[Computerization of results of the International Workshop on Histocompatibility held in Cuba (author's transl)].
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Biomedical subjects
Publications and source records attributed to J M Ballester.
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T lymphocyte counts in the peripheral blood, lymphocyte response to phytohaemagglutinin (PHA) and delayed hypersensitivity reactions were studied in ten patients with paroxysmal nocturnal haemoglobinuria (PNH). Delayed hypersensitivity was abnormal in most patients and in vitro studies revealed impaired lymphocyte transformation to PHA in 50 per cent of the cases. These tests gave evidence of a functional alteration of lymphocytes in some PNH patients. The hypothesis of a disorder originated in a pluripotent lymphohaematopoietic stem cell is suggested.
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Viridicine, a new bacteriocine, was extracted from whole cells of Aerococcus viridans by repeated washings with Tris-HCl 5 X 10(-3) M pH 8,1, NaCl 1 M. A crude preparation of the macromolecule was not inactived by heating for one hour at 50 degrees C and was sensitive to the action of protease, lipase and catalase. The molecular weight was about 100,000. A large number of Gram-negative and Gram-positive bacteria were sensitive to viridicine action.