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Biomedical subjects

J M Ferguson

Publications and source records attributed to J M Ferguson.

At least 55 records · Page 3Linked to original sources
PubMed1988

Treatment of bulimia with bupropion: a multicenter controlled trial.

In a placebo-controlled, double-blind study of the unique antidepressant agent bupropion in the treatment of nondepressed subjects with bulimia (bupropion group, N = 55; placebo group, N = 26), we found the drug significantly superior to placebo in reducing episodes of binge eating and purging. In general, side effects with bupropion were minimal. However, four subjects experienced grand mal seizures during treatment with bupropion, a frequency of seizures far higher than observed in previous studies with this drug. Pending a satisfactory explanation for the occurrence of these seizures, we recommend that bupropion not be administered alone to bulimic patients.

Adolescent↗
PubMed1988

Paradoxical worsening of depressive symptomatology caused by antidepressants.

Major depressive episodes can be precipitated by a variety of mechanisms, including the administration of medications. We report four cases in which antidepressant medication appeared to exacerbate a major depressive episode to the point of suicide. Subsequent withdrawal of the initially prescribed antidepressant medication led to a partial remission in each case. These case reports point out the possibility of antidepressant medication precipitating suicidal behavior in depressed patients and underscore the need for careful monitoring of symptomatology during the initial weeks of medication prescription in this population.

Adult↗
PubMed1987

Fluoxetine-induced weight loss in overweight non-depressed humans.

This study shows fluoxetine to be a potent anorectic agent in non-depressed clinically overweight individuals. It is as effective an anorexic compound as a currently available appetite control agent, benzphetamine, and highly significantly more effective than the placebo treatment. A relative lack of serious side-effects and a low abuse potential make it an interesting drug in the slim armamentarium of agents that are used to treat the overweight. If the lack of tolerance to the effects of this drug seen in the long-term studies of depression is confirmed in long-term studies of obese patients, fluoxetine may have a major part to play in the treatment of the obese patient where weight loss is medically indicated. This would include the morbidly obese, the type II diabetic, and the hypertensive patient. Although ideally behavior modification should accompany the drug treatment for obesity, clinical practice indicates that in many cases, patients will not follow through with the behavioral treatment. A strictly medical prescription of an acceptable pharmacologic agent like fluoxetine on a chronic or long-term basis may provide a new possibility for the treatment of these individuals.

Adolescent↗
PubMed1985

Three cases of posttraumatic anorexia nervosa.

Three patients developed anorexia nervosa after car accidents that caused physical injuries. These cases suggest that anorexia nervosa can be secondary to real or perceived figure distortion and that some cases may be caused by it.

Accidents, Traffic↗
PubMed1984

Outpatient treatment of primary anorexia nervosa in adult males.

The majority of studies of primary anorexia nervosa have focused on adolescent females. Relatively little has been written on anorectic males, and there has been scarcely any documentation of the occurrence of this disorder in adult males. The present paper describes three cases of adult-onset primary anorexia nervosa in males. For each case, the history and diagnostic patterns are considered, followed by a discussion of the course of outpatient treatment. The therapy was multimodal and included elements of behavioral contingency management, cognitive therapy, and dynamic psychotherapy. Suggestions are made for future research.

Adult↗
PubMed1984

Trazodone-induced delirium in bulimic patients.

Three bulimic patients with major depressive episodes developed delirium after trazodone administration. These cases raise a question about the susceptibility of bulimic patients to developing delirium when treated with trazodone.

Adolescent↗
PubMed1982

Intussusception--the forgotten postoperative obstruction.

Ten children developed intussusception after laparotomy. The bowel obstruction caused by the intussusception was evident within 8 days of major laparotomy in 8 children and within 39 days in the other two. It developed after the usual postoperative laparotomy ileus, and did not respond to normal non-operative treatment not even to a barium enema. There was one palpable abdominal mass and no rectal bleeding. Only at surgery was the correct diagnosis made. Eight of 10 intussusceptions affected only the small-bowel; most of them were ileoileal, but 2 were ileocolic. Seven of the 10 intussusceptions needed only manual reduction. Postoperative recovery was uneventful.

Abdomen↗
PubMed1978

A rapid behavioral treatment for needle phobics.

A morbid fear of injections and injection paraphernalia can on occasion seriously compromise both the inpatient and outpatient treatment of medical illnesses. Two individuals with a severe needle phobia were treated using participant modeling. In both cases, this very rapid treatment resulted in a remission of symptoms, that in one case persisted at 1 year follow-up post-treatment.

Adult↗
PubMed1978

A new type of chondrodystrophic mutant in the mouse.

Stumpy is a new chondrodystrophic mutant in the mouse. The condition is inherited as a fully penetrant Mendelian recessive, and is not allelic with brachymorphic, achondroplasia, or stubby-three similar, previously described mutants. No chromosomal position has yet been assigned to the gene. Phenotypically, stumpy mice are chondrodystrophic dwarfs with all cartilage-formed bones in the skeleton affected. The condition differs from the usual chondrodystrophy described in mice in that proximal elements in the limbs are affected more than distal ones.

Achondroplasia↗
PubMed1977

Simple techniques to treat medical phobias.

Participant modelling, a behaviourally-orientated treatment technique, is an effect method of treating phobias associated with minor medical procedures or apparatus such as needles or intravenous catheters. The steps in this technique are described and two cases of severe needle phobias successfully treated with participant modelling are presented to illustrate further its application.

Adult↗