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Biomedical subjects

J M Lynch

Publications and source records attributed to J M Lynch.

At least 91 records · Page 5Linked to original sources
PubMed1990

Power-sharing in lesbian partnerships.

This study of 70 lesbian couples explored whether partners who characterized certain aspects of their relationships as equal in power-sharing were similar in age, income, education, and financial assets, while those who viewed their power-sharing as unequal would be dissimilar on these social status variables, and, second, whether or not most lesbian couples considered their relationships as egalitarian. Power-sharing was assessed through a number of questionnaire items, and snowball sampling was utilized. Three types of couples emerged: (a) equal, (b) unequal but in agreement about who had more power, and (c) couples with differing perceptions about power-sharing. The findings indicated that power-sharing arrangements could not be explained by age, income, education, and asset differences between partners. Egalitarianism was the ideal in most relationships, but had not been achieved to the same degree in each of the areas investigated.

Adult↗
PubMed1989

Performance of cows in early lactation fed isonitrogenous diets containing soybean meal or animal by-product meals.

Eighty primiparous cows were assigned to either soybean meal, fish meal, or A and B treatments. Commercial supplement A was a blend of meat and bone, meat, poultry, blood, and feather meals. Commercial supplement B included the same ingredients as A but had a higher amount of blood meal and also a low concentration of fish meal. In vitro undegradabilities of protein were 32.0, 37.8, 38.8, and 42.4% for soybean meal, fish meal, A, and B rations, respectively. Milk yields and body weight changes were not significantly affected by treatments. Because of the lower milk fat content on fish meal diet, FCM yield was lower for cows fed fish meal than soybean meal or B supplements. Milk protein content was 3.19, 3.19, 3.03, and 3.09% on soybean meal, fish meal, A, and B diets, respectively. The calculated protein efficiency (100* output/input) on soybean meal, fish meal, A, and B diets were 47.8, 51.6, 45.9, and 48.7, respectively. The undegraded protein in the fish meal after an 18-h in vitro incubation with protease enzyme (Streptomyces griseus, type V) had a higher concentration of methionine and lysine than the undegraded protein of other supplements. Flavor of milk produced on the soybean and fish meal diets was evaluated. No flavor differences were detected.

Animal Feed↗
PubMed1988

Avulsion fractures involving the cruciate ligaments.

The evaluation of a child with an acute knee injury is difficult. The injury may be an avulsion fracture involving either of the cruciate ligaments; a common cause is a cycling accident. The amount of fragment displacement dictates the management. Minimal displacement can be treated with immobilization in flexion. Larger displacement requires internal fixation, which can be accomplished arthroscopically. Rehabilitation must be early and aggressive.

Bicycling↗
PubMed1986

The intracellular retention of newly synthesized platelet-activating factor.

The ether phospholipid platelet-activating factor (PAF) has been generally assumed to be released into the extracellular environment by the cells of origin, whereupon it effects its well-known mediator functions. However, during the generation of PAF by human neutrophils, it was noted that the majority of the measurable PAF remained associated with the cells. Accordingly, the intracellular and extracellular distribution of PAF was examined in neutrophils and several other cell types. No PAF was detected in association with unstimulated neutrophils. However, in stimulated neutrophils, PAF was produced and the majority of this material remained in association with the cells independent of the type of stimulus, dose of stimulus, or method of cell isolation used. This pattern of cell association of PAF was seen in all but one of the cell types tested. The retention of PAF by stimulated neutrophils was not due to spurious underestimates of the extracellular levels due to extracellular metabolism and inactivation of released PAF, nor to release followed by readsorption or binding of PAF to the cells. The retention of PAF also occurred in the presence of plasma and appears to be a common phenomenon. Thus, the majority of newly synthesized PAF appears to be retained within the cell and not released.

Adult↗
PubMed1985

A quantitative ELISA procedure for the measurement of membrane-bound platelet-associated IgG (PAIgG).

A quantitative ELISA assay for the measurement of in vivo bound platelet-associated IgG (PAIgG) using intact patient platelets is presented. The assay requires quantitation and standardization of the number of platelets bound to microtiter plate wells and an absorbance curve using quantitated IgG standards. Platelet-bound IgG was measured using an F(ab')2 peroxidase labeled anti-human IgG and o-phenylenediamine dihydrochloride (OPD) as the substrate. Using this assay, PAIgG for normal individuals was 2.8 +/- 1.6 fg/platelet (mean +/- 1 SD; n = 30). Increased levels were found in 28 of 30 patients with clinical autoimmune thrombocytopenia (ATP) with a range of 7.0-80 fg/platelet. Normal PAIgG levels were found in 26 of 30 patients with nonimmune thrombocytopenia. In the sample population studied, the PAIgG assay showed a sensitivity of 93%, specificity of 90%, a positive predictive value of 0.90, and a negative predictive value of 0.93. The procedure is highly reproducible (CV = 6.8%) and useful in evaluating patients with suspected immune mediated thrombocytopenia.

Blood Platelets↗
PubMed1982

Incarcerated congenital diaphragmatic hernias with bowel obstruction (Bochdalek).

Incarcerated congenital diaphragmatic hernias are a rare cause of bowel obstruction in children. In the past 3 yr, we have treated three such diaphragmatic hernias: the first incarcerated and strangulated requiring bowel resection while the other two were incarcerated only. The difficulty in diagnosing this condition in illustrated by these cases. In all children with the triad of upper respiratory illness (URI) or infiltrate on chest x-ray, vomiting, and x-ray evidence of bowel obstruction, the diagnosis of congenital diaphragmatic hernia (CDH) with incarceration and bowel obstruction should be entertained.

Child, Preschool↗
PubMed1981

Gram-negative bacteremias. Analysis of factors for clinical assessment of gentamicin resistance.

We reviewed the charts of 163 patients with 183 episodes of Gram-negative bacillary bacteremia to determine a clinical profile that would select patients at high risk for experiencing gentamicin-sulfate-resistant Gram-negative bacillary bacteremia at our hospital. Gentamicin-resistant Gram-negative bacilli were only associated with institution-acquired bacteremia. Among institution-acquired episodes, urinary tract infection, diagnostic or therapeutic procedures of the lower respiratory tract or urinary tract, presence of pneumonic infiltrate on chest roentgenogram, prior therapy with gentamicin, and prior therapy with other antibiotics were significant risk factors. Because only two of the 29 gentamicin-resistant bacteria that were tested against amikacin base were resistant to amikacin, we advocate initial treatment with amikacin for patients with evidence of an institution-acquired Gram-negative bacteremic episode. Gentamicin is still our initial choice for a community-acquired episode.

Aged↗
PubMed1981

Generalized exfoliation associated with Staphylococcus aureus infection.

A 67-year-old man presented with a rash that was refractory to systemic corticosteroid therapy. Physical examination revealed sloughing skin on his hands, soles, and lower extremities. Stroking involved and uninvolved skin produced Nikolsky's sign. Skin biopsies revealed the plane of cleavage to be in the basal epidermal layer. Cultures of the patient's skin, blood, nose, and throat grew Staphylococcus aureus. These isolates produced an epidermal toxin that caused Nikolsky's sign in neonatal mice. The toxin caused cleavage in the basal epidermal layer of neonatal mice, was heat labile, and was not neutralized by exfoliatin antitoxin.

Aged↗
PubMed1981

Nosocomial Aeromonas hydrophila cellulitis and bacteremia in a nonimmunocompromised patient.

An elderly man, without heat in his home for two days, presented with cold, painful, swollen feet. Second-degree frostbite was present. After having moist packs applied to his feet for five days, the patient became febrile and hypotensive, and wet gangrene necessitated left below-knee and right above-knee amputations. Aeromonas hydrophila was isolated from the patient's blood and cultures of the pedal wounds. An etiologic role of the moist pack therapy is postulated.

Aeromonas↗
PubMed1980

Pseudobacteremia caused by Clostridium sordellii.

Thirteen of 280 (4.6%) blood cultures collected over a 12-day period were positive for Clostridium sordellii, a spore-forming anaerobe, rarely considered a human pathogen. Nosocomial bacteremia and intrinsic contamination of material used to culture blood were excluded as the source of the organism. Contaminated tincture of thimerosal used to swab the rubber stoppers of blood culture bottles prior to venting (aerobic) or during blind subculturing after 24 hours of incubation (anaerobic) in the clinical microbiology laboratory was determined to be the cause of the pseudobacteremia. After appropriate safe-guards were implemented, we have continued to use tincture of thimerosal for these procedures with no further growth of C sordellii from blood cultures. The importance of less-conspicuous steps in the routine processing of culture material have been reemphasized.

Blood Specimen Collection↗