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Biomedical subjects

J M Lera

Publications and source records attributed to J M Lera.

31 records · Page 2Linked to original sources
PubMed1983

[Internal derivation in the treatment of hepatic hydatidosis].

The results of the surgical treatment of human hydatic cyst by cystojejunostomy are presented. This technique was performed in 17,3% of all cysts treated by the authors. The conditions for using technique, as well as it morbidity and mortality are reviewed. The authors' conclusion is that cystojejunostomy is a valid surgical technique for hydatic cyst in some cases in which it is indicated.

Echinococcosis, Hepatic↗
PubMed1982

[Submucosal lipomas of the colon].

Three cases of symptomatic colonic lipoma are presented. All were submucous. Clinical findings were abdominal pain, changes in intestinal rythm and rectorragia. All patients had an important loss of weight, a previously undescribed finding. Two patients had a colonic diverticulosis too. The diagnosis was made by means of radiology (barium enema) and surgery was performed in all cases with excellent results.

Aged↗
PubMed1981

[B cells and serum immunoglobulins in patients with breast pathology].

The authors study the amount of B cells and serum immunoglobulins in patients with mammary cancer or fibrocystic disease. They indicate that a decreasing in B cells and IgG, and an increasing in IgA are associated with a better prognosis. There is an inverse relation between the level of serum IgG and the blastic transformation of T cells by PHA, what is an indirect measure of the circulating IgG immune complexes. The presence of B cells with IgG in their surfaces makes worse the prognosis.

Adult↗
PubMedDate not supplied

[Utilisation of organs proceeding from donors with heart failure: review of the pathogenesis of organic damage and the possible mechanisms of prevention].

There is an evident imbalance between the number of patients awaiting a kidney transplant and the availability of organs proceeding from donors with brain death. A high number of patients die each day from heart failure, whose organs could be used for transplants if specific care is employed. Although centres do exist where these methods of extraction are established, the problems of organic damage have yet to be resolved, since one third of the organs are still lost, besides the increase in the need for early dialysis, and the number of dysfunctioning grafts two years after the transplant, when this type or organ is employed. There is increasingly detailed knowledge of the pathogenesis of organic damage following heart failure and reanimation, as well as of the damage following the conservation and reimplantation of the kidney. Knowledge of the maximum time of hot ischemic that an organ can withstand is of crucial importance if organs are not to be unduly discarded. Besides, the increasing understanding of the physiopathology of oxidative stress could make it possible for us, through the use of antioxidants, to attempt to improve the utilisation of the organs and diminish the incidence of dysfunctions and rejections.

English Abstract↗
PubMedDate not supplied

[Acute cholecystitis: analysis of the different therapeutic approaches in a General Surgery Service during the years 1994-1996].

INTRODUCTION: The commonly accepted approach in the treatment of acute cholecystitis is urgent cholecystectomy. Laparoscopy has renewed interest in the option of "cooling" the inflammatory process, in order to subsequently carry out a programmed cholecystectomy through the technique mentioned. We present an analysis of the data collected on hospital stay and medico-surgical complications in both therapeutic options. The aim of this work is to reflect on the results obtained in the treatment of acute cholecystitis and to evaluate the results of the application of laparoscopic cholecystectomy in the emergency area. MATERIAL AND METHODS: 152 patients diagnosed with acute cholecystitis are studied. They are distributed in 3 groups, analysing the simple and accumulated hospital stay, the index of medical and surgical complications and mortality. RESULTS: Of the 152 patients with a diagnosis of acute cholecystitis, 91 (59.8%) were operated on in their first admission, 47 (30.9%) were treated using "cooling" of the process to be operated on in a second admission and 14 (9.3%) by means of percutaneous cholecystostomy. A total of 29 patients were readmitted, 4 for relapse of acute cholecystitis and 25 for programmed operations. Urgent conventional cholecystectomy shows a greater rate of infections. The cholecystectomy on second admission supposes a moderate increase of the accumulated average stay. 17% of these patients were operated on using open surgery. CONCLUSIONS: Urgent surgery seems the most suitable approach in acute cholecystitis. The employment of laparoscopic surgery in these cases probably reduces the rate of the medical and surgical complications due to laparotomy in infectious acute pathology, and increases the comfort of the patient

English Abstract↗
PubMedDate not supplied

[Present state of the surgical treatment of hepatic metastasis of colorectal origin: a practical view].

Hepatic resection is the only real possibility of cure for a selected group of patients with hepatic metastasis of colorectal cancer. Survival obtained in these patients is of some 30-40% after 5 years and some 20-25% after ten years following surgery; no other treatment approaches these results. The key for obtaining these results is the treatment of these patients by a multidisciplinary team, a team that must include the participation of surgeons specially trained in the techniques of hepatic resection. The present review describes: the pre-operational staging of hepatic metastasis of colorectal origin by diagnostic imaging techniques, the selection criteria for surgery, the standards of the surgical technique and the adjuvant treatment that forms part of the Protocol of the Hepatobiliary Surgery Section of the Hospital of Navarra, based on our experience in 150 hepatectomies and on the best scientifically available evidence.

English Abstract↗
PubMedDate not supplied

Immunologic study of carcinoma of the digestive tract. Influence of tumor staging. II. Humoral immunity in the preoperative period.

The studies of levels of circulating immunoglobulins in cases of solid neoplasia in man have yielded discordant results, especially in cases of colon and rectal cancer. The possible prognostic value of the quantitation of these parameters has been discussed, and some have even suggested that certain fluctuations in immunoglobulin levels may indicate the development of metastases. We studied the behavior of humoral immunity in 88 patients with gastric adenocarcinoma, 63 patients with cancer of the colon and 60 healthy controls. The cancer patients were grouped according to tumor stage. Serum levels of IgG, IgA and IgM were determined in the preoperative period. The results show a significant decrease in IgG titers in all stages of gastric cancer but more so in the initial stages of development. In the cases of cancer of the colon, the IgG reduction was most evident in the advanced stages of disease. IgA levels were significantly elevated in stage III of gastric cancer and all stages of cancer of the large intestine. IgM levels in gastric cancer behave in a similar manner as IgA, and is elevated in the final stages of cancer of the colon.

Adenocarcinoma↗