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Biomedical subjects

J Lopez

Publications and source records attributed to J Lopez.

At least 145 records · Page 8Linked to original sources
PubMed1981

The early detection of the effects of surgical shock on the viscera.

One hundred and one patients, in shock after operations were reviewed to examine the visceral effects on their prognoses. The shock was caused in 65 cases by hypovolaemia and in 36 cases by sepsis. The effects were studied on the heart and cardiovascular system, liver, kidneys, gastrointestinal system, central nervous system, lungs and blood clotting system. Surgical shock affected more frequently the lung and liver (P less than 0.05 and P less than 0.01). The lungs were most frequently involved in hypovolaemia (25 patients) and sepsis (25 cases). Pathology of the lung was associated with the highest mortality rate (P less than 0.005), followed by kidney (P less than 0.01) then heart and central nervous system (P less than 0.025). Involvement of the gastrointestinal tract or clotting system alone was not associated with higher mortality rates, except in the presence of other visceral derangements. Lung affection also had a greater mortality followed by kidney and the central nervous system. Involvement of one or several organs in failure to survive septic shock is dealt with in the discussion. It is concluded that visceral involvement secondary to shock could be of importance for prognosis.

Adolescent↗
PubMed1981

The Raman spectra of selenomethionine and selenocystine.

The trace element selenium is known to be a part of the enzyme glutathione peroxidase (glutathione-hydrogen peroxide oxidoreductase, E.C.1.11.1.9). Studies have shown that selenium in the enzyme exists in at least two forms or oxidation states. It is probable that selenium has been incorporated into the enzyme as the selenocysteine amino acid. In the present study, the Raman spectra of selenocystine and selenomethionine have been obtained, structural assignments have been verified, and the behavior of the two selenoamino acids have been monitored under varying conditions of oxidative stress. The assignments will assist in the interpretation of the spectrum of the actual enzyme.

Cysteine↗
PubMed1981

Multiple forms of growth hormone: detection in medium from cultured pituitary adenoma explants.

Three pituitary adenomas obtained from patients wtih acromegaly were maintained in organ explant culture for a period of 12 days in a defined culture medium. Lyophilized culture medium from each was then examined by electrophoresis to determine which forms of growth hormone were secreted by the explants. All three explants secreted principally the major form of growth hormone. One adenoma however secreted unusually large amounts of two slowly migrating forms which were in low concentration in the GH-containing granules of normal pituitaries. On the other hand the adenoma produced a much lower amount of a 20,000-dalton variant than was seen in normal pituitary glands. The other two adenomas did not secrete the relatively large amounts of the slowly migrating forms although the quantity of the 20,000-dalton form was less than the amount seen in the normal pituitary. There was no evidence of proteolytic alteration of the growth hormone during the culturing process. In companion experiments with rat pituitary glands the growth hormone did not undergo proteolytic degradation in the gland left in situ for 96 h at 5 degrees C.

Adenoma↗
PubMed1981

Rotavirus infection in children with acute gastroenteritis in Ecuador.

Electron microscopic examination of stools of 702 infants and young children hospitalized in the Emergency Service of the Alejandro Mann Children's Hospital in Guayaquil, Ecuador, between August 1978 and October 1979 showed rotavirus to be present in 148 (21.1%). During the study period rotavirus was detected throughout the year, with no distinct seasonal variation. In addition to rotavirus, adenovirus was detected in stools of five (0.7%) of the patients and unidentified small round virus particles in seven (1.0%).

Acute Disease↗
PubMed1979

Esophageal achalasia after maxillofacial surgery.

An unusual, characteristic case of etiopathic achalasia of the esophagus is reported and the literature is reviewed. This disease has not previously been reported in the dental literature, but is well-known in the medical field. The case report illustrates the salient features of previosuly described achalasia in adults: vague history of asthma with respiratory symptoms of wheezing, obstruction to swallowing, regurgitation, intermittent pain, and peripheral neuritis in a thin patient who claims to be a light eater. The primary concern of the oral surgeon is the management of nutrition. In the case reported, to ingest food. After mobilization of the jaws, the patient could not longer eat the small amounts she could preoperatively. Suspected achalasiactic symptoms should be investigated thoroughly through proper work-up to rule out this disorder before elective surgery is performed. In nonelective cases, the practitioner must be prepared to manage the problems and complications and obtain the proper consultations.

Adult↗
PubMed1979

The gastric microenvironment in populations at high risk to stomach cancer.

The gastric juice of patients with atrophic gastritis from the high-risk gastric cancer region of Nariño, Colombia, was analyzed for nitrate, nitrite, and thiocyanate content. Patients whose gastric juice pH is greater than 5 have significant elevation of nitrite values. The possible role of nitrite in gastric carcinogenesis is discussed.

Adult↗
PubMed1978

Surgical management of microstomia in the dental office.

Scarring of the oral stoma is usually a consequence of burns of the circumoral region. The subsequent contractural decrease in the width and general size of the opening is deforming, interferes with eating, makes dental treatment extremely difficult, prevents access for oral hygiene, and makes general anesthesia hazardous. A case report demonstrates the relative ease and safety of performing a commissurotomy in the dental office with local anesthesia alone so that access is facilitated and the dentition of these patients can be rehabilitated.

Adult↗