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Biomedical subjects

J Lukacs

Publications and source records attributed to J Lukacs.

10 recordsLinked to original sources
PubMed1986

Breakeven analysis.

Breakeven analysis provides insight to relationships between price, fixed costs, variable costs and volume. When combined with the contribution-margin approach, breakeven analysis can provide the answers to key questions that form the basis of many decisions facing health-care professionals and managers.

Accounting↗
PubMed1981

Effects of hycanthone and praziquantel on monoamine oxidase and cholinesterases in Schistosoma mansoni.

The effects of hycanthone and praziquantel on the activities of monoamine oxidases and cholinesterases were studied in the 600-g supernatant from homogenates of Schistosoma mansoni and mouse liver or brain. Hycanthone was shown to be a very potent inhibitor of monoamine oxidases from worms and mouse liver. Hycanthone also inhibited the specific and nonspecific cholinesterases of S. mansoni, but cholinesterase from mouse brain was not affected significantly by this drug. Praziquantel showed no effect on monoamine oxidase from mouse liver or the parasite; however, it was slightly inhibitory to S. mansoni cholinesterases at very high concentrations. Mouse brain cholinesterase required an even higher concentration of praziquantel to observe inhibition. The inhibition of monoamine oxidase in S. mansoni by hycanthone adds a new mode of action to our knowledge of this compound, and suggests another possibility for the development of future anthelminthics.

Animals↗
PubMed1980

Development of a cell-free protein-synthesizing system from Schistosoma mansoni and a comparison of the effects of hycanthone and praziquantel on this system.

A cell-free, protein-synthesizing system was developed using polysomes and pH 5 fractions isolated from Schistosoma mansoni. Under optimal conditions, the system incorporated 35-S methionine into TCA-precipitable protein at a rate of approximately 1.8 pmoles/hr/microgram polysomal RNA. Praziquantel had no significant effect on the rate of protein synthesis, whereas hycanthone, at concentrations of 0.125 and 0.5 mM, caused a 136% and 515% stimulation, respectively. The mechanism of the stimulation is unknown. This S. mansoni--cell-free system for protein synthesis has been standardized so that new drugs can now be screened with relative ease for their effects on in vitro protein synthesis or charging of tRNA.

Animals↗