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Biomedical subjects

J M Gomez

Publications and source records attributed to J M Gomez.

At least 37 records · Page 2Linked to original sources
PubMed1996

Kaposi's sarcoma with an intense parasitization by Leishmania.

Visceral leishmaniasis has been reported as a complication in patients infected with human immunodeficiency virus (HIV) who live in areas where leishmaniasis is endemic or in patients who have traveled to these areas. Kaposi's sarcoma has been found frequently in patients with acquired immunodeficiency syndrome (AIDS). We report a HIV-infected patient having visceral leishmaniasis associated with Kaposi's sarcoma in which a biopsy specimen obtained from a pigmented cutaneous lesion revealed the coexistence of a Kaposi's sarcoma pattern with Leishmania parasitic colonization.

AIDS-Related Opportunistic Infections↗
PubMed1994

Salivary excretory pattern of testosterone in substitutive therapy with testosterone enanthate.

OBJECTIVE: To determine salivary and serum T levels by an RIA method after a single injection of 250 mg IM of commercially available T enanthate. DESIGN: Research study. SETTING: Patients attended in a hospital environment. PATIENTS: Sixteen men with secondary hypogonadism. INTERVENTIONS: Testosterone enanthate was administered, and salivary samples were taken before the injection. Thereafter, these samples were obtained daily until day 7 and then on alternate days until day 28 after injection. Blood samples were taken previously and after the injection (5 samples during the month). MAIN OUTCOME MEASURE: Salivary and serum T. RESULTS: Salivary T levels rose from 3.46 +/- 3.16 to 13.82 +/- 7.78 ng/100 mL (0.12 +/- 0.11 to 0.48 +/- 0.27 nmol/L) within 24 hours and remained in that range until day 7. From day 9, 7.20 +/- 2.88 ng/100 mL (0.25 +/- 0.10 nmol/L), a progressive decrease of these values was observed until day 14: 5.18 +/- 2.88 ng/100 mL (0.18 +/- 0.10 nmol/L). From day 16 until day 28, salivary concentrations returned to hypogonadal levels. CONCLUSION: We conclude that T salivary concentrations may be applied to assess the effectiveness of T substitutive therapy in hypogonadal men and could replace serum in the monitoring of this type of therapy.

Adult↗
PubMed1993

Sonographic diagnosis of pylephlebitis in children.

We present a case of inflammatory bowel disease in which the diagnosis of pylephlebitis was made by ultrasonography. The patient was treated with antibiotics and aspirin and had an uneventful recovery. The sonographic findings are described.

Child↗
PubMed1992

Survival prospects of extremely preterm infants: a 10-year experience in a single perinatal center.

During a 10-year period, 1977 to 1986, 233 (53%) of 442 inborn live births between 23 and 28 weeks' gestation survived; their 1-year survival rate was 7% at 23 weeks, 30% at 24 weeks, 31% at 25 weeks, 55% at 26 weeks, 67% at 27 weeks, and 71% at 28 weeks. No significant change in survival rate was observed over the years. Twelve percent of pregnancies and 20% of infants were multiple gestations. Singleton births had significantly higher survival rates compared with multiple births (58% versus 41%). The obstetric intervention rate, as measured by the frequency of cesarean section, increased significantly over the years: from 15% in 1977-1978 to 33% in 1985-1986. The neonatal intervention rate, as measured by the frequency of live births offered neonatal intensive care, remained unchanged. Ten percent were not treated: 4% had major malformations and 6% were considered "nonviable." Active perinatal management, which assumed fetal-neonatal viability, accounted for better survival rates compared with centers with a more passive management policy. Information on survival based on gestational cohorts plays an important role in helping obstetricians, neonatologists, and parents make appropriate management decisions.

Cesarean Section↗
PubMed1991

Duration of hospitalization in extremely preterm infants.

This study reports the age at hospital discharge of 233 survivors and age at death of 209 infants who were born at 23-28 weeks gestation over a 10 year period, 1977-86. The mean duration of hospitalization of survivors was 95 days and was inversely related to maturity at birth; those born at 23-25 weeks remained in hospital on average 1-2 weeks beyond term while those born at 26-28 weeks went home on average at term or 1 week before term. The mean age at death was 12 days: 53% within 1 day, 23% between 2 and 7 days, 15% between 8 and 28 days and 9% between 28 days and 1 year. The proportions of death in the post-neonatal period for infants born at 23-24 weeks, 25-26 weeks and 27-28 weeks were 2, 9 and 16% respectively. There was no significant trend in prolonged hospitalization of survivors or postponement of neonatal deaths to the post-neonatal period over the 1977-86 period. Nevertheless, both neonatal and post-neonatal mortality should continually be monitored in this extremely preterm group.

Gestational Age↗
PubMed1991

Thyroid stimulating antibodies in patients with Graves' ophthalmopathy.

The possible pathogenetic role of thyroid stimulating antibodies (TSAb) was studied in 24 patients. The TSAb were measured by their ability to stimulate concentration of cAMP in human thyroid slices incubated in vitro with the immunoglobulins of these patients. The patients were divided in two groups: Group I, 16 patients with eye disease and hyperthyroidism and Group II, eight patients with eye disease but without hyperthyroidism. TSAb, were found to be high in 15 patients of the Group I (3.22 +/- 1.74 pmol cAMP/mg of wet tissue, mean +/- S.E.M.) whilst were normal in six patients of the Group II (0.98 +/- 0.53 pmol cAMP/mg of wet tissue, mean S.E.M.) (p < 0.001). These findings indicate that TSAb is not a marker of the Graves' ophthalmopathy and support the concept that hyperthyroidism and exophthalmos are two separate disorders.

Adolescent↗
PubMed1984

[Familial mucosal neuromatosis: a minor form of the MEN-2b syndrome].

When the alert ophthalmologist found visible corneal nerves on a clear stroma, he must remind about the multiple endocrine neoplasia syndrome (M.E.N.-2b) and look for the medullary carcinoma of thyroid and the pheochromocytomas. Recognition of these ocular lesions as components of the syndrome is of the utmost importance because prompt identification of individuals affected by multiple endocrine neoplasia type 2 b facilitates early treatment of associated medullary thyroid carcinomas and pheochromocytomas. These endocrine neoplasias must be carefully searched by endocrine means. We present for the first time, in our knowledge, one family with M.E.N.-2b syndrome without endocrine neoplasias at this moment. We think it can be one minor presentation. We call this form "familial multiple mucosal neuromas".

Adolescent↗
PubMed1983

A family with adult spinal and bulbar muscular atrophy, X-linked inheritance and associated testicular failure.

A family with adult spinal and bulbar muscular atrophy with X-linked recessive inheritance (Kennedy's disease) is described. Affected members presented at age 20 with muscle cramps followed insidiously by gynaecomastia, partial loss of secondary sexual traits, loss of libido and inability to maintain an erection. Three had also testicular atrophy and severe oligospermia was found in two patients. Testicular biopsy in one case showed germinal failure with almost normal Leydig cells. Hormonal tests were suggestive of a primary testicular failure. Etiologic possibilities are considered.

Adult↗
PubMed1981

[Islet cell antibodies in diabetic patients with other autoimmune diseases (author's transl)].

The presence of antibodies directed against pancreatic islet cells was investigated in 18 insulin pendent diabetic patients with autoimmune disease (Group 1), in 8 insulin-independent diabetic patients with autoimmune disease (Group 2), in 42 non-diabetic patients with thyroid antibodies (Group 3), in 18 patients with antibodies against gastric parietal cells (Group 4) and in 100 healthy subjects (controls). Islet cell antibodies were found in 46% of group 1 patients and in only 1 patient of group 3 and 1 control. This would suggest the existence of a special form of autoimmune insulin-dependent diabetes characterized by a high incidence of islet cell antibodies and associated with other autoimmune diseases.

Autoantibodies↗
PubMed1976

[A new associated spondylarthritis: rheumatoid spondylarthritis].

The authors analyse 7 cases which presented the criteria of ankylosing spondylarthritis and HLA 27 positivity, together with those of defined or classical rheumatoid polyarthritis with positive results in the latex test and the Waaler-Rose reaction in the joint fluid and/or the serum. The sex distribution, 6 men and 1 woman, was the same as for that disease. The clinical manifestations were very variable, with a predominance of localized, peripheral oligoarthritis in the lower limbs. Repeated iritis occurred in three cases. Two presented subcutaneous nodules on the elbow. All cases showed bilateral sacroiliitis; syndesmophytosis was rare. The overall clinical picture indicated rather a combined spondylarthritis than pure spondylarthritis. It is suggested that the occurrence of spondylarthritis in a subject with the HLA 27 gene might modify the response to the etiological factors of rheumatoid arthritis. These cases may thus be considered as a new type of combined or secondary spondylarthritis.

Adolescent↗