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Biomedical subjects

J Luthman

Publications and source records attributed to J Luthman.

At least 109 records · Page 6Linked to original sources
PubMed1984

Effects of GM1 ganglioside on developing and mature serotonin and noradrenaline neurons lesioned by selective neurotoxins.

The effect of exogenous GM1 ganglioside on selective neurotoxin-induced lesions of serotonin (5-HT) and noradrenaline (NA) neurons in both the central and peripheral nervous systems has been investigated in developing and adult rats and mice by employing neuro- and histochemical techniques. 5,7-Dihydroxytryptamine (5,7-HT) was used to lesion 5-HT neurons, and 6-hydroxydopamine (6-OH-DA) was used to lesion NA neurons. In most lesion models investigated the neurotoxin causes primarily an axonal nerve terminal damage without notably affecting the perikarya. There was no evidence indicating that GM1 interferes with the primary and direct neurodegenerative actions of 5,7-HT or 6-OH-DA on 5-HT and NA nerve terminals, respectively. In all lesion models GM1 had in the chronic stage a counteracting effect on the neurotoxin-induced nerve terminal lesion or enhanced regrowth. The present results are compatible with the view that GM1 has a regrowth-stimulating effect and/or protective actions against secondary retrograde degeneration following the initial nerve terminal lesion induced by the neurotoxin.

5,7-Dihydroxytryptamine↗
PubMed1983

Epidural versus intramuscular fentanyl. Analgesia and pharmacokinetics in labour.

In a randomised double blind trial, 36 patients in the first stage of labour received either epidural or intramuscular fentanyl at the same time as the epidural test dose of bupivacaine. Analgesia was more rapid in onset and more complete in the epidural fentanyl group. Supplementary doses of bupivacaine were required within the first hour in 62% of the intramuscular fentanyl group compared with only 16% in the epidural group. Plasma fentanyl concentrations showed wide interindividual variation, but after epidural fentanyl the peak occurred earlier. There was no correlation between analgesia and plasma fentanyl concentration, and epidural fentanyl produced superior analgesia but a systemic contribution to this effect cannot be ruled out.

Adult↗
PubMed1983

Hypotension following cimetidine administration during cardiopulmonary bypass.

Intravenous administration of cimetidine may occasionally cause profound hypotension. Cimetidine 200 mg was administered as a bolus injection to patients whilst on cardiopulmonary bypass and subsequent changes in systemic arterial pressure were recorded. A statistically significant fall in arterial pressure was observed (p less than 0.001), which was attributable to a fall in systemic vascular resistance.

Blood Pressure↗
PubMed1979

[Fluorimetric determination of ampicillin in calf serum (author's transl)].

The serum concentrations of ampicillin was determined in calves after oral and parenteral administration. Ampicillin was analyzed by a fluorimetric method which was found simple and reliable. When ampicillin at a dose of 12 mg/kg was given in a milk replacer, the serum concentrations was too low to be effective even against all ampicillin sensitive bacteria. This method of treatment may be used only in the treatment of enteritis, as it is reported in the literature that high ampicillin concentrations occur in the intestinal content and the intestinal mucosa. After intramuscular injection of recommended doses (4-10 mg/kg), high serum concentrations was reached soon after the injection. The drug is, however, excreted rapidly and treatment should be repeated at shorter intervals than usually is recommended.

Administration, Oral↗
PubMed1977

Feeding-induced hypocalcaemia. Preliminary studies in sheep.

The effect of feeding on calcium metabolism was studied in sheep. When crushed oats or pelleted concentrate was added to the diet of hay-fed sheep, there was a profound decrease in serum calcium. Serum calcium fell in spite of an increased daily intake of calcium.

Animal Feed↗