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Biomedical subjects

J M BARNES

Publications and source records attributed to J M BARNES.

At least 37 records · Page 2Linked to original sources
PubMed1959

A comparison of the antigenicity characteristics of mixed antigens in the child and the guinea-pig.

Parallel dose-response experiments were carried out in infants and guinea-pigs employing mixed antigens, e.g., diphtheria formoltoxoid (plain) mixed with H. pertussis vaccine, and with H. pertussis vaccine and tetanus toxoid (plain).It is found that the slopes of the dose-response regression lines, particularly in respect of the diphtheria antitoxin responses, are so greatly different in the two species that the guinea-pig cannot be used as a test-animal for response in children and that the concept of "units of antigenicity" receives no practical support.Since the adjuvant effect of pertussis vaccine on formol-toxoid appears to be inconstant, it is suggested that this property be regarded solely as a "bonus" to the intrinsic antigenic activity of the toxoid and that, for purposes of laboratory control of such mixed antigens, the toxoids should be tested against the International Toxoids (plain) alone, i.e., not mixed.

Animals↗
PubMed1957

Control of health hazards likely to arise from the use of organo-phosphorus insecticides in vector control.

The widespread use of DDT and the chlorinated hydrocarbon group of insecticides for the control of mosquitos and flies has led to the emergence of resistant strains of flies. Where the DDT group of insecticides is ineffective for the control of resistant insects, it appears that the use of the organo-phosphorus group of insecticides may be an alternative. However, it seems probable that their introduction and application under the same conditions in which DDT has been safely used might carry serious risks to the health of the men who apply them. In this paper, the authors indicate what these dangers are, how they manifest themselves, and how they might be controlled. Four methods of blood-cholinesterase determinations, carried out in the laboratory and in the field, are described in an annex.

Cholinesterases↗