1 affected individual (familial DCM) and 165 relatives from 31 families with only 1 affected member (non-familial DCM). The frequency of cardiac antibodies was higher among relatives of DCM patients than in controls (20% vs 3.5%, p = 0.0001). In 37 (58%) of the families studied, cardiac antibodies were found in the proband and/or in at least 1 family member and were more common in familial than in non-familial DCM (24% vs 15%, p = 0.036). Antibody-positive relatives were younger (26 [15] vs 33 [17] years, p = 0.01) and had a larger mean echocardiographic left ventricular end-systolic dimension (35 [6] vs 32 [6], p = 0.01 mm) and reduced percentage fractional shortening compared with antibody-negative relatives (31 [6] vs 34 [6], p = 0.008). Presence of cardiac-specific autoantibodies in symptom-free DCM relatives provides evidence of autoimmunity in a subset of our patients (58%), including familial and non-familial forms of DCM. These antibodies are associated with mild left ventricular systolic dysfunction on echocardiography and may be early markers for relatives at risk of DCM.

Adult↗