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Biomedical subjects

J Lumley

Publications and source records attributed to J Lumley.

At least 181 records · Page 10Linked to original sources
PubMed1977

Respiratory effects of etomidate.

The respiratory effects of etomidate 0.3 mg/kg were studied in patients premedicated with either diazepam and atropine or papaveretum and hyoscine. The incidence of apnoea was 40% in those who received the non-narcotic premedication, compared with 27% in those who received the opiate. Those premedicated with diazepam and atropine showed a significant increase in respiratory frequency which was associated with a significant increase in minute volume 4 min after induction of anaesthesia. No such increase occurred in those premedicated with papaveretum and hyoscine. It would appear that the effects of etomidate on respiration are less than those of other i.v. induction agents, but involuntary muscle movement during induction remains a problem.

Analgesics, Opioid↗
PubMed1976

Effect of dose and premedication on induction complications with etomidate.

The induction characteristics of etomidate, a new i.v. hypnotic agent, were studied in 400 patients. Two hundred were premedicated with atropine and anaesthesia was induced with 0.2, 0.25, 0.3 or 0.35 mg/kg of etomidate. The remainder received one of four standard premedications and anaesthesia was induced with etomidate 0.3 mg/kg. Involuntary muscle movements occurred in more than 60% of patients receiving atropine alone. The frequency was reduced in the second group, but remained unacceptable in over 8% of patients. The incidence of other excitatory phenomena, such as cough and hiccup, was 10% approximately. Cardiovascular changes were minimal and no serious allergic phenomena were observed. Nausea and vomiting occurred after surgery in up to 30% of patients and was unrelated to the dose of etomidate or to premedication. Pain on injection occurred in up to 80% of patients when the drug was injected into small peripheral veins and occurred in more than 7% when using more normal veins.

Adult↗
PubMed1975

Etomidate, a new water-soluble non-barbiturate intravenous induction agent.

This paper describes clinical experimence, in 100 patients, with the new non-barbiturate, water soluble induction agent, etomidate. This drug produces sleep in one arm/brain circulation-time. There was no effect on pulse-rate, a slight fall in blood-pressure, and a low frequency of apnoea. Involuntary movements were noted, and in some patients these were severe. Etomidate warrants further evaluation as an intravenous induction agent.

Adolescent↗
PubMed1975

Insertion of central venous catheters through arm veins.

The position of the tip of a central venous catheter inserted through an arm vein is not influenced by the arm or by the vein chosen. There may be some advantage in inserting the catheter with the arm at the patient's side, although there seems to be no benefit from turning the patient's head towards the side of insertion. Because the most common malposition from an apparently uneventful insertion is due to the catheter tip entering the internal jugular vein, neck compression has been established as a useful test. If the catheter tip is well into the internal jugular vein, compression on that side of the neck should cause a rise in the recorded pressure of 10 or more cm H20. This rise should not occur on compression of the other side of the neck. We wish to emphasize that it is important to confirm radiographically the position of the catheter tip.

Arm↗
PubMed1975

Anaesthetic considerations in chronic renal failure.

This paper discusses the anaesthetic problems presented by patients in chronic renal failure. The anaesthetic agents and techniques used in 181 patients who underwent 941 operations (including 218 renal transplants) are described.

Acid-Base Equilibrium↗
PubMed1975

Some observations on blood microfilters.

Under laboratory conditions 3 types of filter designed to prevent the passage of microemboli into the circulation during the transfusion of stored blood were compared with the standard Baxter BR10 filter, designed only to hold back macroemboli, in respect of resistance to blood flow and damage to the cellular elements of the blood. In both respects the Pall Ultipor microfilter proved more efficient than the Swank IL200 microfilter and the Bentley Polyfilter (PF-127) and, except with 3-week-old blood, was comparable to the Baxter filter.

Blood Transfusion↗