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Biomedical subjects

J M Holbert

Publications and source records attributed to J M Holbert.

29 records · Page 2Linked to original sources
PubMed1987

The postlobectomy chest: anatomic considerations.

The authors present a systematic review of the changes that occur in pulmonary and extrapulmonary anatomy as the result of lobar collapse or resection. Differences in the changes produced by lobectomy and lobar collapse are noted.

Humans↗
PubMed1987

CT of interpectoral lymph nodes.

The presence of lymph nodes between the pectoralis major and minor muscles (Rotter's nodes) has been noted in the anatomic and surgical literature. We analyzed the appearance of the interpectoral space and nodes on chest CT scans of 25 patients without known chest wall abnormalities or causes for lymphadenopathy. In some of these cases small structures were detected in the interpectoral fat that could be either vessels or nodes. In addition we studied chest CT scans in six patients with interpectoral adenopathy due to metastases from breast cancer. The nodes were oval soft-tissue densities ranging from 1.5 X 1 cm to 3.5 X 3 cm in diameter.

Breast Neoplasms↗
PubMed1986

Hepatosplenic fungal infection: CT and pathologic evaluation after treatment with liposomal amphotericin B.

Disseminated fungal disease, predominantly involving liver and spleen, developed in eight patients with hematologic malignancies. Because the patients failed to respond to standard antifungal drugs, they were treated with liposomal amphotericin B (L AmpB). Before therapy began, the diagnosis was confirmed histologically and the patients underwent abdominal computed tomography (CT), which indicated hepatosplenomegaly with or without multiple microabscesses in the liver and spleen. After each course of treatment with L AmpB, patients underwent CT, followed by either open or CT-guided percutaneous aspiration biopsy of the liver. Post-treatment CT showed partial regression of lesions in six patients and persistence in two. In all patients a liver biopsy confirmed that the lesions noted after treatment were due to granulomas or focal areas of fibrosis compatible with healing. Thus, the persistence of multiple defects on enhanced scans in two patients was not an indication of persistent abscesses. Clinical response was an additional important factor. Close clinical and pathologic correlation in addition to CT scanning are required in the follow-up of hepatosplenic fungal infections.

Adolescent↗
PubMed1985

CT evaluation of the pelvis after hemipelvectomy.

From examination of 69 pelvic CT scans from 25 patients, the role of CT after hemipelvectomy is examined. A brief description of the various types of hemipelvectomy, including simple, extended, compound, and modified, is presented. The new variants of internal and modified internal hemipelvectomy are also included. The normal post-surgical changes in the musculoskeletal structures and pelvic viscera are described and illustrated. Postoperative abnormalities detected included hematoma, inflammatory changes, incisional hernia, ureteral obstruction, adenopathy, and local recurrence. An example of the usefulness of CT in CT-guided biopsy and CT-guided thermocouple placement is provided. CT of the pelvis is advocated as the method of choice to follow these patients, because of its ability to detect postoperative recurrence and complications.

Adolescent↗
PubMed1983

Diploid-triploid mosaicism: delineation of the syndrome.

Two unrelated infants with multiple anomalies and diploid-triploid mosaicism are reported. A comparison of their clinical features with those of twelve published reports with 2n/3n karyotype is provided. The data reveal that 2n/3n mosaicism is a clinically recognizable syndrome.

Abnormalities, Multiple↗
PubMed1981

BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure.

The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

Animals↗
PubMed1981

Abnormal immunologic measurements in asthmatic children and adults.

Several immunologic measurements were evaluated in 128 asthmatic patients (81 pediatric and 47 adults) in an effort to examine the question of altered cell-mediated immunity in asthmatics. Both pediatric and adult patients showed alterations in some but not all measurements. The results indicate that there are differences among subgroups of asthmatics and in some cases between pediatric and adult patients.

Adolescent↗