The goal of this study was to determine the frequency and methods of intraoperative fetal and uterine monitoring during maternal surgery in the United States. Maternal surgery was defined as nonobstetric surgery during pregnancy that required general or regional anesthesia. We mailed a 21-item questionnaire to the perioperative nurse managers of US hospitals at which more than 2,000 babies are delivered annually (n = 579). Nearly 60% of responding hospitals routinely used some form of fetal monitoring during maternal surgery; more than 40% of responding hospitals did not use intraoperative fetal and uterine monitoring routinely during maternal surgery.

Chi-Square Distribution↗

PubMed1994

Perioperative care of the pregnant surgical patient.

Successful perioperative management of the pregnant surgical patient requires a multidisciplinary nursing approach to decrease perinatal morbidity and mortality. A comprehensive perioperative patient care plan and coordination with obstetric and neonatal team members enhance the surgical outcome for both the mother and her child.

Adult↗

PubMedDate not supplied

Open mitral commissurotomy during pregnancy. A case study.

Pregnancy increases cardiovascular stress and can cause an asymptomatic woman with mitral disease to become symptomatic. Correction of the mitral defect by open heart surgery may be necessary. In cases where open heart surgery is conducted, special nursing considerations for the pregnant woman and her fetus must be recognized to ensure optimum maternal and fetal outcome. Therefore, a multidisciplinary nursing approach is indicated. A case study and nursing care plan are presented.

Adult↗

PubMedDate not supplied

Maternal surgery.

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Female↗

PubMedDate not supplied

Pathological evaluation of WR-151327 administered orally in irradiated and non-irradiated male mice.

Studies were made on the radioprotective and toxic effects of orally administered WR-151327 in male CD2F1 mice. The lowest dose of orally administered drug permitting probit analysis of data was 450 mg per kg. The calculated radioprotective dose reduction factors (DRF) at 450 mg per kg and 900 mg per kg of body weight (BW) WR-151327 were 1.2 and 1.3, respectfully. Pathological examination at 8, 30 or 90 days post administration of 100, 450, or 900 mg per kg of the drug demonstrated that the major target organ for orally dosed mice was the testes. There was a decrease in the number of cells in the germinal cell layers of testes from animals administered 450 mg per kg WR-151327 or 10 Gy whole body irradiation after eight days. Moreover, there was a dramatic reduction in the germinal cells in mice seminiferous tubules treated with a combination of 450 mg per kg WR-151327 plus 10 Gy radiation after eight days.

Animals↗

PubMedDate not supplied

Fetal and uterine response during maternal surgery.

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Adult↗

PubMedDate not supplied

Comparative intestinal and testes toxicity of four aminothiols in irradiated and nonirradiated mice.

Intestinal and testicular toxicity in groups of nonirradiated and irradiated mice were investigated after intraperitoneal injection of aminothiol compounds or saline. Four aminothiols were studied. Three were prodrugs: WR-2721, WR-3689, and WR-151327 and one was the active form of WR-2721: WR-1065. Thirty minutes after injection, the mice were sham-irradiated or bilaterally exposed (whole body) to 60Co gamma-irradiation at a dose rate of 1 Gy per min to a total dose of 15 Gy. Four days after injection, mice were euthanised, and the intestines and testes were removed and histologically examined. The intestinal crypt cell number was increased in all the irradiated mice given WR-compounds compared to controls (P < 0.05). Interestingly, the crypt cell number in nonirradiated mice given WR-1065 was also greater than control or WR-2721 (P < 0.05) treated mice. Germinal cell numbers from testes of mice administered aminothiols prior to radiation decreased or did not change. Some swelling of the seminiferous tubules was also observed. The germinal cell numbers in sham-irradiated mice were also less than the controls. Thus, aminothiol addition can provide limited protection to intestinal crypt cells but not to germinal cells of the testes in response to gamma-irradiation. There is also evidence that aminothiols are toxic to the germinal cell layer of the seminiferous tubules when given to sham-irradiated mice.

Amifostine↗