Biomedical subjects
Publications and source records attributed to J M Buckler.
Analysis of the heights and weights of about 85% of school entrants in Leeds in 1982 and 1983 showed that the distribution at a mean of 5.3 years is similar to the accepted standard centiles and confirms the appropriateness of the use of these standards at this age.
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Changes in skeletal age and height of 34 Leeds schoolboys were studied in a four year longitudinal survey covering puberty. Tanner and Whitehouse method TW2 was used. In each boy, skeletal age advanced rapidly during puberty, reaching a peak at an age related to that of peak height velocity. The importance of recognising that this acceleration of bone age is normal is stressed, in order to avoid attributing it to other causes.
Monozygotic twins with neurofibromatosis both showed accelerated growth in association with optic glioma. Endocrine abnormalities were similar, but only one of the two had precocious puberty. This identical presentation in twins supports the view that the site of tumour formation is determined during intra-uterine development.
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10 infants are described with pseudohypoaldosteronism, 5 in detail and a further 5 briefly. They all presented with hyperkalaemia, urinary salt-wasting disease, and ostensibly normal renal and adrenocortical function. Diagnosis was established by demonstrating the greatly increased values of plasma renin activity and plasma aldosterone concentration, plus the increased excretion of aldosterone and its metabolites on gas chromatographic and mass spectrometric analyses of urine. The children were treated with sodium chloride supplements, up to 60 mmol/day, but by the time most of the infants were about a year old these could be stopped. Exogenous mineralocorticoids were without effect in those to whom they were administered. The precise aetiology of the condition remains conjectural; lack of renal tubular response to aldosterone seems probable. Pseudohypoaldosteronism may be more common than has been thought and new techniques for investigating salt-wasting disorders may show its true incidence.
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Anthropometric and pubertal status data have been collected on 99 schoolboy gymnasts. There are marked differences compared with standard percentile values for British children. This is most evident in the gymnasts' high biacromial diameters and low skinfold measurements. The anthropometric measurements are tabulated according to pubertal rating. The patterns of training are also presented. The atypical growth patterns of the gymnasts might have resulted from the intensive training requirements of the sport, but alternatively their particular physique may have favoured participation in gymnastics.
An illness due to a leptospiral infection in a boy aged 12 years is described which, in addition to presenting with severe fever, malaise, and aseptic meningitis, showed the rare features of severe bradycardia and erythema nodosum.
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Plasma growth hormone (plasma GH) and blood-glucose concentrations were measured in 23 patients undergoing open heart surgery with moderate hypothermia. A significant increase in blood-glucose concentration occurred with sternotomy and increased during bypass, partly as a result of the exogenous glucose load from the perfusate. Following bypass, the blood-glucose remained above the pre-anaesthetic concentration, and this elevation persisted into the period following surgery. Plasma GH also increased with surgery and remained elevated during perfusion. The highest concentrations occurred following bypass when normal temperature had been regained .
Carbohydrate metabolism was studied in a series of patients with the nephrotic syndrome and compared with a similar number of normal controls. The nephrotic syndrome was associated with a smaller secretion of insulin in response to intravenous glucose and tolbutamide than occurred in normals. In the syndrom fasting serum growth hormone (G.H.) concentrations were increased and did not show the characteristic suppression after glucose administration, and the disappearance rate of glucose (k value) was lower. well marked correlation existed between serum G.H. concentrations and the total urinary protein excreted. These abnormal findings returned to normal in a patient who underwent a repeat study when the nephrotic syndrome had resolved.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.