[Current indications, incidents and complications of macrolides and related substances].
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Biomedical subjects
Publications and source records attributed to J M Beauvieux.
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Sodium plasma level was followed every three months in 70 non insulin dependent diabetic patients; 112 prescriptions were performed. Five different oral hypoglycemic drugs were used but patients were taken no more than one drug in the same time. 21% of prescription were associated with a low sodium plasma level but it was beneath 129 meq in only 8% of them; a low sodium plasma level was observed with every oral hypoglycemic agent; when the drug was interrupted a normal sodium plasma level was restored; when patients were put under another agent, hyponatremia did not recidive. 67% of patients were free of any symptom. Interference with biological parameters, age of the patients, duration of diabetes and other therapy are studied.
We report the case of a patient born in 1923 who had been treated with metformin since 1977 and experienced panic attacks. Lactic acid levels, measured during an attack for the first time since metformin was prescribed, were found to be elevated on two occasions. Metformin was discontinued, and during a 9-month follow-up period the patient was free from any psychiatric disorder. The role of lactic acid in the triggering of panic attacks is discussed.