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Biomedical subjects

J M Hamilton

Publications and source records attributed to J M Hamilton.

At least 109 records · Page 6Linked to original sources
PubMed1975

Hormonally induced renal neoplasia in the male Syrian hamster and the inhibitory effect of 2-bromo-alpha-ergocryptine methanesulfonate.

One group of male Syrian hamsters received diethylstilbestrol (DES) over a period of 9 months. All developed widespread and severe renal tumors. Another group of male Syrian hamsters was given DES plus 2-bromo-alpha-ergocryptine methanesulfonate (CB154) over the same period. These hamsters either did not develop renal tumors or had renal tumors that were minimal in severity. DES treatment induced hyperplastic and neoplastic changes in the intermediate lobe of the pituitary glands of treated animals, increased the number of prolactin-secreting cells, and decreased the number of somatotrophin-secreting cells. Adding CB154 significantly inhibited those changes in the pituitary gland. Histopathologic and ultrastructural examinations indicated that the renal tumors were carcinomas originating from proximal convoluted tubules.

Animals↗
PubMed1973

The combined effect of radiation and chemical carcinogens in female A X IF mice.

Groups of mice were exposed to various doses of ionizing radiation on one occasion. In two groups of animals the bladder carcinogens dibutylnitrosamine (DBNA) and 4-ethylsulphonyl-naphthalene-1-sulphonamide (ENS) were administered 48 hours after irradiation.Post mortem and histopathological examinations failed to show any significant lesion in the bladder of animals subjected to radiation per se. Furthermore, radiation did not influence the latent period or incidence of bladder tumours induced by DBNA and ENS. However, radiation shortened the latent period of mammary tumours and, in some groups, increased the incidence of such lesions. When radiation was combined with the chemical carcinogens there was a marked reduction in the incidence of mammary tumours.

Animals↗