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Biomedical subjects

J M Galloway

Publications and source records attributed to J M Galloway.

At least 37 records · Page 2Linked to original sources
PubMed1983

Increased respiratory chemosensitivity induced by oral almitrine in healthy man.

Cardiorespiratory effects of 50 mg and 100 mg doses of almitrine and placebo given orally on separate test days to twelve healthy volunteers were assessed in a double-blind crossover study. The drug caused no significant changes in ventilation, mixed venous CO2 tension, metabolic rate, heart rate or blood pressure while they were resting and breathing room air. With progressive hypercapnia, however, the ventilatory response increased by 5% after the 50 mg dose (NS) and by 27% after the 100 mg dose (P less than 0.05). There were greater increases in the response to progressive hypoxia by 78% after 50 mg of almitrine (P less than 0.01) and by 120% after 100 mg (P less than 0.01), which was also significantly greater than the increase after the 50 mg dose (P less than 0.01). In contrast there were only minor and inconsistent changes in chemosensitivity after administering placebo. The findings are consistent with an agonist action of almitrine in the peripheral chemoreceptors and suggest that it may have clinical value in managing respiratory failure due to hypoventilation.

Administration, Oral↗
PubMed1983

Increased respiratory chemosensitivity induced by infusing almitrine intravenously in healthy man.

The respiratory effects of intravenously infused almitrine were evaluated in healthy volunteers. In the dose range 0.25-1.0 mg/kg/hour it caused large and dose-dependent increases in hypoxic chemosensitivity, which were longlasting and more persistent than the drug's retention in the plasma. Increases in sensitivity to hypercapnia were much less and were detected only when the plasma almitrine exceeded 200 ng/ml. Small increases in resting ventilation and metabolic rate with a decrease in mixed venous carbon dioxide tension occurred only at the highest infusion rate. The findings accord with an action of almitrine in the peripheral chemoreceptors, which may be of therapeutic value in managing some cases of respiratory failure.

Adult↗
PubMed1980

Cystic adventitial disease of the popliteal artery.

A 62-year-old man with intermittent claudication but normal foot pulses at rest had no atheroma shown on femoral arteriography. There was evidence of external compression of the artery at the level of a popliteal cyst which was demonstrated by arthrography on films taken after sufficient exercise to be in communication with the knee joint. At operation the cyst was continuous with changes of cystic adventitial disease of the popliteal artery. Both the main cyst and th cystic changes in the artery were removed. Postoperatively the patient's claudication disappeared. Evidence is presented that synovial cysts play a part in the production of arterial cystic adventitial disease.

Arterial Occlusive Diseases↗
PubMed1977

The swollen leg.

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Blood Pressure↗