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Biomedical subjects

J M Goux

Publications and source records attributed to J M Goux.

8 recordsLinked to original sources

[Ontogeny and phylogeny: a quantitative theory of heterochrony].

Developmental variability in organisms underlies the relationship between ontogeny and phylogeny. The concept entropy permits a quantitative characterization of this variability and provides a basis for interpreting the phylogeny of heterochrony in evolution.

Animals↗

[Study of the effect of 2 inhibitors of nucleotide synthesis, aminopterin and fluorodeoxyuridine, on wild type strains and vestigial mutants in Drosophila melanogaster].

Two inhibitors of nucleotide metabolism, aminopterin and FUdR, were tested on a wild type strain, on two mutant strains: vg and vgnp, and on a vg strain with the wild type genetic background. Without inhibitors, a lengthening of the developing time was observed for the mutant strains compared to the wild type. With aminopterin, larval mortality and lengthening of developing time are significantly higher in the wild type than in the mutant strains. Mutant strains seemed to be resistant to low concentrations of FUdR. The hypothesis of a perturbed pyrimidine metabolism in the mutants seems to be confirmed.

Aminopterin↗

[Clonal multiplication and mitotic capacity].

On a theoretical model of cellular genome we demonstrate that the clonal multiplication induces an ineluctable decline of the "mitotic capacity". A cellular population is formed, the genomes of which include no more than one of each fundamental genetic element.

Cell Division↗

[Vital cycle, mitotic capacity, and genomic restoration].

We define a theoretical model for clonal reproduction and we describe how the accumulation of mutations induces an ineluctable decline of the "mitotic capacity". During the vital cycle of organisms, meïosis and fecundation may have the function of making up for this fall. This should allow us to understand the temporal structure or the sexualisation of the vital cycle as well as some peculiarities of the spatial structure of the genome.

Clone Cells↗

[Endocyclic selection and stable polymorphism].

If the period of time from zygotic to adult state is divided in successive intervals where the fitness of a particular genotype takes different values, a stable polymorphism can be maintained in the population, without any superiority of heterozygotes in any interval.

Heterozygote↗