The transforming genes of acutely transforming retroviruses are derived from conserved cellular genes (c-onc genes) which are believed to be important in normal cell growth and differentiation. Recent studies indicate that altered expression of c-onc genes, for example, by insertion of viral genomes, gene amplification or chromosomal translocation, can lead to development of malignant diseases in man and animals. c-myb and c-fes are homologues of the transforming genes of avian myeloblastosis virus and feline sarcoma virus (Gardner and Snyder-Theilen strains), respectively. c-myb is transcribed preferentially in immature haematopoietic cells and probably codes for a protein important in differentiation of these cells. The viral fes gene, like several other viral onc genes, encodes a tyrosine-specific protein kinase. However, c-fes transcripts have not been detected in the types of human cells examined so far. c-myb and c-fes have been assigned to human chromosomes 6 and 15, respectively. Specific aberrations involving these chromosomes have been observed at high frequency in several human neoplasms. We have now sublocalized c-myb to 6q22-24 and c-fes to 15q25-26 by in situ hybridization of the human c-onc probes to human mitotic chromosome preparations. These chromosomal segments are indeed involved in nonrandom translocations in several human tumours. The results encourage further investigation into the role of onc genes in the pathogenesis of specific neoplasms.

Chromosome Aberrations↗

PubMedDate not supplied

Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution.

DXYS1, a site showing greater than 99% DNA sequence homology between the human X and Y chromosomes, maps to the X long arm and to the Y short arm. In great apes, sequences homologous to DXYS1 are found only on the X chromosome. These findings suggest an X-Y transposition during human evolution.

Animals↗

PubMedDate not supplied

Paraplegia following intra-aortic balloon support. Report of a case.

A case is presented of paraplegia associated with the intra-aortic balloon pump used in a post-operative patient. The published experience with this complication is reviewed.

Adult↗

PubMedDate not supplied

Use of power spectral density analysis for the evaluation of artificial heart valves.

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Biomedical Engineering↗