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Biomedical subjects

J M Friedman

Publications and source records attributed to J M Friedman.

At least 325 records · Page 18Linked to original sources
PubMed1976

A fractured mandible, from initial operation to removal of tantalum mesh. Report of a case.

Report is made of a case of fracture of the angle of the mandible. Treatment was attempted with the Sampson pericortical bone clamp, but was unsuccessful. Routine use of intraosseous wire led to a localized osteomyelitis, without union of the fracture. Treatment then was made with a particulate marrow graft contained within a tantalum mesh screen. The screen was removed 30 months postoperatively.

Adult↗
PubMed1976

Familial carcinoma of the pancreas.

A sibship is reported in which four brothers died of adenocarcinoma of the pancreas in the seventh or eighth decade of life. None of the patients had a history of pancreatitis, other malignant neoplasms, or exposure to a known pancreatic carcinogen. This family seems to exhibit a genetic predisposition to pancreatic carcinoma late in life, but the mode of inheritance and the relative importance of genetic and environmental factors in the development of these tumors are unclear.

Adenocarcinoma↗
PubMed1975

The Jeune syndrome (asphyxiating thoracic dystrophy) in an adult.

A 32 year old American Indian man with the Jeune syndrome (asphyxiating thoracic dystrophy), a condition previously reported only in children, is described. The patient exhibited a cardiomyopathy of unknown etiology and evidence of hepatic and renal disease in addition to characteristic osseous malformations of the thorax, pelvis and extremities. The identification of an established syndrome in this patient permits one to view the combination of abnormalities present in a more coherent manner.

Adult↗
PubMed1975

Management of orofacial infection in patients with chronic renal disease.

Chronic renal failure with resulting imbalance of electrolytes complicated the treatment of a patient with acute facial cellulitis that resulted from a carious molar. The patient's condition improved significantly after three days of hospitalization with meticulous medical and surgical care. He was able to return home after five days.

Adult↗
PubMed1975

Binding of intracellular protein to the erythrocyte membrane during incubation: the production of Heinz bodies.

During sterile incubation of normal human erythrocytes at 37 degrees C., intracellular nonhemoglobin protein is bound to the membrane prior to hemolysis. These studies have characterized this phenomenon further. Protein binding to the membrane began after 12 hours incubation when cellular ATP was depleted and increased to 36 hours incubation. The binding was prevented by adding adenosine or glucose at the start of incubation and was arrested by adding adenosine to regenerate ATP during the course of incubation. However, protein, once bound, was not released by regeneration of ATP. The amount of protein bound was not altered by: (1) addition of Ca++ or EDTA to the medium, (2) blockade of sulfhydryl groups with N-ethylmaleimide, or (3) stabilization of heme-globin bonds by conversion of hemoglobin to cyanmethemoglobin. Conversion of hemoglobin to carboxyhemoglobin by incubations under carbon monoxide inhibited protein binding, but this appeared to be an effect of exclusion of oxygen rather than stabilization of heme-globin bonds since incubation under nitrogen had a similar effect. The morphological counterpart of this chemically-measured membrane-bound protein was visible in red cell ghosts stained with crystal violet as small membrane-associated particles resembling Heinz bodies. Sodium dodecyl sulfate acrylamide gel electrophoresis of membranes of incubated cells revealed a new protein band that was identical to globin monomers. This membrane binding of globin during incubation provides a model for the study of Heinz body formation in clinical disorders.

Adenosine↗