[Treatment of insomnia].
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Biomedical subjects
Publications and source records attributed to J M Alby.
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We have performed a national multicentric atrial in psychiatry, collecting 546 patients with neurotic inhibition. The efficacy of carpipramine was evaluated in this disease. A transnosographic and epidemiologic analysis of this syndrome was realized on this group of out patients. The statistical study by a factorial analysis of correspondences shows the epidemiological and symptomatic characteristics of inhibition. The endpoints were DSM-III criteria of chronic anxiety, adaptation disorders and functional sexual disorders on the first axis and different types of personality on the second axis.
This new instrument to evaluate anxiety, the F.A.R.D. (Ferreri anxiety rating diagram - 1987) has been conceived to appreciate the repercussions of anxiety on the activity of the subject. It realizes a special image of anxiety. It has been studied, by both psychiatrists and general practitioners in 320 patients included on generalised anxiety disorders criteria (following DMS III). The validation has been realised in a study of prazepam for 81 patients. The F.A.R.D. is based upon 12 items. The factor analysis has retained 4 factors explaining 66% of the whole variance. These 4 factors composed by 3 items each are: relational, somatic, vigilance, cognitive. This new instrument, the F.A.R.D.: evaluates the intensity of anxiety, precision, the shape of anxiety, specifies sub-groups of anxiety, allows a following of evolution, appreciates the pharmaco-clinical profile of the anxiolytic drug prescribed.
A national multicentric trial has included 402 depressed patients (DSM III Criteria) and has validated diagram HARD by MADRS. A constant and similar decrease in the total of the two rating scales has been shown at several times of assessment, Day 0, 10, 20, 60, and 90. High coefficents of correlation are found between HARD and MADRS. The sensitivity to change under treatment (mianserin 60 mg) is equal for the two rating scales.
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The authors are focusing on the absence of inhibition of H reflex in depressed patients compared with normal subjects, and this during the voluntary hyperventilation and the zazzo "barrage" tests.