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Biomedical subjects

J M Chiller

Publications and source records attributed to J M Chiller.

66 records · Page 4Linked to original sources
PubMed1973

Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.

The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.

Adjuvants, Immunologic↗
PubMed1971

Kinetic differences in unresponsiveness of thymus and bone marrow cells.

Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction and spontaneous loss of the unresponsive state. These kinetics appear to be much slower in the bone marrow cells than in the thymus cells. In addition, the dose of deaggregated human gamma globulin needed to induce unresponsiveness in bone marrow cells is much greater than that needed to induce unresponsiveness in thymus cells. Apparently, unresponsiveness in only one cell type is sufficient for the tolerant state to be exhibited by the intact animal.

Animals↗
PubMed1970

Cellular sites of immunologic unresponsiveness.

The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.

Animals↗