Dose-response relationships were established for yield of dicentrics and for a fraction of damaged metaphases in lymphocytes after gamma-irradiation of rabbits' whole blood in vitro. These relationships were based on the scoring of cells only in their first post-stimulation division and they served as a reference system for comparison with results of 60Co gamma-irradiation in vivo, either of the whole or of predetermined parts of an animal's body. There was a statistically acceptable agreement between dose-response data established for dicentric yield after whole-body irradiation in vivo and the reference dose-response curve derived from exposure of rabbit's blood in vitro. For partial-body (1/2) irradiations there was a satisfactory agreement between the dose-response curves in vitro for dicentric yield and fraction of metaphases damaged on the one hand and the response in vivo when the latter was related to mean doses to circulating blood. However, there was a drastic disagreement with the dose responses in vitro when measured cytogenetic quantities were plotted versus mean doses to body mass. When the latter were substituted for by comparable doses to circulating blood the in vivo-in vitro agreement was acceptable after irradiation of 'cerebral' 1/2 mass and very much improved for the 'caudal' 1/2 exposures. Therefore, it is concluded that, after partial-body irradiations, the dicentric yield or fraction of damaged metaphases in lymphocytes sampled immediately after exposure reflect mean dose to circulating blood irrespective of whether or not this dose coincides with mean dose to body mass.

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Dose-response relationships for chromosome aberrations in peripheral blood lymphocytes after whole- and partial-body irradiations. II. Decline of aberration-carrying cells in blood with time post-exposure.

Dicentric yield and fractionation of damaged metaphases and lymphocyte count were followed for an interval of up to 3 months in rabbits after partial- and whole-body irradiations. Some partial-body exposures led to less-pronounced decline of the lymphocyte count in peripheral blood than others; in the former case the reduction of dicentric yield in peripheral blood lymphocytes over the first 24 h post exposure was significantly faster than in the latter. The decline was also faster than after uniform whole-body irradiation where it was virtually absent. However, the results suggest that, after whole-body exposures, the decline of the fraction of damaged metaphases with post-exposure time was much slower than that of the dicentric yield.

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[Occupational exposure to x-irradiation in Poland. Probability of exceeding the vital dosage].

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The influence of sodium diethyldithiocarbamate (DDC) on serum lipids in the rabbit.

The influence of sodium diethyldithiocarbamate (DDC) on serum lipids in the rabbit. Acta Physiol. Pol., 1979, 30 (2): 327--329. The level of cholesterol, phospholipids and triglycerides in blood serum of rabbits treated with sodium diethyldithiocarbamate (DDC) was determined. DDC administration in daily doses of 100, 200 and 400 mg/kg, during 4 weeks, resulted in an increase of triglyceride and phospholipid levels changes were found in the serum cholesterol concentration.

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