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Biomedical subjects

J Lumio

Publications and source records attributed to J Lumio.

53 records · Page 3Linked to original sources
PubMed1983

Occurrence of antibodies to teichoic acid in patients with diseases other than staphylococcal infection.

To determine the usefulness of the teichoic acid antibody (TAA) test in conditions where unspecific viral and bacterial antibodies are often encountered, we measured TAA by the gel-diffusion method in 475 patients without known staphylococcal disease; they included 213 patients with arthritis, 108 with liver diseases, 100 with gastro-intestinal disorders and 54 with acute pharyngitis. Positive controls were 104 patients with Staphylococcus aureus bacteraemia and 203 healthy adults were negative controls. Thirteen (6%) of the healthy adults had positive TAA titres (greater than or equal to 4), and the highest titre was 8 in two people (1%). Positive titres were found in 38% of patients with S. aureus bacteraemia and high titres (greater than or equal to 8) were seen in 24%. Among the patients with arthritis, positive TAA titres were found significantly more often than in healthy controls in patients with Yersinia arthritis (p less than 0.01) and systemic lupus erythematosus (SLE; p less than 0.02). In other patient groups, the percentage of positive TAA titres did not differ significantly from that in healthy adults. Eight (2%) of the 475 patients without known staphylococcal infection had TAA titres greater than or equal to 8 but these high titres were not associated with any particular disease group. Only two of these eight patients had slightly raised antibody to staphylococcal alpha-haemolysin. We conclude that the TAA test cannot be used as a reliable indicator of septic staphylococcal disease in patients with Yersinia arthritis or SLE, but that in general, TAA titres greater than or equal to 8 point strongly to S. aureus infection even in patients with autoimmune or liver diseases.

Adolescent↗
PubMed1983

Lymphocyte subpopulations and reactivity during and after infectious mononucleosis.

T- and B-lymphocyte numbers, as well as lymphocyte reactivity to mitogens in vitro, were studied and correlated to other laboratory tests during the acute phase of infectious mononucleosis (30 patients) and up to one year thereafter. During the acute disease an absolute increase in both T- and B-lymphocyte numbers was recorded, the relative increase in B-lymphocytes occurring at the start. B-lymphocyte numbers fell after the second week and T-lymphocyte numbers after the fourth week of disease. Lymphocyte activation was impaired in all patients during the acute phase and was still significantly impaired for some mitogens after 6-9 months. Very few correlates between lymphocyte tests and other laboratory and clinical parameters were found.

Adolescent↗
PubMed1982

[Viral hepatitis].

Explore the source record for details and available documents.

Hepatitis, Viral, Human↗
PubMed1981

Q fever in Finland: clinical, immunological and epidemiological findings.

Clinical, immunological and epidemiological features of 14 human cases of Q fever diagnosed at Aurora Hospital are presented. All patients had an acute febrile disease and 9 (64%) had respiratory symptoms, 4 (29%) verified pneumonia, and 9 (64%) hepatitis, which in 4 biopsied cases proved to be granulomatous. Presence of circulating immune complexes was shown in 10/11 patients investigated by the platelet aggregation test (PAT) and the platelet iodinated protein A (PIPA) test. Q fever is not known to be endemic in the Nordic Countries. However, the causative agent, Coxiella burnetii, should tolerate our climate and there is a rich potential animal reservoir. All patients had visited some endemic area shortly before they were taken ill. In 3 cases the interval between arrival in Finland and the onset of symptoms was more than double the reported maximal incubation period, namely 69, 75 and 88 days. We suggest that these patients acquired the infection after their return to Finland from their clothing or from souvenirs. If so, Q fever could be acquired by this mechanism by persons who have never visited an area where the disease is endemic.

Adult↗
PubMedDate not supplied

Echocardiographic follow-up of diphtheric myocarditis.

We report the first case of diphtheric myocarditis documented by serial electrocardiography and echocardiography. The electrocardiographic changes preceded the contraction abnormalities by 3 weeks. During a prolonged neurologic disease with extensive polyneuropathy, the patient had only subtle clinical signs of myocarditis. In patients with diphtheria, electrocardiographic changes may warrant repetitive echocardiographic examinations.

Adult↗