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Biomedical subjects

J Lohmann

Publications and source records attributed to J Lohmann.

31 records · Page 2Linked to original sources
PubMed1983

Drug intoxication: influence of hemoperfusion on human plasma fibronectin.

Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. Patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. Charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.

Adolescent↗
PubMed1983

[Treatment of acute liver failure by plasmapheresis].

Repeated plasmaphereses were done in 7 patients with acute hepatic failure (5 of them with coma stage IV and two with stage III). Acute liver insufficiency was induced by fulminant viral hepatitis in 4 cases, by drugs in one case, and was caused by a dystrophic exacerbation of liver cirrhosis in two further cases. Four of the 7 treated patients have survived. Beginning improvement of hepatic function was evidenced by an increase of factor VII and prothrombin in plasma. Significant lowering of bilirubin could be observed in all cases. While ammonia values decreased continuously in the four successfully treated patients while on plasmapheresis, the opposite behaviour was observed in the decreased patients. The influence of plasmapheresis on the pathologically altered aminoacid pattern in hepatic coma was investigated in two patients: Before treatment clearly to excessively increased values of methionine and aromatic aminoacids (phenylalanine and tyrosine) were seen. Branched-chain aminoacids leucine, isoleucine and valine were normal to moderately decreased. After termination of plasmapheresis methionine and aromatic aminoacids were significantly lower, branched-chain aminoacids were slightly below the initial values. Improvement of consciousness correlated with increase of the quotient (val+leu+ile)/(phe+tyr).

Acute Disease↗
PubMed1983

[Guillain-Barré polyradiculitis in acute viral hepatitis type B--case report].

A polyneuritis of the Guillain-Barré type developed in a 29 year-old female patient during the icteric stage of viral hepatitis B. The main symptoms were diffuse paresthesias and increasing motor weakness of the limbs, ending up in paralysis of the legs. The analysis of the CSF (albumin raised, cell count normal) and electroneurographic findings were diagnostically reaffirming. The patient was given prednisolone. All symptoms disappeared within two months.

Acute Disease↗
PubMed1982

Plasma fibronectin in man after a severe paraquat intoxication.

Fibronectin is a cell surface glycoprotein and belongs to the opsonic system. It can be easily determined in human plasma by laser nephelometry. Patients in shock or with septicemia have extremely low concentrations of fibronectin in plasma which seems to correlate with a depression of the reticuloendothelial system (RES). Determination of fibronectin in human plasma may be a useful parameter for monitoring RES function. Severe intoxication with Paraquat causes a reduction of fibronectin and possibly influences RES function as well.

Adult↗
PubMed1982

Successful treatment of paraquat poisoning: activated charcoal per os and "continuous hemoperfusion".

Ingestion of paraquat results in an extremely dangerous poisoning. The first aim is to clear the gastrointestinal tract by inducing emesis and performing gastric/gut lavage; as much activated charcoal as possible should be administered per os and as quickly as possible. The best measure to eliminate paraquat from blood and tissue is hemoperfusion with coated activated charcoal; it has to be performed in the sense of "continuous hemoperfusion" about 8 h/d over a period of 2-3 weeks. These measures give a chance to lower the lethality of paraquat poisoning.

Adolescent↗
PubMed1981

[Reduced plasma fibronectin in patients with sepsis and shock (author's transl)].

Plasma fibronectin concentrations were determined in 16 patients with sepsis and shock. In all patients a definite decrease was observed during the course of the disease which did not correlate with coagulative function. Fibronectin in plasma rose to normal levels with improvement in the clinical picture. It is possible that plasma fibronectin indicates the functioning of the reticuloendothelial system.

Adult↗
PubMed1976

[Disturbances in the regulation of phospholipid metabolism of the whole liver, mitochondria and microsomes in acute thioacetamide poisoning and the influcence of silymarin].

In the whole liver of rats, pretreated with 4% polyvinylpyrrolidone solution, 24 h after i.p. application of 300 mg thioacetamide/kg body weight, an increase of total lipids, triglycerides and phospholipids is observed, in the mitochondrial fraction phospholipid concentrations are decreased. At the same time, phosphatidylcholine/phosphatidyl-ethanolamine ratio is diminished in mitochondrial and microsomal fraction. After administration of [l-14C]-palmitate, in comparison with non-intoxicated animals, a statistically significant reduction of specific radioactivity of phosphatidylethanolamine could be observed in microsomal and mitochondrial fraction; specific radioactivities of total lipids, total phospholipids and phosphatidyl choline trend to diminution in the whole liver and in subcellular fractions. By prophylactic i.p. application of silymarin-N-methylglucamine salt (400 mg/kg body weight), dissolved in 4% polyvinylpyrrolidone solution, there is a normalization of altered microsomal phosphatidylcholine/phosphatidylethanolamine ratio as well as an enhancement of diminished mitochondrial phosphatidylcholine concentration, while the reduction of specific radioactivities of phosphatidylethanolamine is partially abolished in the mitochondrial fraction.

Acetamides↗
PubMed1975

[The effect of silybin-dihemisuccinate on regulation disorders in phospholipid metabolism in acute galactosamine intoxication in the rat].

1. 24 h after application of 900 mg D-galactosamine/kg body weight, an increase of total lipids, triglycerides, phosphatidyl-choline and phosphatidic acid concentrations, and also a decrease of total phospholipids and phosphatidylethanolamine can be determined in the whole rat liver. After administration of [1-14C]-palmitate, specific radioactivity of phosphatidyl-choline is diminished without alteration of specific radioactivity of other lipid fractions. Prophylactic application of silybin-dihemisuccinate abolished completely decrease of phosphatidyl-ethanolamine and diminished increase of total lipids and triglyceride concentrations. 2. Specific radioactivity of total lipids in serum of galactosamine-intoxicated rats is enhanced, specific radioactivity of triglycerides and phospholipids is diminished, simultaneously, total lipids concentration is reduced. 3. In the microsomal fraction of galactosamine-injured livers, a decrease of specific radioactivity of total phospholipids and phosphatidyl-choline can be observed. Prophylactic administration of silybin abolishes diminution of specific radioactivity of phosphatidyl-choline partially. 4. Diminution of specific radioactivity of total lipids, total phospholipids and phosphatidyl-ethanolamine, induced by galactosamine intoxication in the mitochondrial fraction, is normalized by application of silybin. 5. Diminished triglyceride infiltration in siybin-treated rats may be based onnormalization of inhibited phosphatidyl-choline turnover.

Animals↗
PubMedDate not supplied

[Laminin P1 and procollagen III peptide in serum: activity parameters in chronic inflammatory joint diseases].

Chronic inflammatory arthritis causes progressive destruction of the joints. Non-specific parameters of inflammation are used in controls, because specific tests are not yet available. In this study, we determined parameters of connective tissue metabolism in 215 sera of patients with chronic inflammatory arthritis, since morphological changes in synovial tissue in these diseases are characterized by proliferation of mesenchymal cells and extracellular matrix. Serum concentration of procollagen-III-peptide (P-III-P) was increased in patients with a markedly progressive disease. Fragment P1 of the basement membrane component laminin was found to be enhanced in the serum of all groups of patients - even in the early stages of diseases. In addition, follow-up over 2 years showed a good correlation between the progression of the diseases and the serum concentration of the two parameters. Our results indicate that P-III-P and laminin P1 serum content specifically reflect the proliferation of mesenchymal tissue in rheumatic diseases of the joints. Determination of both parameters may therefore be useful in estimating the progression of the disease and the benefit of treatment.

Adolescent↗