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Biomedical subjects

J M Gupta

Publications and source records attributed to J M Gupta.

At least 37 records · Page 2Linked to original sources

Very low birthweight infants: a follow-up study.

This study was undertaken to determine the outcome of infants delivered at the Royal Hospital for Women during the years 1971 to 1975 who weighed 1500 g or less at birth and who survived the first 28 days of life. Of the 104 neonatal survivors, 79 were seen by one of the writers, nine were seen by other medical practitioners, four had died after the neonatal period, the parents of two children could not be induced to bring their child to be examined, and the remaining ten could not be traced. Abnormalities were found in 15 of the 88 children examined. Three had major physical handicaps (problems causing a restriction of normal lifestyle), 11 had minor handicaps (problems which did not restrict normal lifestyle), and eight had evidence of developmental delay. Infants who were small for gestational age tended to be below the 10th percentile for height or weight at follow-up more often than infants of the appropriate weight for gestational age.

Australia↗

Gastric shake test and pharyngeal lecithin/sphingomyelin ratios in new born infants.

Gastric shake test and pharyngeal lecithin/sphingomyelin ratios were measured in newborn infants with respiratory difficulties, and in low birth weight infants in the immediate neonatal period. Both tests were useful in distinguishing infants with idioathic respiratory distress syndrome from those with respiratory difficulty due to other causes. However, in six infants with idiopathic respiratory distress syndrome, the pharyngeal lecithin/sphingomyelin ratio indicated mature lungs, and in three of these, the gastric shake test showed the presence of surfactant. Five of these six infants had been delivered by emergency lower segment caesarean section because of maternal complications, which might account for the discrepancy between the laboratory results and the clinical condition of the patient.

Cesarean Section↗

Neonatal jaundice.

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Exchange Transfusion, Whole Blood↗

Present prognosis in neonatal meningitis.

A retrospective study of neonatal meningitis for a period of 6 years (1970 to 1975) is described. It was found that though the survival rate had increased since the introduction of the aminoglycosides, it was at the expense of major neurological sequelae in the survivors. It is suggested that breast feeding of all infants in the first few days of life will reduce the incidence of neonatatl meningitis. It is recommended that pooled human breast milk should not be heat-sterilized as this destroys anti-Escherichia coli immunoglobulin A.

Anti-Bacterial Agents↗

Intraventricular haemorrhage in the newborn.

Coagulation studies were performed on 128 babies who were premature or who had respiratory distress syndrome (RDS). Forty-four babies were found to have abnormal coagulation parameters. Twenty-one were treated with plasma coagulation factors II, VII, IX and X (PPSB), and of these six died from intraventricular haemorrhage (IVH). Twenty-two did not have PPSB treatment and four died from IVH. In 84 babies in whom coagulation studies gave normal results only one baby died from IVH. The combination of RDS and abnormal coagulation produced a high-risk group to IVH and treatment with PPSB did not reduce the incidence of IVH. It is postulated that prevention of IVH lies in early and effective treatment of RDS.

Blood Coagulation Disorders↗

A two year follow-up of infants with respiratory distress syndrome.

Forty-seven of 74 infants with idiopathic respiratory distress syndrome who had received intensive care in the neonatal period were examined between the ages of 15 and 24 months to assess their progress. All the children (including the premature infants) had caught up with their peers in height, weight and head circumference. Although 11 infants had a history of respiratory problems, only two showed residual lung changes on radiological examination. Only one infant who had frequent apnoeic spells had serious eye problems due to retrolental fibroplasia. A definite neurological deficit was found in one case, in which a congenital infection could not be ruled out.

Child Development↗