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Biomedical subjects

J M Booth

Publications and source records attributed to J M Booth.

At least 19 recordsLinked to original sources
PubMed1999

Long-term outcome and colonic motility after the Duhamel procedure for Hirschsprung's disease.

BACKGROUND/PURPOSE: The aim of this study was to investigate long-term functional outcome and colonic motility in children who had undergone the Duhamel-type operation for Hirschsprung's disease (HSCR). METHODS: All patients (n = 91) who underwent the Duhamel or Lester Martin Modified Duhamel operation for HSCR from 1980 to 1991 were included in the study. Twenty-two healthy age-matched children were used as controls. Functional outcome was assessed by questionnaire (response rate 100%). Total and segmental colonic transit time (CTT) was determined using the saturation method (80% participation rate). RESULTS: Outcome scores were significantly worse in the study group for patients with rectosigmoid (RS, P < .001), long segment (LS, P < .001), and total colonic (TC) aganglionosis (P < .05), when compared with controls. The CTT was significantly prolonged in the RS group (P = .01) compared with LS, TC, and control groups; this was caused by prolonged "rectosigmoid" transit in the RS group compared with controls (P = .012). There was a positive linear correlation (P = .0002) between age and outcome score in patients with RS disease unrelated to CTT. Nine patients required a late long-term enterostomy. A satisfactory outcome (defined as outcome score > or = 10th percentile of the control group, and absence of stoma or requirement for major revisional surgery) was seen in only 42% of patients overall and in 79% of patients over 14 years of age. CONCLUSIONS: The Duhamel procedure, in common with other pull-through procedures, is associated with significant long-term morbidity, the aetiology of which is poorly understood.

Adolescent↗
PubMed1998

Functional results following the antegrade continence enema procedure.

BACKGROUND: Forty children who underwent the antegrade continence enema (ACE) procedure for faecal soiling were studied to determine factors predictive of outcome. METHODS: There were four patient groups: (1) ambulant with spinal dysraphism (n = 13), (2) wheelchair bound with spinal dysraphism (n = 14), (3) ambulant with miscellaneous disorders (n = 11) and (4) wheelchair bound with miscellaneous disorders (n = 2). Effectiveness of the procedure was assessed using technical evaluation and quality-of-life improvement (QOLI) scores (0-5). Objective assessment included colonic transit time (CTT) and anorectal manometry. Median follow-up was 21 (range 5-37) months. RESULTS: Some 28 of 40 children achieved continence. The procedure was reversed in four of 40 children. Of the other 36 children with a functioning ACE stoma, all reported improvement in quality of life (mean QOLI score 3.5). There were no significant differences in technical evaluation score, QOLI score, CTT, manometry findings or continence between ambulant groups and the wheelchair-bound group with miscellaneous disorders. QOLI score, anorectal squeeze pressure and continence were significantly poorer in those who were wheelchair bound with spinal dysraphism. Absent squeeze pressure was associated with poor outcome. CONCLUSION: Wheelchair-bound children with spinal neuropathy have a poorer outcome following the ACE procedure. Although ACE is an effective method of promoting faecal continence, it is essential to determine the aetiology of incontinence and sphincter function before operation.

Adolescent↗
PubMed1993

Effect of pre-milking teat dipping on clinical mastitis on dairy farms in England.

Two trials were conducted to investigate the effect of pre-milking teat dipping (PMTD) on mastitis caused by environmentally associated pathogens. The first trial showed considerable variation in effect between herds, so a second, larger trial was conducted. In this second trial a comparison of the rate of clinical mastitis was made between nine matched pairs of dairy herds over 24 weeks of the winter housed period. All herds were near the national average incidence of mastitis before the trial. One member of each pair used their normal method of udder preparation throughout the trial and disinfected all teats after milking with an iodophor disinfectant. In the other nine herds the preparation of all teats, at all milkings, included dipping in a 0.25% available iodine disinfectant, which was left on the teat for 30 s. Every teat was then wiped with a paper towel before cluster attachment. There was no difference in the overall rate of mastitis or the incidence of mastitis caused by any particular type or group of pathogens between the trial groups of herds. Both groups showed a reduction in mastitis compared with the previous winter. Although there were apparent benefits in some pairs of herds there was no overall benefit. In comparison with the previous winter the control herds reported a greater reduction in mastitis than the PMTD herds. The effect of trial supervision on normal practice gave a benefit which overwhelmed any effect of PMTD. There appeared to be no effect of PMTD on the total bacterial count, cell count or iodine content of bulk tank milk. There appears to be no justification for wholesale use of PMTD although most farms and risk groups could benefit from better attention to conventional mastitis control.

Animals↗
PubMed1992

A comparison between the dental health of 3-year-old children living in fluoridated Huddersfield and non-fluoridated Dewsbury in 1989.

A study was undertaken to compare the prevalence of dental caries and developmental defects of enamel between 3-year-old children who were lifelong residents of fluoridated areas of Huddersfield (1 ppm F) and non-fluoridated Dewsbury (less than 0.3 ppm F). An interview was also conducted with the parents of the children to provide information regarding previous dental experiences. The study populations were identified using the national child health system. The mean dmft was 0.30 in Huddersfield and 0.74 in Dewsbury. The percentage of children who had experienced dental caries and the percentage with carious teeth were significantly lower in the fluoridated area. The Dewsbury children had suffered more toothache. There was a significantly higher number of children in Huddersfield with diffuse enamel defects on their upper and lower first molars. This study has also demonstrated that the national child health system provides a method for obtaining a random sample of pre-school children from the general population, thus avoiding the problems associated with studies using selected populations. Fluoridation in Huddersfield ceased in October 1989 and it is hoped that this decision will be reversed as soon as possible.

Child, Preschool↗
PubMed1991

Studies on the incidence of clinical mastitis and blood levels of vitamin E and selenium in dairy herds in England.

In a trial conducted in the south of England in January to February 1989, blood samples were obtained from nine dairy herds with more than 30 cases of clinical mastitis/100 cows and from nine herds with less than 30 cases/100 cows during the previous 12 months. Whole blood glutathione peroxidase (GSHPx) activity and plasma vitamin E concentration were determined for 12 cows in each herd. The mean (+/-sd) values for the herds with the lower incidence of mastitis were 7.57 +/- 1.86 micrograms/ml plasma vitamin E and 23.8 +/- 22.8 U/ml rbc GSHPx activity, compared with 7.74 +/- 1.69 micrograms/ml plasma vitamin E and 20.61 +/- 8.8 U/ml rbc GSHPx activity for the herds with the higher incidence of the disease. These values indicate that the vitamin E levels were generally adequate but that some animals and herds had low GSHPx activities, suggesting that their diets may have contained inadequate selenium. The activities of GSHPx and the vitamin E levels in plasma were not significantly different in the two groups of herds, and no relationship was found between the two nutrients and the incidence of clinical mastitis. However, there was a significant negative correlation between the activity of GSHPx and the bulk milk cell counts in the herds with a low incidence of mastitis suggesting that there was an association between the incidence of subclinical mastitis or inflammation and the selenium status of these herds.

Animals↗
PubMed1988

The milk progesterone test as an aid to the diagnosis of cystic ovaries in dairy cows.

Two field trials were carried out by five experienced veterinary surgeons to evaluate the milk progesterone test as an aid to the differential diagnosis of cystic ovaries in dairy cows. Of 200 cystic cows, 71 per cent were diagnosed clinically as follicular and 29 per cent as luteal cases; 80 per cent of the cases occurred in the six winter months November to April. The progesterone assay indicated that the diagnosis was correct in 84 per cent of the follicular cases but only 54 per cent of the luteal cases. Seventy-four per cent of the confirmed cystic cases responded to treatment within two weeks according to milk progesterone tests and there were no significant treatment differences. Overall, 80 per cent of the cows became pregnant on average 38 days after treatment having received an average of 1.70 inseminations each. Milk yield data in the first trial indicated that the cystic cows were not significantly higher yielders than their herd-mates.

Animals↗
PubMed1988

Progress in controlling mastitis in England and Wales.

Mastitis in England and Wales has been controlled over the past 20 years while the average size of dairy herds has doubled to 65 cows. The incidence of clinical mastitis has been reduced from approximately 120 to 150 cases per 100 cows to less than 50 cases. The limited data on the prevalence of subclinical mastitis indicate that it has been reduced from over 50 per cent of cows infected to less than half this level. The application of the major mastitis control measures on the farm has doubled over the period 1973 to 1983 and had reached 66 to 90 per cent for individual measures by 1983. The national mean cell count in milk has been reduced from 573,000 to 352,000 cells/ml between 1971 and 1986, and the proportion of herds having annual mean cell counts below 300,000 cells/ml has increased from 15.7 per cent to 40.7 per cent in the last eight years.

Animals↗
PubMed1986

Testing for antibiotic residues in milk.

Milk from dairy farms in England and Wales has been tested regularly for antibiotic residues since 1965. The sensitivity of the test organism was 0.02 iu/ml penicillin or equivalent until the change to 0.01 iu/ml in January 1986. In 1984-85, 99.6 per cent of the 2,000,000 milk samples tested passed the test and there was an average of 695 failures per month. From 7500 on-farm investigations over the two years 1983-85 the most frequent reasons suggested by farmers for their test failures were not withholding milk for the full withdrawal period (19.3 to 16.5 per cent) and accidental transfer of milk (16.3 to 16.7 per cent). Lactating and dry cow intramammary antibiotic preparations were held responsible for rather over 50 per cent and 25 per cent respectively of the failures in both years.

Animals↗
PubMed1986

Use of a new and rapid milk progesterone assay to monitor reproductive activity in the cow.

A new and rapid enzyme-amplified immunoassay (AELIA) has been developed for the measurement of progesterone in milk. The AELIA system is a non-isotopic method that gives results within 35 minutes. Milk progesterone concentrations measured in 10 cows sampled daily at various stages of the reproductive cycle were very similar to those recorded by a validated radioimmunoassay. The results show that the speed and sensitivity of the AELIA system would make it possible to diagnose pregnancy rapidly at about 24 days after insemination, to predict the onset of behavioural oestrus from decreasing progesterone values during the third week after a preceding oestrus, and to obtain a daily record of milk progesterone levels in animals treated for infertility of ovarian origin.

Animals↗
PubMed1986

Intramammary antibiotic preparations and their withholding times.

The test for antibiotic residues in milk carried out by the Milk Marketing Board (MMB) of England and Wales was increased in sensitivity from 0.02 iu/ml penicillin or equivalent to 0.01 iu/ml on January 1, 1986. The Veterinary Products Committee (VPC) has just completed a review of those intra-mammary antibiotic preparations which had licences of right. When assessing data for product licences the VPC decided that the concentration of antibiotic residues in milk should not exceed the concentrations listed in the 1969 Report of the Joint FAO/WHO Expert Committee on Food Additives. In this publication the level of 0.006 ppm for penicillin corresponds to 0.01 iu/ml which is the level that the MMB will also be using.

Animals↗
PubMed1984

Use of a conductivity meter for the detection of subclinical mastitis.

The conductivity of milk from 164 cows in four herds was measured. There were significant differences between the normal and the mastitic quarters in each of the four herds. However, there was a marked difference in conductivity levels between the herds, the mean conductivity of the normal quarters in one herd being higher than that of the mastitic quarters in another herd. In a trial using a hand-held mastitis detector on 123 cows from three herds, 91 per cent of the 106 mastitic quarters were detected. However, 33 per cent of the 315 normal quarters also gave a positive reading.

Animals↗