Biomedical subjects

J Linseisen

Publications and source records attributed to J Linseisen.

18 recordsLinked to original sources

PubMed2000

Antioxidant status of surgical patients receiving TPN with an omega-3-fatty acid-containing lipid emulsion supplemented with alpha-tocopherol.

BACKGROUND: LCT lipid emulsions and even more fish oil-containing lipid emulsions are under debate regarding their tocopherol and PUFA content as well as their effect on the antioxidative status especially in patients with oxidative stress. METHODS: Thirty-three patients undergoing major abdominal surgery were randomly assigned to receive either an alpha-tocopherol-supplemented (562 micromol/l) MCT/LCT/omega-3-acid triglycerides (MLF, 5/4/1 w/w/w, 20%) emulsion or a soybean oil-based LCT emulsion (20%). The TPN regimen continuously provided 1.4 g fat kg bw(-1)d(-1)over 5 days. RESULTS: Plasma antioxidant concentrations were strongly reduced by surgical treatment. Following 5 days of TPN with the MLF emulsion, mean plasma alpha-tocopherol increased by 20.0 micromol/l (1.98 micromol/mmol lipid), while nearly no change was observed in the LCT emulsion group. In both groups, plasma concentrations of all non-supplemented antioxidants (vitamin C, carotenoids, selenium) as well as serum total antioxidant capacity further decreased during TPN. The concentrations of plasma cholesterol oxidation products as a measure of in vivo lipid peroxidation revealed no changes over the TPN period in either group. CONCLUSION: In contrast to the LCT emulsion, administration of the a-tocopherol supplemented MLF lipid emulsion normalized a-tocopherol plasma concentrations. Despite its high long-chain PUFA content, no hint for increased lipid peroxidation was found.

Abdomen↗

PubMed1999

Acute effects of LDL-apheresis on cholesterol oxidation products and antioxidants in plasma and lipoproteins of patients with familial hypercholesterolemia.

Regular LDL-apheresis treatment of hypercholesterolemic patients has proven to reduce the formation of atherosclerotic lesions. Regarding the underlying mechanisms, cholesterol oxidation products (COP) may play a detrimental role. Therefore, COP levels were determined before and after regular LDL-apheresis treatment in ten patients with familial hypercholesterolemia. - The patients had approximately twofold elevated plasma and LDL COP concentrations on the average as compared to healthy subjects. LDL-apheresis treatment efficiently removed COP from the circulation. As a consequence of a smaller reduction of the COP content (- 52 %) than of the total cholesterol content (-71 %) in LDL, the LDL COP:cholesterol ratio increased. Lipid-soluble antioxidants in the plasma of the hypercholesterolemics decreased to a comparable extent as did plasma lipids. In contrast to nearly stable vitamin C concentrations, plasma selenium concentrations also decreased, resulting altogether in a decreased but still normal serum total antioxidant capacity. - In conclusion, LDL-apheresis treatment effectively reduced potentially atherogenic COP from the plasma. With normal plasma antioxidant concentrations before LDL-apheresis in long-term treated hypercholesterolemics, the observed acute decrease in lipid-soluble antioxidants and selenium by treatment seems not to be as meaningful. The higher LDL COP:cholesterol ratio after treatment needs further elucidation.

Adolescent↗

PubMed1999

Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans.

BACKGROUND: Antioxidant concentrations in low density lipoproteins (LDL) are an important determinant for their susceptibility to oxidation and can be modulated by dietary intake. AIM OF THE STUDY: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated. METHOD: An antioxidant supplement consisting of beta-carotene, lycopene, lutein, canthaxanthin and alpha-tocopherol was given to six young women together with a standard meal. Using a cross-over study design, each subject received the standard meal without additional dietary fiber and enriched with pectin, guar, or cellulose in a random order. To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured. RESULTS: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase. Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without. On average, pectin, guar, and cellulose reduced the increase of the lag phase (measured without addition of dietary fiber) by 38%, 22%, and 18%, respectively. CONCLUSIONS: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and alpha-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.

Adult↗

PubMed1999

Some dietary fibers reduce the absorption of carotenoids in women.

Dietary fiber may be partly responsible for the lower bioavailability of carotenoids from food than from purified supplements. Due to the lack of detailed information available, we investigated the effects of different kinds of dietary fiber on the absorption of carotenoids and alpha-tocopherol. Six healthy young women received an antioxidant mixture consisting of beta-carotene, lycopene, lutein, canthaxanthin and alpha-tocopherol together with a standard meal. The meal did not contain additional dietary fiber or was enriched with pectin, guar, alginate, cellulose or wheat bran (0. 15 g. kg body weight(-1)). The increases in plasma carotenoid and alpha-tocopherol concentrations were followed over 24 h, and the areas-under-curves (AUC(24h)) were calculated. The mean AUC(24h) of beta-carotene was significantly (P < 0.05) reduced by the water-soluble fibers pectin, guar and alginate with a mean decrease of 33-43%. All tested fibers significantly reduced the AUC(24h) of lycopene and lutein by 40-74% (P < 0.05). The dietary fiber effect on the AUC(24h) of canthaxanthin was almost significant (P = 0.059) and there was no effect on the AUC(24h) of alpha-tocopherol. We conclude that the bioavailability of beta-carotene, lycopene and lutein given within a mixed supplement is markedly reduced by different kinds of dietary fiber.

Absorption↗

PubMed1998

Effect of a single oral dose of antioxidant mixture (vitamin E, carotenoids) on the formation of cholesterol oxidation products after ex vivo LDL oxidation in humans.

During oxidation of LDL not only polyunsaturated fatty acids and apolipoproteins but also cholesterol is affected. To test the preventive effect of vitamin E and carotenoids against metal ion-induced oxidative modification of the cholesterol moiety, LDL of five females (age 25-30 years) were enriched by single oral supplementation with a mixture of alpha-tocopherol, beta-carotene, lycopene, canthaxanthin, and lutein. LDL was isolated from blood samples before as well as 10 and 24 hours after supplement intake. In the 10 and 24 hours samples, total concentration of the supplemented antioxidants increased significantly to 127% and 125% of the initial value, respectively. As a consequence, the lag phase until beginning of oxidative modification of fatty acids--measured in terms of lag phase time till diene production--significantly increased by 13% (10 h and 24 h). After stopping the oxidation process in all LDL samples (0 h, 10 h, 24 h) of one person when the maximal absorbance value of diene production in the 10 h sample was reached, a statistically significant reduction in the formation of cholesterol oxidation products (COP) could be measured. In the average, 10 h and 24 h after supplementation the COP concentration reached 84% and 86% of the 0 h-value, respectively. Except for 7 beta-hydroxycholesterol, all COP measured decreased by 10-20%. The results of the in vitro-model demonstrate that an antioxidant enrichment of LDL has the potential to protect also cholesterol (besides unsaturated fatty acids) against oxidative modification.

Administration, Oral↗

PubMed1998

[Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey].

Phenolic acids, essentially hydroxycinnamic acids and hydroxybenzoic acids, are secondary plant products and commonly found in plant derived foodstuff. The antioxidant and anticarcinogenic properties of phenolic acids could be one of the facts to explain the inverse association between fruit and vegetable intake and the incidence of coronary heart disease and cancer, respectively, as found in epidemiologic studies. Phenolic acids are rarely listed in food composition tables and there are no dietary intake data available. Consequently, a data base containing the phenolic acid content of foods (literatur data) was built and 7-d dietary protocols of 63 women and 56 men of a Bavarian subpopulation (age 19-49 years) of the German National Food Consumption Survey (NVS) were evaluated. The average phenolic acid intake of men and women is 222 mg/d within a large range. The dominating one within all the phenolic acids is clearly caffeic acid (206 mg/d); the intake of the other phenolic acids amounts to 0.2 (gentisic acid) up to 5.2 mg/d (ellagic acid). The sum of hydroxybenzoic acids and hydroxycinnamic acids amounts to 11 mg/d and 211 mg/d, respectively. Significant sex differences are found for some of the phenolic acids. Especially, the average intake of caffeic acid of women (229 mg/d) is higher than that of men (179 mg/d) caused by the high amount of coffee consumption. The age group "25-49 years" is consuming more coffee than the age group "19-24 years" and, therefore, reveals a significantly higher intake of caffeic acid. The major sources of phenolic acids are coffee with 92% of the caffeic acid intake and fruits (including fruit products and juices) with 75% of the salycilic acid and 59% of the p-coumaric acid intake. Consequently, phenolic acids are consumed in considerable amounts with food. Since antioxidant and anticarcinogenic properties of phenolic acids are already proven in in vitro as well as in animal experiments, epidemiologic studies will show whether a high phenolic acid intake goes ahead with a reduced risk for coronary heart disease or cancer in humans.

Acids, Carbocyclic↗

PubMed1998

Sucrose intake in Germany.

The present investigation reevaluated the German National Food Consumption Survey in order to obtain data on sucrose intake and food sources of sucrose intake in Germany. Moreover, it focused on the effect of sucrose intake on nutrient intake. By means of the food composition data base Bundeslebensmittelschlüssel, version II.2, 7-days dietary records of a representative sample of 15,838 persons aged 4 years and older were analyzed. The relation between sucrose and nutrients intake was investigated by variance and regression analyses. Low, moderate, and high sucrose intake categories were defined by means of sucrose density quartiles and comparisons were made for the percentages of persons meeting the German nutrient intake recommendations. Mean daily sucrose intake ranges between 43.2 g/d (f, 51-64 years) and 82.3 g/d (m, 13-14 years). The mean contribution of sucrose to total energy intake is highest with 14% in young age (4-6 years) and decreases to 9% and 7% in 51-64 year old women and men, respectively. The food groups "table sugar", "confectionery and ice cream", "biscuits, cake and pastries", "preserves", "dairy products", and "non-alcoholic beverages" are the main sucrose sources with varying importance in different age groups. The average amount of naturally occurring sucrose in the Germans' diet is estimated to 15-25% of total sucrose intake. Sucrose contributes 80-90% to total disaccharides intake in Germany. With each gram of sucrose the intake of energy rises on the average by 12.5 kcal (52.4 kJ), of protein by 0.3 g (9% of the energy increase), of fat by 0.5 g (34%), and of carbohydrates by 1.8 g (57%). Consequently, the higher the sucrose content of a diet, the lower is the contribution of fat to total energy intake. In contrast, the energy-adjusted effect of sucrose was found to be negative for energy-providing nutrients (except mono- and disaccharides) as well as for all the selected micronutrients, except calcium, vitamin E, vitamin C, and dietary fiber. Accordingly, the comparison between moderate and high sucrose consumers revealed a lower percentage of persons meeting nutrient intake recommendations in the high sucrose category under the condition of a comparable energy intake. This unfavorable effect of high sucrose intake is most prominent in 4-6 year old boys and girls as the groups with the highest sucrose intake. Since from the present data no exact figure for a sucrose or sugars intake recommendation can be deduced, it is suggested to keep on the WHO recommendation for a moderate sugar intake of 10% of energy intake.

Adolescent↗

PubMed1998

Absorption of cholesterol oxidation products from ordinary foodstuff in humans.

BACKGROUND: Information on the absorption of cholesterol oxidation products (COP) from ordinary foodstuff in humans is scarce. METHODS: Five healthy young men were offered a salami- and Parmesan-containing meal naturally rich in COP. Plasma and lipoprotein COP concentrations were measured over the following 9 h. RESULTS: The mean plasma free (nonesterified) COP concentration showed its maximal increase 3 and 5 h after meal consumption. In contrast, the raise in plasma total COP concentration began 6 h after the meal with a maximum at 8 h and was statistically significant for 7alpha- and 7beta-hydroxycholesterol and 7-ketocholesterol. The increase in plasma total cholesterol concentration was comparable to that of total COP. Comparing the COP composition of the chylomicrons and the test meal, cholestanetriol, 7-ketocholesterol, and to a lesser extent cholesterol-alpha-epoxide were underrepresented in the chylomicrons as was the opposite for 7beta-hydroxycholesterol. In very-low-density lipoprotein, a steady increase in the COP:cholesterol ratio was observed from 6 h on. CONCLUSION: COP from ordinary foodstuff were absorbed in the human intestinal tract but differences in the bioavailability of the single COP compounds were found.

Absorption↗

PubMed1997

[Differences in nutrient intake using different nutrient databases-- an example].

Mean dietary intake calculated from 25 7-day-food records by means of the three nutrient data bases modified Souci/Fachmann/Kraut (mSFK) 1986/87, extract of Bundeslebensmittelschlüssel (BLS) version 2.1, and extract of BLS version 2.2 revealed comparable results only for four of 27 nutrients considered. The greatest deviations were found for zink, fluoride, iodine, vitamin D, vitamin C, and dietary fiber. Comparing the revised BLS version 2.2 and mSFK, the differences in fluoride, iodine and dietary fiber intake data were markedly lower than found with the comparison of BLS 2.1 and mSFK; statistically significant differences no longer existed for the vitamins C and A (equivalents). As expected, using the mSFK data base with some missing fields for analytical data underestimation of nutrient intake could be shown for the trace elements zink, fluoride and iodine. With regard to the given results of the investigated group, care has to be taken with some nutrient intake data gathered by means of BLS 2.1, too.

Diet Records↗

PubMed1997

[Flavonoid intake of adults in a Bavarian subgroup of the national food consumption survey].

Flavonoids as naturally occurring compounds of plant derived foodstuff reveal some biological effects (antioxidative, antimutagenic, anticarcinogenic) which makes them interesting substances in the prevention of atherosclerosis and cancer in humans. Data on the flavonoid content of food are not considered in food composition tables, and human intake data are scarce (flavonols) or missing. Consequently, after installing a flavonoid data base by means of literature data, 7-d dietary protocols of 119 adults (63 women and 56 men, age 19-49 years) representing a bavarian subgroup of the German National Food Consumption Survey (NVS) were evaluated. In all subjects, average intake of all flavonoids (calculated as aglycons) amounts to 54.0 mg/d (median) with a great range of variability. The most important flavonoid groups are flavonols (12.0 mg/d), catechins (8.3 mg/d), and flavanons (13.2 mg/d), followed by anthocyanidins (2.7 mg/d), proanthocyanins (3.7 mg/d) and phloretin (dihydrochalcone) (0.7 mg/d). Sex differences did not reach statistical significance. Fruits, fruit products and fruit juices were the most important flavonoid sources. Vegetables and its products provided about half of the flavonol intake. Therefore, statistically significant correlations (p < 0.001) exist between total flavonoid intake and the intake of vitamin C (r = 0.59) or dietary fiber (r = 0.49). Compared to other countries, flavonol intake of the investigated group of persons is rather low. With the built data base it was possible for the first time to calculate the intake of further flavonoids besides flavonols. In comparison to the intake of other antioxidants (e.g. vitamins C and E) the amount of flavonoids in the diet is considerably high and therefore should be regarded in further investigations on the role of diet in certain diseases.

Adult↗

PubMed1996

Influence of knowledge on iodine content in foodstuffs and prophylactic usage of iodized salt on urinary iodine excretion and thyroid volume of adults in southern Germany.

Thyroid volume, urinary iodine excretion as well as personal nutritional knowledge and individual iodine prophylaxis were determined during a health education program on iodine deficiency and prophylaxis in 1992. Participants were 472 male and 568 female (mean age 27.7 years) students and employees of five universities in the southern part of Germany. The study aimed to clarify the relationship between personal knowledge on iodine, individual iodine prophylaxis and parameters of iodine deficiency (thyroid volume, iodine excretion) in a well known iodine deficient area. Mean thyroid volume (mean +/- SD) was 19.7 +/- 8.3 ml in males and 15.8 +/- 7.1 ml in females. 25.5% of females and 19.9% of males showed thyroid volume above the upper normal values. Total mean urinary iodine excretion was 70.7 +/- 42 micrograms I/g creatinine reflecting WHO-grade-I iodine deficiency. 80.8% of total subjects used iodized salt and 43.2% stated to consume salt-water fish to meet their iodine requirement. The female non-users had significantly lower iodine excretion (no iodized salt, no salt-water fish: 61.4 +/- 31.3 vs. +iodized salt, +salt-water fish: 83.9 +/- 47.6 micrograms I/g creatinine; p < 0.05), however, thyroid volume was identical in these groups. The area of residence over the last 10 years did not significantly influence the thyroid volume. The goiter incidence increased with age. Although our study population was highly educated (81.8% students) and the subjects were provided with educational brochures immediately prior to the study, knowledge about iodine content of food was poor. We conclude that despite a high degree of voluntary iodine prophylaxis and educational programs the iodine intake is insufficient. The use of iodized salt in households, cafeterias, and also in food manufacturing must be increased for sufficient iodine prophylaxis.

Adult↗

PubMed1995

Iodine concentration in canteen meals prepared with or without iodized salt.

In each of two university canteens differing in the use (canteen A) or non-use (canteen B) of iodized salt for food preparation, 15 mostly equal lunch meals were collected for iodide and NaCl analysis. With similar NaCl content, the meals of canteen A contained on average 6.1 micrograms I/100 g ww (8.5 micrograms I/g NaCl) more I than the meals of canteen B. Total I intake by consumption of an average meal of canteen A was estimated as 56.5 +/- 24.1 micrograms (canteen B: 17.0 +/- 9.9 micrograms). Consequently, the use of iodized salt in central catering seems to play a more important role in a sufficient I intake than assumed so far.

Cooking↗

PubMed1994

[Nutrient intake in permanent night shift workers].

By means of a modified weight record technique, total dietary intake was obtained in 24 permanent night-shift workers during a period of 7 consecutive days; intake data were attached to eight defined meals. As a control, 25 shift workers of the same company were investigated during the morning shift. Mean daily energy intake was 2866 +/- 616 kcal (12.0 +/- 2.6 MJ) including 14% protein, 39.5% fat, 37.8% carbohydrates, and 8.7% alcohol. Statistically significant differences between groups were found for vitamin E and polyunsaturated fatty acids. In both groups intake data for vitamin A, D, zinc and dietary fiber did not meet 3/4 of the recommendations of the German Nutrition Society. In contrast to controls, nutrient intake of the permanent night-shift workers was slightly less during weekend days; mean meal frequency decreased from 5.4 (weekday) to 4.3. The distribution of total daily nutrient intake to different meals partly did not agree with existing recommendations; however, the deviation seems reasonable. Regarding the risks for accidents as well as the working capacity, the relatively high alcohol intake during working hours has to be criticized.

Adult↗

PubMed1993

Dietary habits and serum lipids of a group of German amateur body-builders.

Dietary intake, nutrient supplementation, and serum lipids were investigated in 13 German male amateur body-builders during a non-competitive period. Dietary information was collected with weighted food records during 14 consecutive days. Daily energy intake was 17.1 +/- 3 MJ including 22 +/- 5% protein, 26 +/- 6% fat, and 49 +/- 4% carbohydrates. "Breads and cereals" and "milk and dairy products" revealed to be the most important food groups. Protein supplements contributed 13% of total protein intake. With food alone the average supply of the vitamins A, D, E and B1 was < 3/4 of the recommended amounts (DGE). Due to the high consumption of supplement preparations, total daily intake of most of the selected minerals and vitamins--particularly of vitamins of the B-group--increased far above recommended dietary intake. Mean fasting serum triglyceride, phospholipid and total cholesterol concentrations were in a normal range, while high-density lipoprotein cholesterol levels were reduced. The serum cholesterol ester fatty acids analysis confirmed a rather low intake of essential fatty acids (linoleic acid) found by dietary assessment. In conclusion, with a few corrections in food selection patterns of the body-builders, a well balanced diet would be achieved and the use of nutrient supplementation products would become totally superfluous.

Adult↗

PubMed1993

Odd-numbered medium-chain triglycerides (trinonanoin) in total parenteral nutrition: parameters of carbohydrate and protein metabolism.

To investigate the metabolic effects of intravenously administered odd-numbered medium-chain triglycerides in healthy non-stressed animals, trinonanoin/long-chain triglyceride (LCT) (7/3) fat emulsions were given in a high dose (46.5% energy) to rabbits (n = 8) for 11 days within a total parenteral nutrition regimen. In comparison with medium-chain triglyceride (MCT)/LCT fat emulsions, higher plasma glucose (day 4), plasma lactate and pyruvate (day 11) and liver glycogen concentrations were found for the test group, indicating a glucogenic effect of the trinonanoin/LCT emulsion. With the present study design, nitrogen balance of the rabbits was not significantly influenced by the kind of fat emulsion administered.

Animals↗

PubMed1993

Organ changes after intravenous trinonanoin administration in rabbits.

For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

Adipose Tissue↗

PubMedDate not supplied

Odd-numbered medium-chain triglycerides (trinonanoin) in total parenteral nutrition: effects on parameters of fat metabolism in rabbits.

Odd-numbered medium-chain triglycerides (MCTs) might combine the advantages of "usual" MCTs applied in clinical nutrition with lower ketogenic action and the release of three carbon units. To test subacute toxicity, trinonanoin/long-chain triglyceride (LCT) (7/3 wt/wt) fat emulsions were given to rabbits (n = 8) for 11 days (7 h/d) within a total parenteral nutrition regimen at a dose of 46.5% of total daily energy. Comparisons were made with rabbits receiving equicaloric amounts of MCT/LCT (7/3, wt/wt) or pure LCT fat emulsions, as well as with orally fed controls. The trinonanoin/LCT emulsion was well tolerated by all animals. Body weight changes showed no statistically significant differences between groups. The enzymatic determination of triglycerides, non-esterified fatty acids, and free glycerol concentrations in plasma samples revealed similar results for both MCT groups. However, ketone body concentrations (3-hydroxybutyrate) were significantly lower after trinonanoin/LCT emulsion administration. In the trinonanoin/LCT group, the plasma concentrations of propionic acid as well as of other short-chain fatty acids continuously increased; on days 10 and 11, elevated amounts of propionic acid were also detected in the urine. The histologic examination of the gut mucosa revealed no distinct differences between groups. On the basis of the presented data, the trinonanoin/LCT emulsion showed no inferiority to "usual" MCT/LCT emulsions. The lower ketogenic effect as well as the marked increase in plasma short-chain fatty acid concentrations may encourage further testing of this substrate for total parenteral nutrition.

3-Hydroxybutyric Acid↗

PubMedDate not supplied

Efficacy of different triglycerides in total parenteral nutrition for preventing atrophy of the gut in traumatized rats.

BACKGROUND: The efficacy of different fat emulsions as components of a total parenteral nutrition (TPN) regimen on the integrity of the gut was assessed in traumatized rats. With the release of the short-chain fatty acids butyric or propionic acid during the hydrolysis of a structured triglyceride containing butyric acid (C4-L-C4-TG) or the beta-oxidation of nonanoic acid from trinonanoin (C9TG), respectively, the infusion of these two triglycerides was supposed to reveal positive effects against the TPN-induced atrophy of the intestine. METHODS: After 3 days of fiber-free liquid diet, rats were traumatized (laparotomy) and catheterized. Afterwards they received equicaloric TPN that delivered 1008 kJ (241 kcal)/kg of body weight per day and 30% nonprotein calories as fat emulsion. The four fat emulsions tested in four groups of six animals contained either long-chain triglycerides (LCT), medium-chain triglycerides (MCT)-LCT (1:1), C9TG/LCT (1:1) or C4-L-C4-TG. Animals of a control group were infused with isovolemic 0.9% NaCl solution and were offered oral standard chow. RESULTS: After 7 days of MCT/LCT administration, the mass-to-length ratio of the total small bowel as well as the masses of mucosa/submucosa and muscularis/serosa in 10-cm segments of the distal half of the small bowel were significantly higher than that found in the other TPN groups or not different from controls. Histometric measurement of the villus height in the ileum revealed no statistically significant differences from controls for the rats of the MCT/LCT and C4-L-C4-TG groups. In the colon, no statistically significant differences between TPN groups were found for either parameter. CONCLUSIONS: Within the tested fatty substrates the MCT/LCT fat emulsion revealed less structural impairments in the distal half of the small bowel regarding mucosa/submucosa (mass and villus height), but also muscularis/ serosa (mass).

Animals↗