Search PubMed⌕ Search

Biomedical subjects

J M Mallion

Publications and source records attributed to J M Mallion.

219 records · Page 13Linked to original sources
PubMedDate not supplied

[Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination].

This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in). A significant fall of systolic (SBF) and diastolic (DBP) blood pressure at rest was seen after a 4-week treatment period in the two active groups (-21.9/-10.3 mmHg with BZ 10, -19.5/-11.2 mmHg with BZ + HCTZ) and was greater in these two groups than in the placebo group (-7.5/-2.5 mmHg, p < 0.01). For each level of the exercise test on bicycle ergometer, SBP falls seen after 1 month were significant in the two active groups (from -15 to -23 mmHg depending on the level and treatment group). The evolution of the SBP/heart rate slope was significantly different among the two active groups in favour of the BZ 10 regimen. The exercise test proved to be a valuable tool to show any difference between two treatments with comparable efficacy on SBP/DBP at rest.

Adolescent↗
PubMedDate not supplied

Drug-induced changes in ambulatory blood pressure and pulse pressure in patients with or without sustained hypertension.

We retrospectively studied 216 mild to moderate hypertensive patients receiving either an angiotensin converting enzyme inhibitor (ACEI) or a calcium antagonist (CA), as a once-a-day monotherapy; their blood pressure had been measured using both a sphygmomanometer and an ambulatory blood pressure recorder. Numerous discrepancies were found between the two methods of blood pressure measurement with respect to systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as pulse pressure (PP). Clinic blood pressure measurement did not show any significant differences between the effects of ACEI and those of CA, whereas ambulatory blood pressure measurements (ABPM) showed that in patients with normal ambulatory blood pressure (so-called 'white coat' hypertensive patients), ACEI only (but not CA) significantly lowered SBP, DBP and PP. Accordingly, a threshold of efficacy was sought: it appeared to be lower for ACEI than for CA (120/80 vs 140/85 mmHg). Furthermore, for a given degree of DBP lowering, SBP and PP were more lowered by ACEI than by CA, indicating a greater effect of ACEI on arterial compliance. Likewise, for a given level of mean blood pressure, SBP and PP were lower and DBP slightly higher in patients on ACEI than in those on CA. Our data are consistent with some recent papers, emphasizing a heightened activity of the renin-angiotensin system in 'white coat' hypertensive patients.

Adult↗