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Biomedical subjects

J M Kelly

Publications and source records attributed to J M Kelly.

At least 199 records · Page 11Linked to original sources
PubMed1976

Early experience with the Boerema button for bleeding oesophageal varices.

Early experience with the use of the Boerema button for bleeding oesophageal varices is reported. A simplified technique for its insertion is described, and of the 6 patients so treated, only 1 died. No patient has re-bled in the short follow-up period available, and oesophageal appearances suggest that prolonged relief from bleeding can be anticipated. Further exploration of the button ligation transection technique is suggested not only for control of acute bleeding, but also for patients unsuitable for shunt surgery.

Aged↗
PubMed1976

Reconstruction of the oral cavity after obliterative surgery for cancer.

Simple and reliable methods for reconstruction of the oral cavity after obliterative surgery for carcinoma include (1) nasolabial cheek flaps, (2) hemiforehead and total forehead flaps, and (3) temporal island flaps. In general, the nasolabial flap is sufficient for resurfacing areas of the oral cavity anterior to the second molar tooth, while the temporal island flap provides satisfactory coverage posterior to this area. The forehead flap, which is very durable and reliable, is reserved for reconstruction of the more massive defects. Technics and use of each reconstructive procedure are described.

Face↗
PubMed1976

Ultrastructure of mumps virus replication in organotypic cultures of hamster choroid plexus.

Organotypic cultures of newborn hamster choroid plexus were inoculated with equal titre doses of newly isolated or hamster adapted strains of mumps virus. The ultrastructure of virus replication in choroid epithelial cells of the cultures was compared. No qualitative differences were observed; however, the adapted strain produced significantly greater numbers of virions and earlier destruction of the cultures. These findings are consistent with previous in vivo observations of the ultrastructure of the replication of these strains in the newborn hamster central nervous system. This in vitro study leads further support to the hypothesis that differences in the in vivo biological effects of the virus strains are primarily the result of virus-cell rather than virus-host interactions.

Animals↗
PubMed1975

Myelination inhibiting and neuroelectric blocking factors in experimental allergic encephalomyelitis.

Sensitization of Lewis rats with whole central nervous system tissue or with purified myelin induced both experimental allergic encephalomyelitis (EAE) and a serum factor which inhibited myelin formation in vitro. Sensitization with the encephalitogenic factor, myelin basic protein, induced EAE, but not the myelination inhibition factor. Sensitization with cerebroside induced neither EAE nor myelination inhibition factor. The serums from control animals without EAE as well as from animals sensitized with all of the above antigens blocked evoked electrical responses in vitro.

Animals↗
PubMed1975

Neuropathologic effects of intrathecal water.

In attempting to control the pain of disseminated carcinoma, a variety of agents has been injected intrathecally. This report deals with the neuropathologic changes in spinal roots and spinal cord of four patients into whose lumbar sacs 100 to 285 ml of distilled water was infused. Survival following the procedure ranged from 9 to 50 days. In most severely affected case (285 ml instilled 50 days prior to death) the abnormalities were: (1) severe breakdown of axons and myelin sheaths of the lower cauda equina and to a lesser extent of other roots at levels as high as the eighth cervical segment, (2) severe central chromatolysis of anterior horn cells in lumbo-sacral spinal cord with milder degrees of change in the thoracic and lower cervical spinal cord, and (3) striking vacuolar change and axonal swelling, primarily in the lateral columns ascending as high as the lower cervical spinal cord. A second case (140 ml instilled 24 days prior to death) showed similar but milder changes. The remaining cases (100 ml instilled 34 days prior to death: 100 and 200 ml instilled 27 and 9 days prior to death) showed no changes referable to intrathecal water. Infusion of distilled water intrathecally is capable of producing distinctive lesions of spinal root and cord.

Adenocarcinoma↗
PubMed1975

The body composition of a college football team.

The body composition and anthropometric measurements of 65 college football players were studied. Body composition was determined by underwater weighing with an accurate assessment of residual volume. The anthropometric measurements included height, weight, seven skinfolds, waist circumference and wrist diameter. A step-wise multiple regression analysis of the data indicated that body density and body fat could be predicted from anthropometric measurements. A multiple correlation of .96 was found between body density and three independent variables (waist circumference, triceps skinfold and height). The derived regression equations' standard errors of the estimate were 0.0041 body density units and 1.64 percent fat respectively. The team data were divided into five categories by position. When subjected to analysis of variance, significant differences at the .01 level of confidence suggested that at least two separate groups, backs and linemen, be used in future body composition studies of football teams. The estimated optimal playing weights of each player were determined by densitometry, and each player and the coach estimated that their optimal weights through personal experience. It was found that the players and the coach estimated the players optimal mean weight by 9 and 6 pounds heavier, respectively, than the densitometric analysis indicated as optimal.

Adolescent↗
PubMed1972

Vagotomy for gastric ulcer.

Out of a series of 75 patients who were treated by vagotomy and drainage for gastric ulcer 66 have been followed up for one to seven years (average three-and-a-half years). Four recurrent gastric ulcers occurred among the 33 cases of ulcer of the lesser curve or body with no antral or duodenal lesion (type I). Among the 42 patients with an antral ulcer or an associated active or healed pyloric or duodenal lesion (type II or III) there was only one recurrence. The recurrence rate for men was 5% and for women 12%. One patient died two years after operation from cancer which may have originated in the stomach. The clinical results in patients without recurrences were generally satisfactory.Vagotomy, preferably selective, with drainage is a satisfactory operation in gastric ulcers of types II and III. For ulcers of type I, gastrectomy is to be preferred except in selected cases.

Adult↗