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Biomedical subjects

J Lucas

Publications and source records attributed to J Lucas.

161 records · Page 9Linked to original sources
PubMedDate not supplied

[Tocolysis with nifedipine: its use in current practice].

OBJECTIVES: To assess tocolysis with nifedipine in preterm labour during actual clinical practice in terms of efficacy and safety. PATIENTS AND METHODS: Retrospective observational study during two years including preterm labour between 26 and 33+6 weeks of amenorrhea. Preterm labour was defined by the presence of three or more uterine contractions in 10 minutes associated to cervical modifications diagnosed by vaginal sonography (length<or=25 mm). Patients were excluded if they had more than two fetuses or other gestational pathologies. Tocolysis resulted in oral taking of 30 mg of nifedipine (3x10 mg) with continuous follow-up of blood pressure. Tocolysis was modified when contractions did not disappear. Success was defined when delivery was delayed more than 48 hours. Failure was defined either by a delivery occurring in the first two days of tocolysis or when a modification of treatment was required. RESULTS: Fifty-eight patients were included, 10 of whom having a twin pregnancy. Success was obtained in 84% of patients (49/58). All of these women did not deliver during the first seven days after introduction of tocolysis. Five patients delivered in the first two days after tocolysis and four others required a change in tocolysis. Mean gestational age at delivery was 37+5 weeks and 35 weeks for single and twin pregnancies, respectively. No maternal or fetal side effects were described. DISCUSSION AND CONCLUSION: Nifedipine could be prescribed for tocolysis in actual clinical practice because it seems to have safety and excellent tolerance.

Adolescent↗
PubMedDate not supplied

Generalised granulomatous disease in a horse.

A 6-year-old gelding was referred with a 3-month history of recurrent fever, inappetance, lethargy and weight loss. On clinical examination major findings were depression, thin condition, thrombophlebitis, nodules on the scrotal skin, leukocytosis, hyperfibrinogenaemia and hyperglobulinaemia. Pleural fluid and areas of lung consolidation were seen on ultrasonographic examination of the thorax. A diagnosis of chronic respiratory disease was made. Initially there was a response to antibiotic therapy but the horse was presented 3 months later with continued weight loss, recurrent fever and multifocal skin lesions, characterised by scales, crusts and nodules, affecting the nasal bridge, jugular grooves, ventral neck, withers, scrotum, prepuce, and medial gaskins. Histological evaluation of skin biopsies indicated a granulomatous reaction. On ultrasonographic examination of the thorax multiple hypoechoic lesions consistent with granulomas were seen in both lungs. A diagnosis of generalised granulomatous disease was made. The horse was euthanased at the owner's request. On necropsy examination the main findings were multiple nodules of fibrotic granulomatous inflammation in the lung, heart, liver, gastrointestinal tract and mesenteric lymph nodes, supporting the diagnosis of generalised granulomatous disease.

Animals↗
PubMedDate not supplied

Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis.

Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A strict control of the fiber diameter in the tapered sensing zone allows high sensitivity and wide spectral range exploration from 800 to 3000 cm(-1). Then, merely in depositing the mouse liver biopsies on the fiber, this device has enable us to differentiate between tumorous and healthy tissues.

Animals↗
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Who pays the price?

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Drug Prescriptions↗
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Practice nursing.

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Humans↗
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Fine needle aspiration cytologic findings in the black thyroid syndrome.

The cytologic presentation of a case of minocycline-associated black thyroid adenoma in a 30-year-old woman is described. A nodule was discovered in the left lobe of the patient's thyroid gland, and fine needle aspiration (FNA) was performed; the nodule and adjacent thyroid were subsequently surgically removed. The cytologic findings included sparse groups of epithelial cells with prominent intracytoplasmic pigment granules. The surgical specimen was interpreted as black thyroid adenoma. This case is unusual in that the pigment had accumulated preferentially in the adenoma. In retrospect, the finding of distinctive pigment in the aspirate of the nodule suggests that the black thyroid syndrome should be considered whenever dark-brown pigment is encountered in FNA cytologic specimens from the thyroid gland.

Adenoma↗
PubMedDate not supplied

[Ultrasonography and radiocholesterol scintigraphy in the topographic diagnosis of a pheochromocytoma (author's transl)].

Topographic diagnosis of adrenal pheochromocytoma were determined by ultrasonography in all 6 cases studied and by radiocholesterol scintigraphy in 6 out of 7 cases studied. It would appear that ultrasonography is preferable in the localization of an abdominal pheochromocytoma, whether adrenal or extra-adrenal. Intravenous urography along with rapid sequence nephrotomography and radiocholesterol scintigraphy, play a complementary role in confirming the topographic diagnosis. In case these methods prove unsuccessful or provide conflicting results, it is then possible to consider computed tomography, angiography and caval catheterization.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Portal hypertension thermographic aspects (author's transl)].

From the study of 80 patients, the authors show the interest of abdominal thermography to explore a portal hypertension. Linear stripes, stellar pictures, periumbilical hot spot are specific pictures. These thermographic modifications come before cutaneous venous signs in half of the population. Their interest for prognosis remains to be specified.

Humans↗