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J M Lauritsen

Publications and source records attributed to J M Lauritsen.

18 recordsLinked to original sources
PubMed2001

Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis.

BACKGROUND: Atopic diseases are common in children and adolescents. However, epidemiological knowledge is sparse for hand eczema and allergic contact dermatitis in this age group. Furthermore, no population-based studies have evaluated the prevalence of atopic diseases and hand and contact dermatitis in the same group of adolescents. OBJECTIVES: To assess prevalence measures of atopic dermatitis (AD), asthma, allergic rhinitis and hand and contact dermatitis in adolescents in Odense municipality, Denmark. METHODS: The study was carried out as a cross-sectional study among 1501 eighth grade school children (age 12-16 years) and included questionnaire, interview, clinical examination and patch testing. RESULTS: The lifetime prevalence of AD was 21.3% (girls 25.7% vs. boys 17.0%, P < 0.001) using predefined questionnaire criteria. The 1-year period prevalence of AD was 6.7% and the point prevalence 3.6% (Hanifin and Rajka criteria). In the interview the lifetime prevalence of inhalant allergy was estimated as 17.7% (6.9% allergic asthma, 15.7% allergic rhinitis). The lifetime prevalence of hand eczema based on the questionnaire was 9.2%, the 1-year period prevalence was 7.3% and the point prevalence 3.2%, with a significant predominance in girls. A significant association was found both between AD and inhalant allergy, and between AD and hand eczema using lifetime prevalence measures. The point prevalence of contact allergy was 15.2% (girls 19.4% vs. boys 10.3%, P < 0.001), and present or past allergic contact dermatitis was found in 7.2% (girls 11.3% vs. boys 2.5%). Contact allergy was most common to nickel (8.6%) and fragrance mix (1.8%). CONCLUSIONS: High prevalence figures were found for atopic diseases, hand eczema and allergic contact dermatitis, and the diseases were closely associated. A considerable number of adolescents still suffers from AD, and a considerable sex difference was noted for hand eczema and allergic contact dermatitis. Nickel allergy and perfume allergy were the major contact allergies. In the future this cohort of eighth grade school children will be followed up with regard to the course and development of atopic diseases, hand eczema and contact dermatitis.

Adolescent↗
PubMed2000

Incidence of unintentional injuries in farming based on one year of weekly registration in Danish farms.

BACKGROUND: In Denmark, farming ranks as the industry with the highest incidence rate of fatal injuries. For nonfatal injuries, insufficient registration practices prevent valid comparisons between occupations. This study examines the occurrence of farm accidents and injuries, as well as work-specific factors, via weekly registration in a representative sample of 393 farms in one county during 1 year. METHODS: From a random sample of 794 farms, (10% of farms in the county of Ringkoebing, Denmark) 393 farms with 1,597 residents and employees participated in a 1-year self-registration of work-related unintentional incidents. The procedure included a detailed registration of hours spent on all main working tasks. Weekly recording of incident occurrence or nonoccurrence resulted in the completion of 19,782 registration forms. Three months after incident occurrence, a telephone interview was conducted about the related work situation and resulting injuries. RESULTS: During the 12-month period, 479 occupational accidents were reported, of which 389 resulted in an injury. The absolute number of injuries increased with number of work hours, but there was no relative increase of incidence by work hours. Persons below the age of 50 had slightly less than a doubled risk compared with those over 50 years of age. No other marked, reliable age effect was found. There was, however, a seasonal variation, with summer and autumn having a double relative incidence compared with winter and spring. Among farm owners, 35% experienced at least one injury per year, while this was the case for 17% of farm laborers. When adjusting for work hours, the increased frequency of injuries among farm owners was reduced to a factor of 1.5. Animal-related work was the most common injury mechanism. Repair and maintenance work was found to be the most dangerous task relative to the number of task-specific work hours. Subgroups of tasks with a markedly increased injury rate were moving animals within the farm, veterinary procedures, and repair of field machinery and stable equipment. CONCLUSIONS: Farm injuries occur among 32% of full-time farmers and farm laborers each year. A quarter of these require professional treatment. This area calls for preventive action.

Accidents, Occupational↗
PubMed1999

[Agricultural occupational accidents in the county of Ringkoebing. Local registration].

The aim of the study was to obtain knowledge of accidents and working conditions related to farm accidents for purposes of a preventive intervention. The survey was a prospective study following a cohort of 393 farms in the county of Ringkoebing in West-Jutland, Denmark. Every farm in the study registered work activity and farmwork related incidents that required a break in work. Every farm reporting an incident was interviewed by phone. The owner himself and the part-time farmer had the highest injury rate per working hour. There was no difference between animal and field related work looking at the incidence rate per workhour, but the incidence rate whilst repairing machinery and buildings was five times higher and highly significant. The results indicate the existence of groups and areas of risk, where a preventive effort is needed. The study is followed by a randomised intervention study among 200 Danish farms.

Accidents↗
PubMed1999

[Occupational hand injuries. A population-based description of the incidence and referral to casualty departments].

The overall incidence of self-reported occupational hand injuries in a Danish population was estimated to 4.7%, with the highest incidence among the youngest, men and employees in the production and building industries. The life-time risk were 93% for men and 73% for women. Age and gender were found to be independent risk factors for the occupational hand injuries. The proportion treated in the casualty department was 0.28, for injuries with disability and time off work the proportions were 0.46 and 0.69 respectively. No age, gender or occupation specific selection for attending the hospital was found. Prevention-trials against hand injuries should therefore have a high priority, and it is recommended that hospital data files are used increasingly in future prevention programs.

Accidents, Occupational↗
PubMed1999

[Development of post-traumatic stress following severe work-related accidents].

The diagnostic criteria for posttraumatic stress disorder (PTSD) employed by the American DSM-IV from 1994 and ICD-10 from 1993 are reviewed. The literature concerning PTSD, with particular focus on PTSD in relation to occupational accidents, is discussed. A single epidemiological study of the occurrence of PTSD following serious nonfatal occupational accidents reports a one to two years prevalence of PTSD of 4.3%. Physicians and safety and health organisations within companies should be aware of the potential for the occurrence of acute and chronic stress conditions following occupational accidents, primarily with respect to providing supportive psychological treatment and social support aimed at preventing the development of chronic symptoms.

Accidents, Occupational↗
PubMed1999

[Post-traumatic stress after occupational accidents].

This study focuses on post-traumatic stress disorder in a follow up one to two years after the occupational accident. The aim was to estimate the prevalence of PTSD, changes in general health status and issues of compensation. The material was all serious accidents registered in the Danish National Register of Work Accidents during 1991. Seriousness was defined by type of injury, including all cases of amputations, bone fractures and extensive body lesions. Of 4745 possible, 3663 persons (77%) participated in a questionnaire study. The prevalence fulfilling the complete set of criteria of posttraumatic stress disorder as a chronic state was 2.8% (102 persons), of whom half had been given compensation. Among the most severe accidents the prevalence was 7.6%. In conclusion, in a large cohort of persons with moderate and severe occupational injuries this study demonstrated that post-traumatic stress disorder and lasting psychological distress should be a matter for concern in addition to the physical injury.

Accidents, Occupational↗
PubMed1999

Manganese exposure in foundry furnacemen and scrap recycling workers.

OBJECTIVES: Cast iron products are alloyed with small quantities of manganese, and foundry furnacemen are potentially exposed to manganese during tapping and handling of smelts. Manganese is a neurotoxic substance that accumulates in the central nervous system, where it may cause a neurological disorder that bears many similarities to Parkinson's disease. The aim of the study was to investigate the sources and levels of manganese exposure in foundry furnacemen by a combined measuring of blood-manganese (B-Mn) and manganese in ambient air (air-Mn). METHODS: During a period of 16 months, Air-Mn and B-Mn (denoted 'exposure values') were measured involving 24 furnacemen employed in three small size foundries and 21 scrap recycling workers from one plant. In the study period, 18 furnacemen had B-Mn measured 3-4 weeks after decreasing or stopping exposure (denoted 'post-exposure values'). The reference group for the B-Mn measurements consisted of 90 Danish male subjects. RESULTS: Furnacemen who work in insufficiently ventilated smelting departments inhale, absorb, and retain significant amounts of manganese in their blood (approx. 2.5-5 microg/l above reference values) despite a generally low measured airborne level of manganese fumes (0.002-0.064 mg/m(3)). The 'exposure values' compared with 'post-exposure values' revealed a significant decrease in the B-Mn (on average 3.7 microg/l) level of the most exposed furnacemen. Two persons in our study were suspected of suffering clinically subacute manganese intoxication as both had B-Mn levels beyond the normal limit (25 and 29 microg/l, respectively). The potential problem disappeared completely after cessation of exposure, and the B-Mn levels decreased to 9.4 and 14.1 microg/l, respectively. CONCLUSIONS: Risk assessment based on combined measurements of B-Mn and air-Mn seems to be valid in the interpretation of workers' hazard. Our study indicates that B-Mn may be a valuable parameter for estimating recent exposure (within 1-2 weeks). However, more knowledge is needed about the B-Mn level and its relation to neurological symptoms.

Adult↗
PubMed1999

Helicobacter pylori and risk of ulcer bleeding among users of nonsteroidal anti-inflammatory drugs: a case-control study.

BACKGROUND & AIMS: Peptic ulcer complications related to use of nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common serious adverse drug reactions. Whether Helicobacter pylori infection potentiates this gastrointestinal toxicity of NSAIDs is still unresolved. In this study, we investigated the role of H. pylori as a cause of bleeding peptic ulcer among NSAID users. METHODS: A case-control study of current users (n = 132) of NSAIDs (including acetylsalicylic acid), admitted because of bleeding peptic ulcer, was performed. Controls were 136 NSAID users without gastrointestinal complications. H. pylori was diagnosed by either increased levels of serum immunoglobulin G or by 13C-urea breath test. RESULTS: Fifty-eight (44%) case subjects had a bleeding gastric ulcer, 54 (41%) had a bleeding duodenal ulcer, 12 (9%) had both gastric and duodenal ulcers, and 8 (6%) had hemorrhagic gastritis. H. pylori was present in 75 (57%) cases compared with 59 (43%) controls. The adjusted odds ratio of bleeding peptic ulcer among NSAID users associated with H. pylori infection was 1.81 (95% confidence interval, 1.02-3.21). H. pylori accounted for approximately 24% of bleeding peptic ulcers among elderly NSAID users. CONCLUSIONS: NSAID users infected with H. pylori have an almost twofold increased risk of bleeding peptic ulcer compared with NSAID users without H. pylori.

Adult↗
PubMed1999

Time off work after occupational hand injuries.

This study analysed the impact of several factors on the start and duration of time off work among 802 patients with occupational hand injuries, in order to identify prognostic indicators. The study showed that external factors such as work and social condition seemed to have less influence on time off work than expected, whereas advice from doctors, flashbacks and impairment symptoms were important determinants.

Attitude to Health↗
PubMed1998

[Trade-specific occurrence of occupational hand injuries].

The purpose of the investigation was to estimate the trade-specific incidence of occupational hand injuries, to estimate the trade-specific cumulative incidence proportion and to investigate whether age, gender and trade each were independent risk-indicators for occupational hand injuries. In a retrospective design, 823 patients with occupational hand injuries treated at Odense University Hospital were included in the investigation. The population at risk was 96,512 persons engaged in active employment within the municipality of Odense. The overall incidence of occupational hand injuries was estimated to 1.7 percent and 0.3 percent for significant injuries. The incidences in the production- and building industries were significantly higher than the incidence in the service industries. Gender and occupation were both found to be independent risk-indicators for occupational hand injuries, age only for the minor injuries. Occupational hand injuries seem to be so common, that prevention-trials should continuously be intensified. The target-groups should firstly be employees in the production industries, however prevention-trials directed against specific age- and gender behaviour patterns should also be considered.

Accidents, Occupational↗
PubMed1997

[NSAID and ulcer complications. An analysis of risk factors].

Use of NSAIDs is recognized as an important cause of peptic ulcer complications. The aim of this nested case-control study was to identify risk factors for NSAID-related ulcer complications. Cases were consecutive NSAID users admitted with an ulcer complication (n = 94), and controls were a random sample of all NSAID users without ulcer complication identified by a pharmaco-epidemiological database (n = 324). Risk factors for patients at start of NSAID-therapy were: high age: 60-75 yr; Odds Ratio (OR) 3.5 (95% CI: 1.8-7.0); > 75 yr: OR 8.8 (4.3-18.1); male sex: OR 1.7 (1.0-3.0); ulcer history: OR 2.5 (1.2-5.1); steroid treatment: OR 2.0 (0.8-4.6); smoking: OR 1.6 (0.9-2.7); alcohol use: OR 1.8 (0.9-3.6). Risk factors for patients on NSAID-therapy were: high age, male sex, ulcer history, and smoking, and furthermore dyspepsia: OR 2.1 (1.0-4.2), especially NSAID-related dyspepsia: OR 8.9 (4.1-19.2). Risk was lower for patients treated more than three months. In conclusion, risk measured from this design can be shown to correlate strongly with the rate difference, a measure that is more clinically relevant than conventional relative risk estimates. Strong risk factors for NSAID-related ulcer complication are high age, male sex, ulcer history, and dyspepsia related to the NSAID therapy.

Adult↗
PubMed1997

Why has the search for causes of low back pain largely been nonconclusive?

STUDY DESIGN: Cross-sectional data were collected in a postal questionnaire within the framework of a 5-year randomized, controlled, prospective, population-based study. OBJECTIVES: To investigate to what extent associations differ or concur when correlates of low back pain are rested against various subdefinitions of low back pain. SUMMARY OF BACKGROUND DATA: Numerous factors have been suspected to cause low back pain, but findings have not been constantly reproduced in epidemiologic studies. METHODS: Data were collected on 748 people reporting nonspecific low back pain some time during the year preceding the survey. Six correlates of low back pain (age, sex, marital status, attitude to a healthy life-style, self-reported physical activity at work, and smoking) were cross-tabulated against nonspecific low back pain and against four subgroups of low back pain. RESULTS: There was only one statistically significant strong association between the potential risk indicators and the nonspecific definition of low back pain, but several emerged when the low back pain group was split into subgroups. Different subgroups of low back pain did, indeed, relate differently to the various correlates. CONCLUSIONS: It is necessary to define some clinically relevant subgroups of low back pain to accelerate the search for causal mechanisms.

Adult↗
PubMed1996

Cancer incidence among mild steel and stainless steel welders and other metal workers.

The cancer incidence in a historical cohort of 10,059 metal workers employed during the period 1964-1984 was investigated. Standardized incidence ratios (SIR) were calculated based on registry extracts from the Danish Cancer registry. Lifetime exposure data (occupational and other) were obtained by a postal questionnaire in living cohort members and interviews by proxy for deceased and emigrated subjects. The incidence of lung cancer was increased among workers ever "employed as welders" (SIR = 1.38, 95% C.I. 1.03-1.81). There was a significant excess risk of lung cancer among "mild steel (MS) only welders" (SIR = 1.61, 95% C.I. 1.07-2.33) and "nonwelders" (SIR = 1.69, 95% C.I. 1.23-2.26) (indicating carcinogenic exposures other than welding), a borderline significant lung cancer excess among "MS ever welders" (SIR = 1.32, 95% C.I. 0.97-1.76), and a nonsignificant excess risk of lung cancer among "stainless steel (SS) only welders" (SIR = 2.38, 95% C.I. 0.77-5.55). In spite of signs of inconsistency in the risk estimation by duration and latency, we find the results support the conclusions of other studies: employment as a welder is associated with an increased lung cancer risk.

Asbestos↗
PubMed1996

Lung cancer mortality in stainless steel and mild steel welders: a nested case-referent study.

The association between welding and lung cancer has been studied in a nested case-referent study within a cohort of 8,372 metal workers. Lifetime exposure data on welding and other occupational exposures, as well as alcohol and smoking habits, were obtained by interviews of spouses and colleagues. Analysis was based on 439 deceased referents and 94 deceased cases. There was a 70% excess of lung cancer associated with "welding exposure ever" (OR +/- 95% C.I.: 1.68, 1.02-2.78). Overall OR for "mild steel (MS) welding ever" was 1.64, 0.99-2.72. The risk estimates for welding exposures showed an increasing tendency up to 15 years of exposure. The pattern of stainless steel (SS) welding resembles that of mild steel with an estimated OR of 1.65, 0.88-3.0. The general conclusion is that MS welding as well as SS welding seems to be associated with an increased risk of lung cancer. Further followup of the cohort will enhance precision of the estimates.

Alcohol Drinking↗
PubMed1996

Non-steroidal anti-inflammatory drugs and ulcer complications: a risk factor analysis for clinical decision-making.

BACKGROUND: Use of non-steroidal anti-inflammatory drugs (NSAIDs) is recognized as an important cause of peptic ulcer complications. The aim of this nested case-control study was to identify risk factors for NSAID-related ulcer complications. METHODS: Cases were consecutive NSAID users admitted with an ulcer complication (n = 118), and controls were a random sample of all NSAID users without ulcer complication identified by a pharmacoepidemiologic database (n = 540). RESULTS: Ninety-four of 118 cases were interviewed, and 324 of 540 controls answered the questionnaire. Analysis showed no difference between included and non-included subjects. Risk factors for patients at start of NSAID therapy were high age: 60-75 years (odds ratio (OR), 3.5 (95% confidence interval (Cl), 1.8-7.1); > 75 years (OR, 8.9 (4.3-18.3)); male sex (OR 1.7 (1.0-3.0)); ulcer history (OR 2.5 (1.2-5.1)); steroid treatment (OR 2.0 (0.8-4.6)); smoking (OR 1.6 (0.9-2.7)); and alcohol use (OR 1.8 (0.9-3.6)). Risk factors for patients receiving NSAID therapy were high age, male sex, ulcer history, smoking and, furthermore, dyspepsia (OR 2.0 (1.0-4.2)), especially NSAID-related dyspepsia (OR 8.7 (4.0-18.9)). Risk was lower for patients treated more than 3 months. CONCLUSION: Risk measured from this design can be shown to correlate strongly with the rate difference, a measure that is more clinically relevant than conventional relative risk estimates. Strong risk factors for NSAID-related ulcer complication are high age, male sex, ulcer history, and dyspepsia related to the NSAID therapy. Avoiding NSAID therapy in these high-risk patients, whenever possible, might prevent many adverse events.

Adult↗
PubMed1995

The prevalence of low back pain in the literature. A structured review of 26 Nordic studies from 1954 to 1993.

STUDY DESIGN: A systematic review was done for all prevalence studies on low back pain in the Nordic population between 1954 and 1992 that could be identified. OBJECTIVE: To investigate the homogeneity of data. SUMMARY OF BACKGROUND DATA: Costs resulting from low back pain are steadily increasing, but it is not known whether this has been caused by changes in healthcare behavior or whether there is an underlying increase in the occurrence of low back pain in the general population. The prevalence rate of low back pain has been continually estimated over the last 40 years, but are the studies sufficiently homogeneous to allow pooling of data? METHODS: Twenty-six population-based epidemiologic surveys on the occurrence of low back pain in the Nordic countries were assessed for the following criteria: quality of the report according to a checklist related to the representativeness of the study sample, quality of data, and definition of low back pain; study design (study population, definition of low back pain, and recall periods); probability of data, taking into account the quality of the report, the definition of low back pain, type of population, age, and sex. RESULTS: Only 10 studies fulfilled a minimum of 75% of the methodologic criteria. There were large differences between studies regarding study design, and the poolability of data was limited to a few studies, none of which fulfilled all of the above criteria. CONCLUSION: A more stringent, systematic, and uniform methodologic approach to studying the prevalence (or incidence) of back pain is needed.

Adolescent↗
PubMed1994

[Epidemiology of acute wrist injuries].

Epidemiological data on wrist injuries in a population can be used for planning by applying them to criteria of care and thus deriving estimates of needs for care according to currently desirable standards. In a one-year study all patients 15 years or older with acute wrist trauma and treated at the emergency room were examined according to an algorithm until a diagnosis was established. The overall incidence of wrist trauma was 69 per 10,000 inhabitants per year. Incidence of wrist trauma requiring radiographic examination was 58 per 10,000 per year. The incidence of fractures of the distal radius was 27 per 10,000 per year (males, 16 per 10,000, females, 37 per 10,000 per year). In order to evaluate the completeness (defined as the proportion of patients with wrist injuries seen at the emergency room out of all patients with wrist injuries in the catchment area) of the hospital based data an analysis was performed using data from a population based study. A completeness rate of 0.56 (95% confidence interval 0.31-0.78) was found. A radiographic examination had been performed in all patients reporting a fracture, justifying the use of fractures as an incidence measure when comparing groups of patients with a wrist trauma.

Acute Disease↗