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Biomedical subjects

J M Clark

Publications and source records attributed to J M Clark.

At least 271 records · Page 15Linked to original sources

"Arthrography diagnosis of synovial cysts of the knee.".

A lateral view of the knee in 90 degree flexion can reveal popliteal cysts which do not show on routine arthrography. Flexion causes transfer of intra-articular fluid to the posterior portion of the joint space, lowering pressure within the cyst and allowing it to fill with contrast media.

Humans↗

Uptake of colloidal thorium dioxide by the mouse connective tissue mast cell.

The ability of the mouse mast cell to phagocytize colloidal thorium dioxide, Thorotrast, was investigated employing the mouse connective tissue air pouch. The connective tissue mast cell of mouse was found to have limited capability to ingest the particulate Thorotrast in comparison to the rat peritoneal mast cell which ingested this material readily. Fibroblasts and macrophages in the connective tissue removed injected Thorotrast very rapidly in contrast to mast cells that demonstrated limited phagocytic capabilities. The tissue mast cell of the mouse, therefore, should not be considered a part of the reticuloendothelial system.

Animals↗

Distribution of microglial clusters in the brain after head injury.

The brains of 12 cases of head injury have been submitted to gross pathological study and microscopic examination by the Weil-Davenport method, with special reference to the corpus callosum, internal capsules, and brain-stem in each case. Microglial clusters were observed in 11 out of 12 cases, the most common sites for these being the corpus callosum ipsilateral to the external applied force and the internal capsule and brain-stem contralateral to this applied force. This pattern of distribution of lesions remained constant in all cases. The nature, aetiology, and distribution of these lesions is discussed and it is concluded that such lesions arise from the formation of definite patterns of shearing forces which snap axons. These forces arise from the rotational movements set up within the skull resulting from the relative delay of movement of the brain with respect to the skull and dura mater.

Brain↗

Inhibition of Pseudomonas aeruginosa by hyperbaric oxygen. II. Ultrastructural changes.

The ultrastructure of Pseudomonas aeruginosa cells treated with hyperbaric oxygen for 20 to 24 hr was examined by electron microscopy. A marked difference in the morphology of the nuclear area and cytoplasm of experimental cells was noted when compared to control cells grown under normobaric conditions. This difference was characterized by the absence of a definitive nuclear area and a reduced granularity of the cytoplasm.

Cell Nucleus↗