A sex-linked enzyme in a reptile--association with a recent centric fusion in the common lizard.
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Biomedical subjects
Publications and source records attributed to J M Goux.
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Developmental variability in organisms underlies the relationship between ontogeny and phylogeny. The concept entropy permits a quantitative characterization of this variability and provides a basis for interpreting the phylogeny of heterochrony in evolution.
Two inhibitors of nucleotide metabolism, aminopterin and FUdR, were tested on a wild type strain, on two mutant strains: vg and vgnp, and on a vg strain with the wild type genetic background. Without inhibitors, a lengthening of the developing time was observed for the mutant strains compared to the wild type. With aminopterin, larval mortality and lengthening of developing time are significantly higher in the wild type than in the mutant strains. Mutant strains seemed to be resistant to low concentrations of FUdR. The hypothesis of a perturbed pyrimidine metabolism in the mutants seems to be confirmed.
On a theoretical model of cellular genome we demonstrate that the clonal multiplication induces an ineluctable decline of the "mitotic capacity". A cellular population is formed, the genomes of which include no more than one of each fundamental genetic element.
We define a theoretical model for clonal reproduction and we describe how the accumulation of mutations induces an ineluctable decline of the "mitotic capacity". During the vital cycle of organisms, meïosis and fecundation may have the function of making up for this fall. This should allow us to understand the temporal structure or the sexualisation of the vital cycle as well as some peculiarities of the spatial structure of the genome.
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If the period of time from zygotic to adult state is divided in successive intervals where the fitness of a particular genotype takes different values, a stable polymorphism can be maintained in the population, without any superiority of heterozygotes in any interval.
The intensity of penetrance of the vestigial gene in the progeny obtained by crossing a wild type and a vestigial strain characterizes the wild type.