Biomedical subjects

J M Berman

Publications and source records attributed to J M Berman.

5 recordsLinked to original sources

PubMed1979

Peripheral facial paralysis secondary to metastatic malignant melanoma. A clinicopathologic report.

We report a case of disseminated malignant melanoma in which the initial sign was an isolated peripheral facial palsy on the left side. The cause of the palsy was established five months later, with the appearance of metastatic axillary nodes. The temporal bones demonstrated tumor infiltration within the marrow spaces of the petrous apices bilaterally. The left facial nerve was also extensively involved with melanoma to the level of the geniculate ganglion.

Autopsy↗

PubMed1979

Metastatic tumors in the temporal bone--a pathophysiologic study.

Nineteen temporal bones were examined from 11 patients who had metastatic temporal bone disease from a distant primary. The salient clinical features were: the high incidence of occult temporal bone involvement (7 of the 10 clinically documented cases), the considerable incidence of melanoma (3 of 10) and the variable correlation between clinical findings and pathologic localization of tumor in the temporal bone. Pathologic examination revealed two distinct modes of tumor spread within the temporal bone: 1) vascularosseous (petrous apex, mastoid, middle ear, external canal); and 2) perineural (nerves in IAC branches, labyrinthine endorgans). Every case was involved by one or both or these routes and no case of CSF-borne metastasis to the perilymphatic space was seen. The external canal was involved extensively in spite of an intact tympanic membrane. Since the presence of symptomatic or occult metastases in the temporal bone affects treatment and prognosis, they must be actively sought by the clinician.

Adenocarcinoma↗

PubMed1978

Vertigo after head injury--a five year follow-up.

Three hundred and twenty-one head injury patients investigated at the Workmen's Compensation Board Hospital and Rehabilitation Centre were studied. The patients were classified into two groups, minor and moderate according to the duration of post-traumatic amnesia. Post-traumatic vertigo was a significant symptom in 34 per cent and 50 per cent of the minor and moderate groups respectively. Based on the findings of full otoneurologic and vestibular examination, objective vestibular disorder was noted in 40 per cent and 65 per cent of the two vertiginous groups respectively. An approach to the interpretation of vestibular and oculomotor abnormalities is outlined in order to assign a peripheral (end organ or nerve), central (brainstem or cerebellar) or undertermined localization. Hearing loss occurred in 20 per cent of the minor and 72 per cent of th e moderate head injury patients tested. A five-year post head injury follow-up was available with respect to recovery of vertigo and work rehabilitation. The results of this follow-up are discussed.

Adolescent↗

PubMed1978

[Early effect of Crotalus durissus terrificus venom on kidney circulation].

Local blood flow was measured in renal cortex (1 mm below cortical surface) by means of the hydrogen clearance method in urethanized rats. Recording of blood pressure from femoral artery was performed. Crotalus durissus terrificus venom injection (one mg/kg i.v.) significantly decreased cortical blood flow at 10 min, without a significant arterial pressure modification. Posterior injection of mannitol 200 mg induced a significant increase in cortical blood flow, although initial values were not reached. Electron microscopy showed thromboses in the glomerular capillaries 35 minutes after venom injection. It is suggested that the precocious effect of this venom on renal cortical blood flow may be instrumental in the development of the renal acute insufficiency induced by Crotalus durissus terrificus venom.

Animals↗

PubMed1977

Nasal aspects of cystic fibrosis in children.

Despite the extraordinary prevalence of upper respiratory allergy and infection in children nasal polyposis is an extremely rare condition. Seven cases of cystic fibrosis are presented in order to demonstrate the nasal aspects of the disease. All but one had nasal polyposis. The literature has been reviewed with particular reference to clinical, radiological and histo-pathological features. Conservative treatment is stressed.

Child↗