[Clinical evaluation of pyridinolcarbamate effect on patients with obliterating atherosclerosis (author's transl)].
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Biomedical subjects
Publications and source records attributed to J Linhart.
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The effect of the anabolic hormone 19-nortestosterone propionate (Superanabolon Spofa) on the metabolism of chronically ischaemic striated muscle (anterior tibial m.) was studied in a described model in the rat. Metabolic changes were estimated in terms of the activities of a number of enzymes in muscle fibres. Enzyme activities (AcP, ATPase, CE, LDH, MDH) were determined both biochemically and histochemically excepting SDH, which was determined only by the histochemical way. Morphological changes were investigated by routine histology. Administration of 19-nortestosterone propionate prevented enzymatic changes which are typical for chronic ischaemia, primarily the decrease in the activities of dehydrogenases of Krebs' cycle tricarboxylic acides (MDH, SDH). In addition, the ratio of red to white muscle fibres increased. Administration of anabolic hormone has a similar favourable action on ischaemic muscle as training, studied previously.
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In 11 patients with occlusive arterial disease and severe cutaneous ischaemia, orthostasis procuded a significant decrease in the I-131 clearance in the distal crural subcutis. In the metatarsal subcutis, however, the mean clearance value remained unchanged on the average, and in patients with low initial clearance values it mostly increased.
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At isometric contraction of forearm muscles, the mean systemic pressure and the foot blood flow are statistically significantly increased. These changes are encountered both in controls and in patients with an ischaemic disease of the lower extremities.
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