Biomedical subjects

J M Dugan

Publications and source records attributed to J M Dugan.

22 records · Page 2Linked to original sources

PubMed1977

Congenital heart disease and prenatal exposure to exogenous sex hormones.

One-hundred and four infants with congenital heart disease were identified from their birth certificates and matched with normal controls. Their gestational histories were examined to see whether they had been exposed to exogenous sex hormones. Exposure was 8-5 times more common among the infants with malformations than among controls. A history of hormone exposure was more common among those patients with multiple malformations, and the exposed infants were also more likely to have died (and to have died earlier) than those who had not been exposed, which suggests that hormone exposure causes severe types of malformations. The commonest type of exposure was to hormone pregnancy tests, which was needless exposure. Only two of the mothers of malformed infants had inadvertently used oral contraceptives in the first trimester.

Abnormalities, Drug-Induced↗

PubMedDate not supplied

Psammoma bodies in fine needle aspirate of the thyroid in lymphocytic thyroiditis.

Psammoma bodies are concentric, laminated microcalcifications that are regarded as nearly specific markers in the thyroid gland for the presence of papillary carcinoma. While psammoma bodies have been seen rarely in some benign thyroid diseases, there appear to be no reports of psammoma body formation in lymphocytic or Hashimoto's thyroiditis. We report a case of Hashimoto's thyroiditis in which psammoma bodies were identified in a fine needle aspiration specimen of the thyroid and in histologic sections of the right thyroid lobectomy; papillary carcinoma was not found in either specimen. We conclude that psammoma bodies may be seen in any benign process, such as nodular goiter or lymphocytic thyroiditis, that produces reactive papillary hyperplasia of thyroid epithelium, as well as in papillary carcinoma. However, the finding of psammoma bodies in a fine needle aspirate without corroborating cytologic evidence of papillary cancer is still an indication for surgical removal of the thyroid nodule since these structures are reliable markers for occult papillary carcinoma of the thyroid, despite the rarity of their formation in benign diseases.

Adult↗

PubMedDate not supplied

Cytologic diagnosis of basal cell (basaloid) carcinoma of the lung. A report of two cases.

Basal cell (basaloid) carcinoma (BC) of the lung is a recently described variant of bronchogenic carcinoma reported to behave as an aggressive, non-small cell lung carcinoma. It may exist in pure form or be mixed with other non-small cell carcinoma patterns. We report the cytologic features in two cases of BC and compare the findings with those in five cases of biopsy-confirmed anaplastic small cell carcinoma, which BC closely mimics.

Aged↗

PubMedDate not supplied

Cytologic diagnosis of measles pneumonia in a bronchoalveolar lavage specimen. A case report.

An immunocompromised employee of our medical center contracted measles during an epidemic and subsequently died of giant cell pneumonia. In this report we discuss the cytologic diagnosis of measles pneumonia and the differential diagnosis of multinucleate giant cells in lung cytology specimens. In the appropriate clinical setting, inclusion-bearing syncytial epithelial giant cells in lung are virtually pathognomonic of measles infection. Cytologic specimens can provide an important early diagnosis.

Bronchi↗