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Biomedical subjects

J M Joyce

Publications and source records attributed to J M Joyce.

23 records · Page 2Linked to original sources
PubMed1986

Disuse osteoporosis: mimic of neoplastic disease.

Disuse osteoporosis, a common sequela to immobilization, consists of bony changes that may mimic neoplastic disease. This paper describes the different types of cortical and medullary demineralization that can be manifested radiologically and the histopathologic basis for these alterations. Six cases are included that exemplify these changes, and comparison is made with multiple myeloma.

Aged↗
PubMed1986

Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas.

DNA fragments from a locus spanning 29 kilobases within chromosome band 13q14 detected deletions in 3 retinoblastomas out of 37 such tumors examined. Somatically occurring, homozygous deletions spanning at least 25 kilobases were detected in retinoblastomas from two unrelated patients. These deletions are bounded by the esterase D locus proximally. In a third patient, both tumor cells and leukocytes have a deletion of one chromosome 13 homolog, with one end of the deletion localized to a 1.55-kilobase fragment within the cloned region. It is likely that the cloned locus is within a few hundred kilobases of the retinoblastoma gene (i.e., the locus governing predisposition to such tumors) and that the deletions detected also involve the retinoblastoma gene. Further, it may be possible to base a successful approach to the isolation of the retinoblastoma gene on this assumed physical proximity of the two loci.

Chromosome Deletion↗