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Biomedical subjects

J Long

Publications and source records attributed to J Long.

At least 109 records · Page 6Linked to original sources
PubMed1991

[Cerebellar infarction and its assistant examination].

The clinical manifestations of cerebellar infarction are often non-particular and it is difficult to make such a diagnosis clinically. Diagnosis was based on pathology previously. Most of the cases were overlooked while still living and the true morbidity was not known. CT scan has made the diagnosis of this disease possible clinically in some patients, but CT is still not an ideal instrument for diagnosing this disease because of the interference by bony artifacts of posterior fossa. The advent of MRI made it possible to distinguish cerebellar infarction safely and easily. It is not the most powerful tool for diagnosing this disease. The authors reported 15 cases of cerebellar infarction diagnosed by clinical manifestation, neuroimages and pathology and pointed out that further knowledge of this disease is needed.

Adult↗
PubMed1990

[Non-operation management of 12 cases with brain abscess demonstrated by CT scan].

This paper reported 12 cases with brain abscess demonstrated by CT scan. Using antibiotic management without surgical intervention, in 10 cases the curative effects were satisfactory. The paper indicated that CT scan was very useful in prompt and correct diagnosis of brain abscess and with sequential CT scan medical therapy was feasible. It is significant in treatment of brain abscess especially for the patients who have a poor general condition, have the brain abscess located in important functional area or have multiple abscesses so that the operation is difficult for them.

Adolescent↗
PubMed1989

Splenosis masquerading as small bowel neoplasm.

Incidental discovery of a mass during laparoscopic surgery resulted in exploratory laparotomy for a young woman. The mass' uncharacteristic appearance belied its true identity as displaced splenic tissue. The authors suggest ways to identify splenosis without resorting to further surgery.

Adult↗
PubMed1988

Conjugation of monoclonal antibodies to a synthetic peptide substrate for protein kinase: a method for labelling antibodies with 32P.

In recent years, radiolabelled monoclonal antibodies have been evaluated for their use in the diagnosis and treatment of neoplastic disease. One isotope which has not been assessed for antibody targeting is 32P, even though it has many favourable radiobiological characteristics and has been used clinically for the treatment of certain neoplastic disorders such as polycythaemia rubra vera. The main drawback so far in using 32P has been the absence of a general method for phosphorylating antibodies. We have now developed a novel process for the phosphorylation of immunoglobulins which is rapid, efficient and allows high specific activities to be achieved (greater than 10 muCi micrograms-1). The technique involves the chemical conjugation of Kemptide, a synthetic heptapeptide substrate for kinases, to immunoglobulins. The antibody-Kemptide conjugate can then be phosphorylated using protein kinases and [32P]-gamma-ATP. The procedure does not compromise the binding activity of the antibody. The 32P-labelled monoclonal antibodies were stable in human, mouse and rat plasmas in vitro, although they cleared from the bloodstream of mice with a beta-phase half life of 2 days which is approximately two times faster than that of native antibody. The application of this phosphorylation technique should allow the therapeutic potential of targeted 32P to be assessed.

Animals↗
PubMed1985

Why families change pediatricians. Factors causing dissatisfaction with pediatric care.

Dissatisfaction with their child's physician sometimes causes parents to transfer to a new provider. We studied the reasons for such transfers from four pediatric practices in Chittenden County, Vermont. Personal qualities of the physician, including the parent's perception of the physician's communication skills, his or her clinical competence, and the apparent level of concern were the most important factors that distinguished satisfied from dissatisfied parents. Structural features, including costs, waiting time, and continuity with the same physician, were less often sources of enough dissatisfaction to produce a transfer. Effectiveness and success in pediatric practice are dependent on competence, communication, and caring.

Appointments and Schedules↗
PubMed1984

"Serious drinking," "white man's drinking" and "teetotaling": drinking levels and styles in an urban American Indian population.

The differences between abstainers, moderate drinkers and heavy drinkers were examined in American Indians living in Los Angeles, California. Equal numbers of these three groups (total N = 155) were selected from four tribal groups: Siouan-speaking, Navaho, Five Civilized Tribes (of eastern Oklahoma origin) and indigenous California tribes. The relative predictive powers of sociostructural, cultural and psychological variables in accounting for current drinking levels were then assessed. The results indicated that, much as for non-Indian populations, heavy drinkers were more likely to have had heavy-drinking models in the family of origin, to be men and to score high on psychophysiological stress indices. Socioeconomic status and traditionalism were found to be weaker predictors of drinking level. Differences in drinking styles over individuals' lifetimes and between tribes were also studied. Ethnographic observations, case vignettes and statistical summaries of the sample by tribe and by drinking level showed that tribal origins, age and socioeconomic status influenced drinking style and attitudes toward alcohol, even if they did not predict the current drinking level of the subjects.

Adult↗
PubMed1984

Urban and rural Indian drinking patterns: implications for intervention policy development.

Alcohol misuse has taken on epidemic proportions among some (but not all) American Indian populations. Cultural, psychological, socioeconomic and genetic etiologies have been offered to explain this social phenomenon. This study identifies the relative strengths of these causal models to differentiate among both current and lifelong drinking career patterns. Further, antecedent and drinking level differences between urban and rural Indian populations in California are described. Age, sex, level of stress as measured by the Cornell Medical Index, percent of Indian ancestry and level of drinking in the family of origin are less powerful predictors of drinking level. Policy implications of these findings include: the development of intervention programs which involve members of the patient's support network, accelerated interventions in rural Indian communities and mid-level interventions among younger and less debilitated, but identifiably "at risk", populations.

Adolescent↗