The authors report two cases of FSH secreting adenomas in men and attempt to draw out some features of these very uncommon pituitary tumors. Absence of gynecomastia is emphasized. Diagnosis proceeds from systematic radio-immunoassay of pituitary hormones. Evidence of FSH secretion results from paradoxical gonadotropin stimulation by TRH and secretory granules seen by electronic microscope. Immunofluorescence studies are still to perform. Dynamic testicular secretion and, in one case, histologic examination were performed.

Adenoma↗

PubMedDate not supplied

Isolated pseudotumoural sarcoidosis of the hypothalamic-pituitary area.

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Diagnosis, Differential↗

PubMedDate not supplied

Serum LpAI lipoprotein particles in diabetic patients with and without renal lesions of different grades.

Among high density lipoprotein particles, LpAI particles which contain apolipoprotein A1 alone, appear to be involved in cholesterol transport from peripheral tissues to the liver. The aim of this cross-sectional study was to examine serum LpAI particle concentrations in Type 1 and Type 2 diabetic patients with renal lesions of differing grades, in comparison with normal controls and with nondiabetic patients presenting with chronic renal failure. LpAI concentrations and LpAI-to-apo A1 ratios were increased in Type 1 diabetic patients with normal albumin excretion. In Type 1 and in Type 2 diabetic patients with increased urinary albumin excretion, LpAI concentrations and LpAI-to-apo A1 ratios were found to be not different from those of normal controls. In diabetic and in nondiabetic patients with chronic renal failure, LpAI concentrations were decreased. These abnormalities may contribute to the development of macrovascular complications.

Adult↗

PubMedDate not supplied

[Multiple complications of treatment with perhexiline maleate].

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Aged↗

PubMedDate not supplied

[A phonomecanographic test of hyperthyroidism].

Systolic intervals may be studied by phonomechanography. This provides data regarding the function of the left ventricle. In the absence of any problem of intraventricular conduction or valvular lesion, such information is particularly valuable. Thyroxine impregnation, whetHer active directly and/or by catecholamine hypersecretion, results in cardiac hyperkinesia which is reflected not only by tachycardia but also a shortening penetration time and contraction of the ventricular muscle. This shows itself within systole as a change in the relation between the duration of the pre-ejection phase (PPE) and the ejection phase. The first decreases whilst the second remains normal and their ratio changes, PPE/E changes from a normal value of 0.34 +/- 0.04 to 0.25 +/- 0.03. These tests are not only of value in diagnosis but also make it possible to observe the effects of treatment. It is certain that a true phonomechanographic syndrome of cardiac hyperkinesia may be described. The commonest, though not the only, aetiology is hyperthyroidism.

Electrocardiography↗