Search PubMed⌕ Search

Biomedical subjects

J Link

Publications and source records attributed to J Link.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Buprenorphine and pentazocine for postoperative analgesia. A double blind study following abdominal surgery].

A randomized double-blind study was done to test the two opiates buprenorphine (0.3 mg i.v.) and pentazocine (30 mg i.v.) with regard to their applicability for the postoperative phase. These substances were chosen because they are not subject to drug prescription regulations. 60 patients who had undergone epigastric and hypogastric interventions under thiopental-sodium-induced halothane anesthesia received i.v. injections of one of the two analgetics as soon as they requested a pain-killer postoperatively. The subjective pain intensity registered by means of a visual analogue scale shows a gradual decrease after buprenorphine with maximal effects 1-3 h post injectionem (7.3 leads to 1.5). The duration of action is 8.2 +/- 0.7 h on the average (median 8 h; range 4-22 h). The maximal analgetic effect of pentazocine is already attained after 10 min (6.3 leads to 3.2). Thereafter the pain-intensity curve rises again. Pentazocine has a mean duration of action of 2.35 +/- 0.24 h (median 2 h; range 0.5-5 h). The inadequate analgetic effect of pentazocine manifests itself in an only slight initial reduction of the respiratory rate (19.5 leads to 17.5 min-1), which, on the other hand, decreases significantly and continuously under buprenorphine (20.8 leads to 13.5 min-1). Both substances cause increases of PaCO2 (buprenorphine 37.3 leads to 46.8 mmHg; pentazocine 36.3 leads to 43.0 mmHg), values greater than 50 mmHg being attained in individual cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Abdomen↗
PubMed1982

Binding of nickel (II) to 5'-nucleoside monophosphates and related compounds.

The interactions of Ni(II) cation with a representative suite of purine bases and the respective nucleosides and nucleotides have been studied by ultraviolet difference spectroscopy. Apparent association constants, Kapp, were determined for each system at pH 7.0, using computer linear regression coupled with an iteration technique. The specificity of binding of Ni2+ for the purine nucleotides studied at pH 7.0 was 5'-GMP greater than 5'-IMP greater than 5'-AMP; a similar ordering was also found for the respective nucleosides and bases. In this study binding was not observed for the suite of pyramidines used, although a Ni2+ - cytidine complex has been observed (Fiskin and Beer, 1965). It was also found that Ni2+ bound more strongly to the purine 5'-nucleotides than to the respective nucleosides and bases. These trends are explained in terms of metal-ligand bonds and available bonding positions on the ligands. A role for metal-ion-nucleotide types of complexes is suggested in the processes that might have given rise to the origin of life.

Adenine↗
PubMed1982

Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy.

Neural control of renin secretion is an important physiologic mechanism, but alterations in the central nervous system feedback and control of renin release in heart failure have not been investigated. Accordingly we studied conscious dogs after volume overload (arteriovenous fistula) or chronic myocardial infarction. Acute infusion of nitroprusside was used to test the renin response to arterial hypotension and decreased central blood volume. Hydralazine and prazosin administration were used to test the response to chronic vasodilator administration. After 4 weeks of volume overload or 3 weeks after myocardial infarction, the renin response to a graded hypotensive stimulus was blunted. After 7 days of hydralazine or prazosin administration, plasma renin activity remained elevated and blood volume increased from baseline values. Our results indicate a decrease in the neural feedback control of renin release after chronic volume overload or myocardial infarction. However, chronic vasodilator administration still resulted in sustained augmented renin secretion and an increase in blood volume.

Animals↗
PubMed1981

[Servo-ventilator 900 B with modified registration site for measuring the ventilation pressure. A possibility for reducing the inspiratory resistance during SIMV (author's transl)].

The inspiratory resistance, which a patient has to overcome while doing SIMV and CPAP with a Servoventilator 900 B, can be lowered by a simple modification of the ventilator. This modification is done by measuring the ventilation-pressure at the patients side of the humidifier. Measurements of pressure and flow demonstrated that, with a flow of 11 s-1 a 66%-reduction of the inspiratory resistance can be achieved.

Airway Resistance↗
PubMed1980

[Electronic data processing in anaesthesia. Development of a data collection form and organisation of data collection (author's transl)].

We report on the development of a data collection form for anaesthesia. The difference between this form and the previously published recommendations is that it does not require any coding of data prior to collection. The anaesthetist completing the form needs no knowledge of data processing. Qualitative data have only to be marked, while quantitative data must be entered as such. So far, more than 90,000 anaesthesias have been collected with the form presented, therefore usefulness may be assumed.

Anesthesiology↗
PubMed1978

Melanoma in a patient treated for psoriasis.

Psoriasis, ultraviolet light, and coal tar have been associated with the development of cutaneous malignancy. We have described a 32-year-old psoriatic man who developed a melanoma after 16 years of treatment with ultraviolet light and coal tar. This is the only case of melanoma occurring in a patient treated for psoriasis reported in the world literature.

Adult↗
PubMed1978

[Nitrous oxide in the working environment of anaesthetic personnel. A gas chromatographic analysis (author's transl)].

Nitrous oxide as well as halothane is hazardous for organ dysfunction in chronically exposed man. It is necessary for each anaesthetist, in cooperation with the hospital authorities, to take care to eliminate overflow not only of halothane but also of nitrous oxide from anaesthetia locations. Using gas chromatography, we studied the concentration of nitrous oxide during routine daily work in the environment of anaesthetic personnel. With our method of discharging anaesthetic gases, we were able to reduce the concentration of nitrous oxide.

Air Pollutants↗
PubMed1976

[Control of respirator pressure and drainage of the anesthetic gases with Kuhn's device in pediatric anesthesia (author's transl)].

By adding a manometer and a pressure valve to the anaesthetic equipment used for newborns and children (Ayre-T-piece, modified by Kuhn) we are able to control airway pressures continuously and to draw out all narcotic gases from the operating room. The concentration of halothanee thus can be diminished to a very low level around the aneasthesist and the surgeon.

Air Pollution↗
PubMed1976

[The concentrations of halothane in the operating theatre and its dependance on various methods of removal (author's transl)].

Measurement of halothane concentrations by means of gas chromatography was used to compare the efficiency of 1) a filtration system and 2) ducting of gases into the exhaust of the ventilation system of our operating threatre. The concentrations were found to be lower when the latter method was used. Measurements made subsequently provided data on halothane concentrations occurring during routine service when different methods of anaesthesia were used, with and without ducting of gases into the ventilation exhaust system.

Air↗
PubMed1975

[Intranarcotic infusion therapy -- a computer interpretation using the program package SPSS (Statistical Package for the Social Sciences)].

In a retrospective 18-month study the infusion therapy applied in a great anesthesia institute is examined. The data of the course of anesthesia recorded on magnetic tape by routine are analysed for this purpose bya computer with the statistical program SPSS. It could be proved that the behaviour of the several anesthetists is very different. Various correlations are discussed.

Adolescent↗