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Biomedical subjects

J M Greep

Publications and source records attributed to J M Greep.

At least 55 records · Page 3Linked to original sources
PubMed1980

Pseudomembranous colitis after whole gut irrigation with neomycin and erythromycin base.

An unprecedented fatal case of pseudomembranous colitis (PMC) is described, associated with the use of topical antibiotics (neomycin and erythromycin base) during whole gut irrigation. This case was one of a cluster of five, occurring within a period of 4 months in 1978. These observations tend to support the hypothesis that disturbances in bacterial flora give rise to PMC and furthermore that the short-term use of antibiotics does not prevent the occurrence of PMC.

Colon↗
PubMed1980

Prolongation of canine renal allograft survival. A study on the effect of donor pretreatment.

Treatment of kidney donors with procarbazine hydrochloride and methylprednisolone, respectively, 5 and 2 1/2 hr before harvesting the kidney, improved renal allograft survival in dogs significantly. Pretreatment of the donor did not have a deleterious effect on the early function of the kidney grafts. Donor blood transfused peroperatively into the recipient caused a significant reduction in survival of kidney grafts from pretreated donors, although it did not influence the survival of nontreated kidneys. Furthermore, it appeared that a peroperative injection of a suspension of nonirradiated donor lymphocytes as well as donor lymphocytes irradiated with 2,500 rad significantly decreased the survival time of pretreated kidneys. A peroperative transfusion of leukocyte-poor blood prepared with a leukocyte filtration column, which leaves erythrocytes, thrombocytes, and plasma and eliminates most of the leukocytes (99.9%), also abolished the effect of donor pretreatment. Thus, administration of donor blood constituents, whether lymphocytes or leukocyte-poor blood, can abrogate the beneficial effect of donor pretreatment on kidney graft survival. These data indicate that the effect of donor lymphocytes on the survival of pretreated kidneys is not because of a specific immunological activity of these lymphocytes but merely because of the presence of antigens on their cell surface.

Animals↗
PubMed1980

[Results of therapy combining peritoneal lavage and local application of antibiotics in 250 patients with acute perforating appendicitis].

Since 1967, 2480 appendectomies have been performed at the St. Lucas Hospital (Amsterdam) and the St. Annadal Hospital (Maastricht), of which 250 were for perforated appendicitis. A so-called 'combined method' of treatment was used in all these cases: during the operation saline was used to lavage the peritoneal cavity with the patients in the reverse-Trendelenburg position. Antibiotics were left in the peritoneal cavity. No intraperitoneal drainage was performed, but the wound was drained for 5 days. Postoperative treatment consisted of nasogastric suction and parenteral antibiotics for 5 days in combination with anticoagulation. With thus combined approach one death was seen in 250 cases. There were 20 cases of wound infection (8%), 7 pelvic abscesses (2.8%), and 2 retroperitoneal abscesses. No thromboembolic complications were seen because of the use of routine anticoagulation. For 191 patients (77%), total hospitalization was less than 14 days. This method of treatment is compared with recent reports in literature.

Acute Disease↗
PubMed1979

Adhesive capsulitis of the ankle (frozen ankle).

Adhesive capsulitis or "frozen ankle" is a syndrome resulting from repeated ankle sprains, or perhaps following immobilization after trauma. Ankle arthrography is a useful and safe diagnostic procedure in this syndrome. Typical arthrographic features are described together with case histories of two patients with frozen ankle. We suggest that early mobilization of the patient following trauma is particularly important in preventing the development of a forzen ankle syndrome.

Adult↗