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Biomedical subjects

J M Bonnetblanc

Publications and source records attributed to J M Bonnetblanc.

16 recordsLinked to original sources
PubMed1979

[Pachydermatoglyphy. A sign of malignancy for acanthosis nigricans (author's transl)].

The pachydermatoglyphy corresponds from the clinical point of view to a diffuse palmo-plantar keratodermia, of a yellowish color, characterised by a rough thickening of the finger prints. The presence of the pachydermatoglyphy has been pointed out in six cases of malignant acanthosis nigricans. This was already found in previous descriptions. Pachydermatoglyphy is specially found in malignant acanthosis nigricans, but we have also observed such cases in erythrokeratodermia with pilar keratosis and deafness.

Acanthosis Nigricans↗
PubMed1979

[Betablockers and skin (author's transl)].

Up to now betablockers, with the exception of erythermalgia, have been rarely used as therapeutic agents in dermatology. However, cutaneous drug reactions are numerous. A review of the literature about practolol cutaneous effects and their possible mechanisms has shown that a great variety of clinical states can be encountered. All betablockers have been known to produce harmful side effects, although less frequently. In conclusion, the description of each new case of cutaneous drug reaction probably due to betablocker must be assessed.

Adrenergic beta-Antagonists↗
PubMed1977

[Anticytoplasmic antibodies of human epidermal cells (author's transl)].

Antibodies reacting with the cytoplasm of epidermal cells (E. C. A.) were defected by indirect immunofluorescence (I.I.F.) studies of 255 sera in various dermatoses (8 p. 100) and significantly more frequently (46 p. 100) in bone marrow transplanted patients having skin lesions. Bound E.C.A. were only found in two cases. E.C.A. were found to be devoided of any diagnostic value. E.C.A. were interpreted as the result of a skin injury liberating skin antigens which stimulated their production. The reaction of E.C.A. in I.I.F. on human skins substrates showed three different patterns; in some cases only the basal cell layer was stained; in others only the supra basal layers were stained; in other all the layers were stained. A serum was shown to be able to give the three patterns of reaction (or no reaction at all) if different human skins were used as substrate. Autologous skins never gave a basal cell layer staining. These findings support the facts that (I) there is antigenic differences between the basal cell layer and the supra basal layers (with regard to the cytoplasmic antigens) (II) these antigens may be different from one subject to the other, supporting the allogeneic nature of this system. Therefore, E.C.A. are regarded as a useful marker of the human skin cytoplasmic antigens.

Animals↗
PubMedDate not supplied

[Skin fibrosis in hyperthyroidism treated by sotalol and radioactive iodine (author's transl)].

The authors present detailed data about skin fibrosis appearing in hyperthyroidism treated by Sotalol and radioactive iodine. Cutaneous thickening is discovered quite rapidly when the patient is monitored daily (as in case 4). It is asymptomatic and no other features of scleroderma are found. Regression occurs within 4-10 months. Histologically, fibrosis is located in the entire dermis. Dermal appendages are normal and no inflammatory changes occur. No anomalies of collagen structure and fibroblasts have been observed ultrastructurally. Immunological studies (direct immunofluorescence of the skin, lymphocyte transformation and leucocyte migration tests with Sotalol) were normal. The mechanism is unknown, but an immunological or a toxic one is excluded; however a pharmacological action is possible. The role of other betablockers must be assessed by a randomised study.

Epidermis↗